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肾脏常温机械灌注与无缺血肾移植

吴国彬 陈国栋

吴国彬, 陈国栋. 肾脏常温机械灌注与无缺血肾移植[J]. 器官移植, 2022, 13(1): 32-37. doi: 10.3969/j.issn.1674-7445.2022.01.005
引用本文: 吴国彬, 陈国栋. 肾脏常温机械灌注与无缺血肾移植[J]. 器官移植, 2022, 13(1): 32-37. doi: 10.3969/j.issn.1674-7445.2022.01.005
Wu Guobin, Chen Guodong. Normothermic machine perfusion of kidney and ischemia-free kidney transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(1): 32-37. doi: 10.3969/j.issn.1674-7445.2022.01.005
Citation: Wu Guobin, Chen Guodong. Normothermic machine perfusion of kidney and ischemia-free kidney transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(1): 32-37. doi: 10.3969/j.issn.1674-7445.2022.01.005

肾脏常温机械灌注与无缺血肾移植

doi: 10.3969/j.issn.1674-7445.2022.01.005
基金项目: 

国家自然科学基金 81871257

广东省自然科学基金 2018A030313612

中山大学附属第一医院柯麟新星计划项目 Y50176

详细信息
    作者简介:

    吴国彬,男,1997年生,硕士研究生,研究方向为肾移植,Email:wugb7@mail2.sysu.edu.cn

    陈国栋,男,1979年生,博士,现任中山大学附属第一医院器官移植科主任医师,博士研究生导师。兼任广东省泌尿生殖协会肾脏移植学分会副主任委员、广东省医学会器官移植学分会青年委员、美国移植学会会员、欧洲移植学会会员。兼任《器官移植》杂志通讯编委。主要研究方向为无缺血肾移植、ABO血型不相容活体肾移植、预致敏患者肾移植术前脱敏治疗、肾移植术后感染的防治以及移植免疫耐受机制研究。主持国家自然科学基金项目2项、广东省自然科学基金1项,参与其他国家自然基金项目6项,入选首批“广东省杰出青年医学人才”。近年来在国内外核心期刊发表论文60余篇,其中以第一作者和通信作者发表SCI论文18篇,有2篇发表在《American Journal of Transplantation》上。学术成果多次在世界移植大会、美国移植大会、欧洲移植大会和全国器官移植大会等国内外学术会议上进行交流

    通讯作者:

    陈国栋,Email:chenguodong2000@163.com

  • 中图分类号: R617, R699.2

Normothermic machine perfusion of kidney and ischemia-free kidney transplantation

More Information
  • 摘要: 为了增加扩大标准供者(ECD)肾脏的利用率,肾脏保存方法近年来在不断发展。常温机械灌注(NMP)的使用,促进了离体供肾保存、评估和修复,以及肾移植手术方式革新。中山大学附属第一医院器官移植中心首创的无缺血肾移植(IFKT)手术,利用肾脏NMP机器在供肾获取、保存、移植全过程中,保持供肾血流和供氧不中断,从根本上避免了供肾缺血-再灌注损伤(IRI),降低了术后移植物功能延迟恢复(DGF)和急性排斥反应发生的风险。本文着重总结肾脏NMP的新进展,以及IFKT手术方式和近期疗效,旨在为提高ECD供肾利用率、解决器官短缺的问题提供参考。

     

  • 图  1  传统肾移植手术和3种NMP应用方式比较

    Figure  1.  Traditional kidney transplantation and comparison of three NMP application methods

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出版历程
  • 收稿日期:  2021-09-07
  • 网络出版日期:  2022-01-12
  • 刊出日期:  2022-01-15

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