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氧化应激反应在边缘供肝肝移植缺血-再灌注损伤中的作用研究进展

高伟东 杨龙龙 尹清臣

高伟东, 杨龙龙, 尹清臣. 氧化应激反应在边缘供肝肝移植缺血-再灌注损伤中的作用研究进展[J]. 器官移植, 2022, 13(1): 126-131. doi: 10.3969/j.issn.1674-7445.2022.01.019
引用本文: 高伟东, 杨龙龙, 尹清臣. 氧化应激反应在边缘供肝肝移植缺血-再灌注损伤中的作用研究进展[J]. 器官移植, 2022, 13(1): 126-131. doi: 10.3969/j.issn.1674-7445.2022.01.019
Gao Weidong, Yang Longlong, Yin Qingchen. Research progress on the role of oxidative stress in ischemia-reperfusion injury of marginal donor liver transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(1): 126-131. doi: 10.3969/j.issn.1674-7445.2022.01.019
Citation: Gao Weidong, Yang Longlong, Yin Qingchen. Research progress on the role of oxidative stress in ischemia-reperfusion injury of marginal donor liver transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(1): 126-131. doi: 10.3969/j.issn.1674-7445.2022.01.019

氧化应激反应在边缘供肝肝移植缺血-再灌注损伤中的作用研究进展

doi: 10.3969/j.issn.1674-7445.2022.01.019
基金项目: 

河北省重点研发计划 182777241

详细信息
    作者简介:

    高伟东,男,1994年生,硕士,住院医师,研究方向为肝脏缺血-再灌注损伤机制及保护,Email:1015798962@qq.com

    通讯作者:

    尹清臣,男,1968年生,硕士,主任医师,研究方向为肝脏相关疾病防治,Email:yqc1909@163.com

  • 中图分类号: R617, R364.5

Research progress on the role of oxidative stress in ischemia-reperfusion injury of marginal donor liver transplantation

More Information
  • 摘要: 常见的边缘供肝主要包括脂肪变性供肝、高龄供肝、小体积供肝、心脏死亡器官捐献(DCD)供肝等。边缘供肝的应用可在一定程度上解决供肝数量严重短缺的问题,但边缘供肝面临着缺血-再灌注损伤(IRI)的难题,且IRI程度相比正常供肝更加严重,是导致移植失败的重要原因,其中氧化应激反应又是引起边缘供肝IRI的重要因素。因此如何减少氧化应激反应及解决边缘供肝IRI的难题成为临床研究的热点问题。活性氧簇(ROS)介导的氧化应激反应贯穿IRI整个过程,本文就氧化应激反应在边缘供肝肝移植IRI中的作用及以ROS为靶点的防治进行综述,以期为临床提供参考。

     

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出版历程
  • 收稿日期:  2021-08-25
  • 网络出版日期:  2022-01-12
  • 刊出日期:  2022-01-15

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