边缘供肝面临的机遇与挑战

鲁欣翼; 滕飞; 傅宏; 赵渊宇; 朱鲤烨; 董家勇; 毛家玺; 郭闻渊

doi:10.3969/j.issn.1674-7445.2024002

边缘供肝面临的机遇与挑战

doi: 10.3969/j.issn.1674-7445.2024002

1.
200003　上海，海军军医大学第二附属医院（上海长征医院）器官移植科
2.
海军军医大学免疫学教研室暨医学免疫学国家重点实验室

基金项目: 国家自然科学基金面上项目（82371792、81971503）；医学免疫学国家重点实验室开放课题项目（NKLMI2023K03）；海军军医大学校级基础医学研究课题项目（2022QN072）

详细信息

作者简介:

通讯作者:
郭闻渊（ORCID 0000-0003-3313-3881），医学博士，主任医师，研究方向为肝移植及复杂肝脏外科手术学，Email：guowenyuan@smmu.edu.cn；毛家玺（ORCID 0000-0001-5006-6153），医学硕士，主治医师，研究方向为肝移植围手术期管理，Email：guowenyuan@smmu.edu.cn

中图分类号: R617,R575
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- 被引次数: 0
出版历程
- 收稿日期: 2024-01-02
- 网络出版日期: 2024-02-29

Opportunities and challenges of marginal donor liver

1.
Department of Organ Transplantation, the Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital), Shanghai 200003, China

More Information

Corresponding author: Guo Wenyuan, Email: guowenyuan@smmu.edu.cn Mao Jiaxi, Email: guowenyuan@smmu.edu.cn

摘要

摘要: 随着手术技术和术后免疫抑制治疗的不断突破与成熟，肝移植受者和移植物存活率显著提高，供肝短缺已成为限制肝移植临床发展的主要阻碍，如何扩大供肝来源也成为了当前迫切需要解决的问题。高龄供肝、脂肪变性供肝、病毒性肝炎供肝、心脏死亡器官捐献供肝等常见边缘供肝在临床肝移植中的使用已经取得了一定的突破性进展，但边缘供肝的使用仍存在较多限制。因此，本文对边缘供肝的定义，几种常见边缘供肝的应用及研究进展进行综述，探讨目前扩大肝移植供者池面临的机遇与挑战，旨在为临床肝移植供体池的扩大提供参考，造福更多终末期肝病患者。
- 肝移植 /
- 边缘供肝 /
- 高龄 /
- 脂肪变性 /
- 病毒性肝炎 /
- 劈离式肝移植 /
- 心脏死亡器官捐献 /
- 机械灌注
Abstract: With persistent breakthrough and maturity of surgical procedures and postoperative immunosuppressive therapy, the survival rate of liver transplant recipients and grafts has been significantly increased. The shortage of donor liver has become the main obstacle for clinical development of liver transplantation. How to expand the source of donor liver has become an urgent issue. Groundbreaking progresses have been made in the use of common marginal donor livers in clinical liver transplantation, such as elderly donor liver, steatosis donor liver, viral hepatitis donor liver and liver from donation after cardiac death. Nevertheless, multiple restrictions still exist regarding the use of marginal donor liver. Consequently, the definition of marginal donor liver and research progress in the application of common marginal donor livers were reviewed, and the opportunities and challenges for expanding the existing donor pool for liver transplantation were illustrated, aiming to provide reference for expanding the donor pool for clinical liver transplantation and bringing benefits to more patients with end-stage liver disease.
- Liver transplantation /
- Marginal donor liver /
- Elderly /
- Steatosis /
- Viral hepatitis /
- Split liver transplantation /
- Donation after cardiac death /
- Machine perfusion

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参考文献(52)

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