Research progress on human leukocyte antigen-G in clinical medicine
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摘要: 人类白细胞抗原(HLA)-G是一类非经典HLAⅠb类分子, 早期的研究主要集中在妊娠免疫, HLA-G可保护胎儿免受母体免疫系统的攻击。近几年越来越多的研究发现HLA-G在诱导器官移植物免疫耐受、协助肿瘤细胞以及病毒的免疫逃逸中发挥着重要作用。因此将HLA-G作为器官移植、恶性肿瘤和病毒感染等疾病诊断和治疗的靶点已逐渐成为学者关注的热点。本文就HLA-G的基因多态性与分子结构、HLA-G在临床医学中应用的最新进展做一总结。
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