留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

间充质干细胞治疗缺血性胆道损伤的研究进展

代鑫 程龙 王强 骆助林 汪涛

代鑫, 程龙, 王强, 等. 间充质干细胞治疗缺血性胆道损伤的研究进展[J]. 器官移植, 2021, 12(6): 748-753. doi: 10.3969/j.issn.1674-7445.2021.06.016
引用本文: 代鑫, 程龙, 王强, 等. 间充质干细胞治疗缺血性胆道损伤的研究进展[J]. 器官移植, 2021, 12(6): 748-753. doi: 10.3969/j.issn.1674-7445.2021.06.016
Dai Xin, Cheng Long, Wang Qiang, et al. Research progress on mesenchymal stem cell in treatment of ischemic-type biliary lesion[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 748-753. doi: 10.3969/j.issn.1674-7445.2021.06.016
Citation: Dai Xin, Cheng Long, Wang Qiang, et al. Research progress on mesenchymal stem cell in treatment of ischemic-type biliary lesion[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 748-753. doi: 10.3969/j.issn.1674-7445.2021.06.016

间充质干细胞治疗缺血性胆道损伤的研究进展

doi: 10.3969/j.issn.1674-7445.2021.06.016
基金项目: 

四川省青年科技基金项目 2016JQ0023

详细信息
    作者简介:

    代鑫,男,1994年生,硕士研究生,住院医师,研究方向为肝胆疾病基础与临床,Email:daision1994@163.com

    通讯作者:

    汪涛,男,1968年生,主任医师,研究方向为肝胆胰疾病外科微创治疗,Email:watopo@163.com

  • 中图分类号: R617, R392.12

Research progress on mesenchymal stem cell in treatment of ischemic-type biliary lesion

More Information
  • 摘要: 目前,缺血性胆道损伤(ITBL)的临床治疗仍以外科手术、内镜治疗等方法为主,具有治疗策略单一、治疗方法难度大和医疗费用高的缺点,亟需寻找一种新的治疗策略。间充质干细胞(MSC)具有高度的自我更新能力、多向分化潜能、低免疫原性及免疫调节作用等特性,已然成为再生医学中组织和器官修复的潜在种子细胞。近年来众多研究发现,MSC移植到ITBL动物模型后,不但可归巢到损伤区域,而且可通过抗凋亡、促血管新生等作用促进损伤胆道组织的修复,这表明MSC移植有望成为治疗ITBL的新策略。本文对MSC的生物学特性、MSC移植治疗ITBL的机制及其临床应用做一综述。

     

  • [1] DOBRINDT EM, EURICH D, VELTZKE-SCHLIEKER W, et al. Ischemic-type biliary lesions after liver transplant: factors causing early-onset versus late-onset disease[J]. Exp Clin Transplant, 2020, 18(5): 591-597. DOI: 10.6002/ect.2020.0032.
    [2] TIMANER M, TSAI KK, SHAKED Y. The multifaceted role of mesenchymal stem cells in cancer[J]. Semin Cancer Biol, 2020, 60: 225-237. DOI: 10.1016/j.semcancer.2019.06.003.
    [3] ZHANG S, ZHANG W, LI Y, et al. Cotransplantation of human umbilical cord mesenchymal stem cells and endothelial cells for angiogenesis and pulp regeneration in vivo[J]. Life Sci, 2020, 255: 117763. DOI: 10.1016/j.lfs.2020.117763.
    [4] 李宪哲, 谢明颢, 练磊. 间充质干细胞治疗炎症性肠病的应用及前景[J/CD]. 中华细胞与干细胞杂志(电子版), 2019, 9(4): 236-241. DOI: 10.3877/cma.j.issn.2095-1221.2019.04.008.

    LI XZ, XIE MH, LIAN L. Application and prospect of mesenchymal stem cells in treatment of inflammatory bowel disease[J/CD]. Chin J Cell Stem Cell (Electr Edit), 2019, 9(4): 236-241. DOI: 10.3877/cma.j.issn.2095-1221.2019.04.008.
    [5] CHANG HH, HSU SP, CHIEN CT. Intrarenal transplantation of hypoxic preconditioned mesenchymal stem cells improves glomerulonephritis through anti-oxidation, anti-ER stress, anti-inflammation, anti-apoptosis, and anti-autophagy[J]. Antioxidants (Basel), 2019, 9(1): 2. DOI: 10.3390/antiox9010002.
    [6] BELDI G, KHOSRAVI M, ABDELGAWAD ME, et al. TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function[J]. Stem Cell Res Ther, 2020, 11(1): 281. DOI: 10.1186/s13287-020-01740-5.
    [7] 洪俊杰, 张振阳, 林江波, 等. 血红素加氧酶-1修饰间充质干细胞治疗肺移植缺血再灌注损伤的研究[J]. 中华实验外科杂志, 2019, 36(12): 2231-2233.

    HONG JJ, ZHANG ZY, LIN JB, et al. Heme oxygenase-1 modified mesenchymal stem cells in the treatment of ischemia-reperfusion injury in lung transplantation[J]. Chin J Exp Surg, 2019, 36(12): 2231-2233.
    [8] KAWAKUBO K, OHNISHI S, KUWATANI M, et al. Mesenchymal stem cell therapy for acute and chronic pancreatitis[J]. J Gastroenterol, 2018, 53(1): 1-5. DOI: 10.1007/s00535-017-1363-9.
    [9] WANG J, CHEN Z, DAI Q, et al. Intravenously delivered mesenchymal stem cells prevent microvascular obstruction formation after myocardial ischemia/reperfusion injury[J]. Basic Res Cardiol, 2020, 115(4): 40. DOI: 10.1007/s00395-020-0800-8.
    [10] YIN F, WANG WY, JIANG WH. Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: from biological characteristics to therapeutic mechanisms[J]. World J Stem Cells, 2019, 11(8): 548-564. DOI: 10.4252/wjsc.v11.i8.548.
    [11] LI S, WANG Y, WANG Z, et al. Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis[J]. Stem Cell Res Ther, 2021, 12(1): 27. DOI: 10.1186/s13287-020-02049-z.
    [12] KRISTJÁNSSON B, HONSAWEK S. Mesenchymal stem cells for cartilage regeneration in osteoarthritis[J]. World J Orthop, 2017, 8(9): 674-680. DOI: 10.5312/wjo.v8.i9.674.
    [13] BAO R, XU P, WANG Y, et al. Bone marrow derived mesenchymal stem cells transplantation rescues premature ovarian insufficiency induced by chemotherapy[J]. Gynecol Endocrinol, 2018, 34(4): 320-326. DOI: 10.1080/09513590.2017.1393661.
    [14] SIBOV TT, SEVERINO P, MARTI LC, et al. Mesenchymal stem cells from umbilical cord blood: parameters for isolation, characterization and adipogenic differentiation[J]. Cytotechnology, 2012, 64(5): 511-521. DOI: 10.1007/s10616-012-9428-3.
    [15] SZYDLAK R. Mesenchymal stem cells' homing and cardiac tissue repair[J]. Acta Biochim Pol, 2019, 66(4): 483-489. DOI: 10.18388/abp.2019_2890.
    [16] CUI Y, MADEDDU P. The role of chemokines, cytokines and adhesion molecules in stem cell trafficking and homing[J]. Curr Pharm Des, 2011, 17(30): 3271-3279. DOI: 10.2174/138161211797904109.
    [17] GUGJOO MB, HUSSAIN S, AMARPAL, et al. Mesenchymal stem cell-mediated immuno-modulatory and anti- inflammatory mechanisms in immune and allergic disorders[J]. Recent Pat Inflamm Allergy Drug Discov, 2020, 14(1): 3-14. DOI: 10.2174/1872213X14666200130100236.
    [18] AYALA-CUELLAR AP, KANG JH, JEUNG EB, et al. Roles of mesenchymal stem cells in tissue regeneration and immunomodulation[J]. Biomol Ther (Seoul), 2019, 27(1): 25-33. DOI: 10.4062/biomolther.2017.260.
    [19] WHEAT WH, CHOW L, KURIHARA JN, et al. Suppression of canine dendritic cell activation/maturation and inflammatory cytokine release by mesenchymal stem cells occurs through multiple distinct biochemical pathways[J]. Stem Cells Dev, 2017, 26(4): 249-262. DOI: 10.1089/scd.2016.0199.
    [20] QI K, LI N, ZHANG Z, et al. Tissue regeneration: the crosstalk between mesenchymal stem cells and immune response[J]. Cell Immunol, 2018, 326: 86-93. DOI: 10.1016/j.cellimm.2017.11.010.
    [21] 王媞尔, 史明霞. 间充质干细胞旁分泌作用的研究进展[J]. 实用医学杂志, 2021, 37(13): 1651-1654. DOI: 10.3969/j.issn.1006-5725.2021.13.001.

    WANG TE, SHI MX. Research advance in paracrine role of mesenchymal stem cells[J]. J Pract Med, 2021, 37(13): 1651-1654. DOI: 10.3969/j.issn.1006-5725.2021.13.001.
    [22] 徐芹芹, 格日力, 孙慧燕, 等. 间充质干细胞促血管新生的研究进展[J]. 中国实验血液学杂志, 2017, 25(4): 1267-1270. https://www.cnki.com.cn/Article/CJFDTOTAL-XYSY201704061.htm

    XU QQ, GE RL, SUN HY, et al. Research advance on promoting angiogenesis of mesenchymal stem cells[J]. J Exp Hematol, 2017, 25(4): 1267-1270. https://www.cnki.com.cn/Article/CJFDTOTAL-XYSY201704061.htm
    [23] SAEEDI M, NEZHAD MS, MEHRANFAR F, et al. Biological aspects and clinical applications of mesenchymal stem cells: key features you need to be aware of[J]. Curr Pharm Biotechnol, 2021, 22(2): 200-215. DOI: 10.2174/1389201021666200907121530.
    [24] 吕俊生, 陈大志, 秦建民, 等. 骨髓单个核细胞局部移植预防缺血性胆道狭窄的实验研究[J]. 中华肝胆外科杂志, 2008, 14(4): 251-254. DOI: 10.3760/cma.j.issn.1007-8118.2008.04.014.

    LYU JS, CHEN DZ, QIN JM, et al. Experimental study on bone marrow mononuclear cells on vWF and VEGF expression in ischemic bile duct tissue[J]. Chin J Hepatobiliary Surg, 2008, 14(4): 251-254. DOI: 10.3760/cma.j.issn.1007-8118.2008.04.014.
    [25] 王桥, 宋伟峰, 易述红, 等. 人脐带间充质干细胞移植预防兔缺血性胆道病变的初步实验研究[J]. 器官移植, 2012, 3(3): 127-132. DOI: 10.3969/j.issn.1674-7445.2012.03.002.

    WANG Q, SONG WF, YI SH, et al. Effect of human umbilical cord-derived mesenchymal stem cells transplantation on ischemic-type biliary lesions rabbit model[J]. Organ Transplant, 2012, 3(3): 127-132. DOI: 10.3969/j.issn.1674-7445.2012.03.002.
    [26] LU W, SI YI, DING J, et al. Mesenchymal stem cells attenuate acute ischemia-reperfusion injury in a rat model[J]. Exp Ther Med, 2015, 10(6): 2131-2137. DOI: 10.3892/etm.2015.2806.
    [27] ZHOU C, ZHOU L, LIU J, et al. Kidney extracellular matrix hydrogel enhances therapeutic potential of adipose-derived mesenchymal stem cells for renal ischemia reperfusion injury[J]. Acta Biomater, 2020, 115: 250-263. DOI: 10.1016/j.actbio.2020.07.056.
    [28] HUANG Y, LIU Z, TAN F, et al. Effects of the insulted neuronal cells-derived extracellular vesicles on the survival of umbilical cord-derived mesenchymal stem cells following cerebral ischemia/reperfusion injury[J]. Oxid Med Cell Longev, 2020: 9768713. DOI: 10.1155/2020/9768713.
    [29] ISBAMBETOV A, BAIMAKHANOV Z, SOYAMA A, et al. Equal distribution of mesenchymal stem cells after hepatic ischemia-reperfusion injury[J]. J Surg Res, 2016, 203(2): 360-367. DOI: 10.1016/j.jss.2016.03.057.
    [30] 赵德芳, 陈大志. 骨髓间充质干细胞移植于大鼠缺血性损伤胆道组织后表达血管内皮细胞表型[J/CD]. 中华临床医师杂志(电子版), 2011, 5(20): 5964-5968. DOI: 10.3877/cma.j.issn.1674-0785.2011.20.022.

    ZHAO DF, CHEN DZ. Mesenchymal stem cells differentiate into an endothelial phenotype after transplanted into biliary ischemic lesion in rats[J/CD]. Chin J Clin (Electr Edit), 2011, 5(20): 5964-5968. DOI: 10.3877/cma.j.issn.1674-0785.2011.20.022.
    [31] KONG D, ZHU J, LIU Q, et al. Mesenchymal stem cells protect neurons against hypoxic-ischemic injury via inhibiting parthanatos, necroptosis, and apoptosis, but not autophagy[J]. Cell Mol Neurobiol, 2017, 37(2): 303-313. DOI: 10.1007/s10571-016-0370-3.
    [32] 朱国松, 王广治, 王开伟. 骨髓Sca-1间充质干细胞对肺移植后急性肺损伤的影响[J]. 实用医学杂志, 2020, 36(22): 3065-3068. DOI: 10.3969/j.issn.1006-5725.2020.22.007.

    ZHU GS, WANG GZ, WANG KW. Effect of bone Sca-1 marrow mesenchymal stem cells on acute lung injury after lung transplantation[J]. J Pract Med, 2020, 36(22): 3065-3068. DOI: 10.3969/j.issn.1006-5725.2020.22.007.
    [33] 赵德芳, 陈大志. 骨髓间充质干细胞移植对胆道缺血性狭窄的防治作用研究[J]. 中国普通外科杂志, 2011, 20(8): 823-826. https://www.cnki.com.cn/Article/CJFDTOTAL-ZPWZ201108009.htm

    ZHAO DF, CHEN DZ. Study of the protective effect of mesenchymal stem cells transplantation on ischemic biliary stricture[J]. Chin J Gen Surg, 2011, 20(8): 823-826. https://www.cnki.com.cn/Article/CJFDTOTAL-ZPWZ201108009.htm
    [34] CAI Y, ZOU Z, LIU L, et al. Bone marrow-derived mesenchymal stem cells inhibits hepatocyte apoptosis after acute liver injury[J]. Int J Clin Exp Pathol, 2015, 8(1): 107-116.
    [35] LI KS, JIANG WP, LI QC, et al. MiR-29a in mesenchymal stem cells inhibits FSTL1 secretion and promotes cardiac myocyte apoptosis in hypoxia-reoxygenation injury[J]. Cardiovasc Pathol, 2020, 46: 107180. DOI: 10.1016/j.carpath.2019.107180.
    [36] 王永, 王向昱, 李立军, 等. TGF-β1、CTGF在胆管缺血性损伤修复过程中的表达及意义[J]. 中国现代医生, 2012, 50(4): 6-8. DOI: 10.3969/j.issn.1673-9701.2012.04.003.

    WANG Y, WANG XY, LI LJ, et al. Expression and significance of TGF-β1 and CTGF in the repairing process of bile duct ischemic injury[J]. China Mod Dr, 2012, 50(4): 6-8. DOI: 10.3969/j.issn.1673-9701.2012.04.003.
    [37] LI K, SHI C, HUANG J, et al. Dexamethasone effect on the expression of transforming growth factor-β1/Smads signaling pathway in benign biliary stricture fibroblasts in rodent[J]. J Coll Physicians Surg Pak, 2017, 27(3): 131-134.
    [38] XUAN J, FENG W, AN ZT, et al. Anti-TGFβ-1 receptor inhibitor mediates the efficacy of the human umbilical cord mesenchymal stem cells against liver fibrosis through TGFβ-1/Smad pathway[J]. Mol Cell Biochem, 2017, 429(1/2): 113-122. DOI: 10.1007/s11010-017-2940-1.
    [39] LI X, AN G, WANG Y, et al. Targeted migration of bone marrow mesenchymal stem cells inhibits silica-induced pulmonary fibrosis in rats[J]. Stem Cell Res Ther, 2018, 9(1): 335. DOI: 10.1186/s13287-018-1083-y.
    [40] WU L, RONG C, ZHOU Q, et al. Bone marrow mesenchymal stem cells ameliorate cisplatin-induced renal fibrosis via miR-146a-5p/Tfdp2 axis in renal tubular epithelial cells[J]. Front Immunol, 2021, 11: 623693. DOI: 10.3389/fimmu.2020.623693.
    [41] PENG Y, CHEN X, LIU Q, et al. Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10[J]. Leukemia, 2015, 29(3): 636-646. DOI: 10.1038/leu.2014.225.
    [42] OH JY, LEE RH. Mesenchymal stromal cells for the treatment of ocular autoimmune diseases[J]. Prog Retin Eye Res, 2021, DOI: 10.1016/j.preteyeres.2021.100967[Epubaheadofprint].
    [43] JIANG W, XU J. Immune modulation by mesenchymal stem cells[J]. Cell Prolif, 2020, 53(1): e12712. DOI: 10.1111/cpr.12712.
    [44] ZHANG YC, LIU W, FU BS, et al. Therapeutic potentials of umbilical cord-derived mesenchymal stromal cells for ischemic-type biliary lesions following liver transplantation[J]. Cytotherapy, 2017, 19(2): 194-199. DOI: 10.1016/j.jcyt.2016.11.005.
  • 加载中
图(1)
计量
  • 文章访问数:  56
  • HTML全文浏览量:  15
  • PDF下载量:  14
  • 被引次数: 0
出版历程
  • 收稿日期:  2021-07-15
  • 刊出日期:  2021-11-15

目录

    /

    返回文章
    返回