免疫细胞互噬作用在移植免疫中的研究进展

赵阳; 周林; 贺强

doi:10.3969/j.issn.1674-7445.2021.01.017

免疫细胞互噬作用在移植免疫中的研究进展

doi: 10.3969/j.issn.1674-7445.2021.01.017

100020 首都医科大学附属北京朝阳医院肝胆胰脾外科

基金项目:

国家自然科学基金 81571825

详细信息

作者简介:
赵阳，男，1993年生，博士研究生，研究方向为肝移植的基础与临床研究，Email：zhaoyang235792@163.com

通讯作者:
贺强，男，1964年生，博士，主任医师，研究方向为肝移植与肝胆胰恶性肿瘤，Email：heqiang349@sina.com

中图分类号: R617, R392.4
计量
- 文章访问数: 244
- HTML全文浏览量: 122
- PDF下载量: 45
- 被引次数: 0
出版历程
- 收稿日期: 2020-08-25
- 网络出版日期: 2021-01-19
- 刊出日期: 2021-01-19

Research progress on trogocytosis of immune cell in transplantation immunity

Department of Hepatobiliary, Pancreatic and Splenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

More Information

Corresponding author: He Qiang, E-mail:heqiang349@sina.com

摘要

摘要: 互噬作用是指细胞通过直接接触发生的部分细胞膜片段或细胞浆内容交换的过程，是存在于细胞间的一种相互作用机制。免疫细胞可通过互噬作用获得对方细胞的部分特性，通过互噬作用产生的新细胞在移植免疫耐受的诱导中可能起到重要作用。本文就细胞互噬作用研究的起源和发展、细胞互噬作用的机制及免疫细胞互噬作用的生物学意义进行综述。
- 互噬作用 /
- 免疫细胞 /
- 免疫调节 /
- 吞噬作用 /
- 抗原提呈 /
- 移植免疫 /
- 肿瘤免疫 /
- 细胞杀伤
Abstract: Trogocytosis is a process of exchanging part of the membrane fragment or cytoplasmic content of cells through direct contact, and it's an interaction mechanism that exists between cells. Immune cell can obtain some characteristics of other cells through trogocytosis, and the new cells generated through trogocytosis may play an important role in the induction of graft immune tolerance. In this article, the origin and development of research on cell trogocytosis, mechanism of cell trogocytosis and biological significance of trogocytosis of immune cell were reviewed.
- Trogocytosis /
- Immune cell /
- Immune regulation /
- Phagocytosis /
- Antigen presentation /
- Transplantation immunity /
- Tumor immunity /
- Cell killer

HTML全文

参考文献(44)

[1]	BROWN T. Observations by immunofluorescence microscopy and electron microscopy on the cytopathogenicity of Naegleria fowleri in mouse embryo-cell cultures[J]. J Med Microbiol, 1979, 12(3):363-371. DOI: 10.1099/00222615-12-3-363.
[2]	NAKAYAMA M. Antigen presentation by MHC-dressed cells[J]. Front Immunol, 2015, 5:672. DOI: 10.3389/fimmu.2014.00672.
[3]	WADDELL DR, VOGEL G. Phagocytic behavior of the predatory slime mold, dictyostelium caveatum. cell nibbling[J]. Exp Cell Res, 1985, 159(2):323-334. DOI: 10.1016/s0014-4827(85)80006-9.
[4]	CONE RE, SPRENT J, MARCHALONIS JJ. Antigen-binding specificity of isolated cell-surface immunoglobulin from thymus cells activated to histocompatibility antigens[J]. Proc Natl Acad Sci U S A, 1972, 69(9):2556-2560. DOI: 10.1073/pnas.69.9.2556.
[5]	CAMPANA S, DE PASQUALE C, CARREGA P, et al. Cross-dressing: an alternative mechanism for antigen presentation[J]. Immunol Lett, 2015, 168(2):349-354. DOI: 10.1016/j.imlet.2015.11.002.
[6]	SOMANCHI A, LEE DA, SOMANCHI SS. Engineering receptor expression on natural killer cells through trogocytosis[J]. Methods Mol Biol, 2016, 1441:253-265. DOI: 10.1007/978-1-4939-3684-7_21.
[7]	GARDELL JL, PARKER DC. CD40L is transferred to antigen-presenting B cells during delivery of T-cell help[J]. Eur J Immunol, 2017, 47(1):41-50. DOI: 10.1002/eji.201646504.
[8]	DUSTIN ML. Help to go: T cells transfer CD40L to antigen-presenting B cells[J]. Eur J Immunol, 2017, 47(1):31-34. DOI: 10.1002/eji.201646786.
[9]	DANCE A. Core concept: cells nibble one another via the under-appreciated process of trogocytosis[J]. Proc Natl Acad Sci U S A, 2019, 116(36):17608-17610. DOI: 10.1073/pnas.1912252116.
[10]	JOLY E, HUDRISIER D. What is trogocytosis and what is its purpose?[J]. Nat Immunol, 2003, 4(9):815. DOI: 10.1038/ni0903-815.
[11]	YEWDELL JW, HAERYFAR SM. Understanding presentation of viral antigens to CD8⁺ T cells in vivo: the key to rational vaccine design[J]. Annu Rev Immunol, 2005, 23:651-682. DOI:10.1146/annurev.immunol.23. 021704.115702.
[12]	ZENG F, MORELLI AE. Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer[J]. Semin Immunopathol, 2018, 40(5):477-490. DOI: 10.1007/s00281-018-0679-8.
[13]	SHAO Z, HARFUDDIN Z, PANG WL, et al. Trogocytic CD137 transfer causes an internalization of CD137 ligand on murine APCs leading to reduced T cell costimulation[J]. J Leukoc Biol, 2015, 97(5):909-919. DOI: 10.1189/jlb.3A0213-079RRR.
[14]	BARINOV A, GALGANO A, KRENN G, et al. CD4/CD8/dendritic cell complexes in the spleen: CD8⁺ T cells can directly bind CD4⁺ T cells and modulate their response[J]. PLoS One, 2017, 12(7):e0180644. DOI: 10.1371/journal.pone.0180644.
[15]	WEINHARD L, DI BARTOLOMEI G, BOLASCO G, et al. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction[J]. Nat Commun, 2018, 9(1):1228. DOI: 10.1038/s41467-018-03566-5.
[16]	ABDU Y, MANISCALCO C, HEDDLESTON JM, et al. Developmentally programmed germ cell remodelling by endodermal cell cannibalism[J]. Nat Cell Biol, 2016, 18(12):1302-1310. DOI: 10.1038/ncb3439.
[17]	STEELE S, RADLINSKI L, TAFT-BENZ S, et al. Trogocytosis-associated cell to cell spread of intracellular bacterial pathogens[J]. Elife, 2016, 5:e10625. DOI: 10.7554/eLife.10625.
[18]	MILLER HW, SULEIMAN RL, RALSTON KS. Trogocytosis by entamoeba histolytica mediates acquisition and display of human cell membrane proteins and evasion of lysis by human serum[J]. mBio, 2019, 10(2):e00068-19. DOI: 10.1128/mBio.00068-19.
[19]	REED J, WETZEL SA. Trogocytosis-mediated intracellular signaling in CD4⁺ T cells drives Th2-associated effector cytokine production and differentiation[J]. J Immunol, 2019, 202(10):2873-2887. DOI: 10.4049/jimmunol.1801577.
[20]	赵国宪, 贺强, 韩东冬, 等.免疫细胞的互噬作用在器官移植免疫耐受中的研究进展[J].中华器官移植杂志, 2015, 36(1):55-58. DOI:10.3760/cma.j.issn.0254-1785. 2015.01.015. ZHAO GX, HE Q, HAN DD, et al. Research progress on trogocytosis in immune tolerance of organ transplantation[J]. Chin J Organ Transplant, 2015, 36(1):55-58. DOI: 10.3760/cma.j.issn.0254-1785.2015.01.015.
[21]	RALSTON KS. Taking a bite: amoebic trogocytosis in entamoeba histolytica and beyond[J]. Curr Opin Microbiol, 2015, 28:26-35. DOI: 10.1016/j.mib.2015.07.009.
[22]	OSBORNE DG, WETZEL SA. Trogocytosis results in sustained intracellular signaling in CD4(+) T cells[J]. J Immunol, 2012, 189(10):4728-4739. DOI: 10.4049/jimmunol.1201507.
[23]	BETTADAPUR A, MILLER HW, RALSTON KS. Biting off what can be chewed: trogocytosis in health, infection, and disease[J]. Infect Immun, 2020, 88(7):e00930-19. DOI: 10.1128/IAI.00930-19.
[24]	MARTÍNEZ-MARTÍN N, FERNÁNDEZ-ARENAS E, CEMERSKI S, et al. T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis[J]. Immunity, 2011, 35(2):208-222. DOI: 10.1016/j.immuni.2011.06.003.
[25]	MIYAKE K, SHIOZAWA N, NAGAO T, et al. Trogocytosis of peptide-MHC class Ⅱ complexes from dendritic cells confers antigen-presenting ability on basophils[J]. Proc Natl Acad Sci U S A, 2017, 114(5):1111-1116. DOI: 10.1073/pnas.1615973114.
[26]	FREEMAN SA, GRINSTEIN S. Phagocytosis: mechanosensing, traction forces, and a molecular clutch[J]. Curr Biol, 2020, 30(1):R24-R26. DOI: 10.1016/j.cub.2019.11.047.
[27]	LEMKE G. How macrophages deal with death[J]. Nat Rev Immunol, 2019, 19(9):539-549. DOI: 10.1038/s41577-019-0167-y.
[28]	SOMLATA, NAKADA-TSUKUI K, NOZAKI T. AGC family kinase 1 participates in trogocytosis but not in phagocytosis in entamoeba histolytica[J]. Nat Commun, 2017, 8(1):101. DOI: 10.1038/s41467-017-00199-y.
[29]	MERCER F, NG SH, BROWN TM, et al. Neutrophils kill the parasite trichomonas vaginalis using trogocytosis[J]. PLoS Biol, 2018, 16(2):e2003885. DOI: 10.1371/journal.pbio.2003885.
[30]	GONG J, GAITANOS TN, LUU O, et al. Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development[J]. J Cell Biol, 2019, 218(10):3455-3471. DOI: 10.1083/jcb.201901032.
[31]	MATLUNG HL, BABES L, ZHAO XW, et al. Neutrophils kill antibody-opsonized cancer cells by trogoptosis[J]. Cell Rep, 2018, 23(13):3946-3959. DOI: 10.1016/j.celrep.2018.05.082.
[32]	AMIOT L, VU N, SAMSON M. Biology of the immunomodulatory molecule HLA-G in human liver diseases[J]. J Hepatol, 2015, 62(6):1430-1437. DOI: 10.1016/j.jhep.2015.03.007.
[33]	TIAN D, YANG L, WANG S, et al. Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma[J]. Nat Commun, 2019, 10(1):4246. DOI: 10.1038/s41467-019-12243-0.
[34]	YAMANISHI Y, MIYAKE K, IKI M, et al. Recent advances in understanding basophil-mediated Th2 immune responses[J]. Immunol Rev, 2017, 278(1):237-245. DOI: 10.1111/imr.12548.
[35]	GÜL N, VAN EGMOND M. Antibody-dependent phagocytosis of tumor cells by macrophages: a potent effector mechanism of monoclonal antibody therapy of cancer[J]. Cancer Res, 2015, 75(23):5008-5013. DOI: 10.1158/0008-5472.CAN-15-1330.
[36]	VELMURUGAN R, CHALLA DK, RAM S, et al. Macrophage-mediated trogocytosis leads to death of antibody-opsonized tumor cells[J]. Mol Cancer Ther, 2016, 15(8):1879-1889. DOI: 10.1158/1535-7163.MCT-15-0335.
[37]	TAYLOR RP, LINDORFER MA. Analyses of CD20 monoclonal antibody-mediated tumor cell killing mechanisms: rational design of dosing strategies[J]. Mol Pharmacol, 2014, 86(5):485-491. DOI: 10.1124/mol.114.092684.
[38]	MINER CA, GIRI TK, MEYER CE, et al. Acquisition of activation receptor ligand by trogocytosis renders NK cells hyporesponsive[J]. J Immunol, 2015, 194(4):1945-1953. DOI: 10.4049/jimmunol.1402408.
[39]	LIN A, YAN WH. Intercellular transfer of HLA-G: its potential in cancer immunology[J]. Clin Transl Immunology, 2019, 8(9):e1077. DOI: 10.1002/cti2.1077.
[40]	SMYTH LA, LECHLER RI, LOMBARDI G. Continuous acquisition of MHC:peptide complexes by recipient cells contributes to the generation of anti-graft CD8⁺ T cell immunity[J]. Am J Transplant, 2017, 17(1):60-68. DOI: 10.1111/ajt.13996.
[41]	LIU Q, ROJAS-CANALES DM, DIVITO SJ, et al. Donor dendritic cell-derived exosomes promote allograft-targeting immune response[J]. J Clin Invest, 2016, 126(8):2805-2820. DOI: 10.1172/JCI84577.
[42]	ONO Y, PEREZ-GUTIERREZ A, NAKAO T, et al. Graft-infiltrating PD-L1^hi cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance[J]. Hepatology, 2018, 67(4):1499-1515. DOI: 10.1002/hep.29529.
[43]	HUGHES AD, ZHAO D, DAI H, et al. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts[J]. J Clin Invest, 2020, 130(1):287-294. DOI: 10.1172/JCI125773.
[44]	MILLS EA, DAVIS CH, BUSHONG EA, et al. Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of xenopus laevis at metamorphosis[J]. Proc Natl Acad Sci U S A, 2015, 112(33):10509-10514. DOI: 10.1073/pnas.1506486112.