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巨噬细胞在移植肾纤维化中的作用研究进展

任滌非, 王於尘, 苗芸. 巨噬细胞在移植肾纤维化中的作用研究进展[J]. 器官移植, 2023, 14(5): 723-729. doi: 10.3969/j.issn.1674-7445.2023084
引用本文: 任滌非, 王於尘, 苗芸. 巨噬细胞在移植肾纤维化中的作用研究进展[J]. 器官移植, 2023, 14(5): 723-729. doi: 10.3969/j.issn.1674-7445.2023084
Ren Difei, Wang Yuchen, Miao Yun. Research progress on the role of macrophages in renal allograft fibrosis[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 723-729. doi: 10.3969/j.issn.1674-7445.2023084
Citation: Ren Difei, Wang Yuchen, Miao Yun. Research progress on the role of macrophages in renal allograft fibrosis[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 723-729. doi: 10.3969/j.issn.1674-7445.2023084

巨噬细胞在移植肾纤维化中的作用研究进展

doi: 10.3969/j.issn.1674-7445.2023084
基金项目: 国家自然科学基金(82270784、82070770、82170767);广东省基础与应用基础研究基金(2023A1515012276);大学生创新创业训练计划项目(202212121242)
详细信息
    作者简介:
    通讯作者:

    苗芸(ORCID:0000-0003-3592-4695),博士,主任医师,研究方向为肾移植,Email:miaoyunecho@126.com

  • 中图分类号: R617, R329.2

Research progress on the role of macrophages in renal allograft fibrosis

More Information
  • 摘要: 缺血-再灌注损伤、排斥反应、钙调磷酸酶抑制剂造成的肾毒性等因素会在肾移植术后使肾细胞外基质过度积聚,逐渐造成移植肾纤维化,最终导致肾衰竭。近年来,巨噬细胞在移植肾纤维化中的作用机制逐渐受到关注,有研究表明哺乳动物雷帕霉素靶蛋白抑制剂等药物可以通过巨噬细胞途径减缓肾移植术后移植肾纤维化。本文就移植肾纤维化的主要病因及病理生理学机制、不同巨噬细胞在移植肾纤维化进展中的作用、外周募集巨噬细胞和肾驻留巨噬细胞对肾损伤区域的浸润、巨噬细胞对肌成纤维细胞的诱导作用及巨噬细胞相关的移植肾纤维化潜在治疗方案进行综述,以期为巨噬细胞在移植肾纤维化中的研究提供参考。

     

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出版历程
  • 收稿日期:  2023-04-16
  • 录用日期:  2023-07-07
  • 网络出版日期:  2023-07-20
  • 刊出日期:  2023-09-15

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