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枯否细胞极化状态在肝移植免疫耐受中的作用

刘涛 李金政

刘涛, 李金政. 枯否细胞极化状态在肝移植免疫耐受中的作用[J]. 器官移植, 2021, 12(6): 687-691. doi: 10.3969/j.issn.1674-7445.2021.06.007
引用本文: 刘涛, 李金政. 枯否细胞极化状态在肝移植免疫耐受中的作用[J]. 器官移植, 2021, 12(6): 687-691. doi: 10.3969/j.issn.1674-7445.2021.06.007
Liu Tao, Li Jinzheng. Role of Kupffer cell polarization in immune tolerance of liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 687-691. doi: 10.3969/j.issn.1674-7445.2021.06.007
Citation: Liu Tao, Li Jinzheng. Role of Kupffer cell polarization in immune tolerance of liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 687-691. doi: 10.3969/j.issn.1674-7445.2021.06.007

枯否细胞极化状态在肝移植免疫耐受中的作用

doi: 10.3969/j.issn.1674-7445.2021.06.007
基金项目: 

国家自然科学基金面上项目 81671580

详细信息
    作者简介:

    刘涛,男,1997年生,硕士研究生,研究方向为肝移植,Email:921482342@qq.com

    通讯作者:

    李金政,男,1983年生,博士,副主任医师,研究方向为肝移植与免疫耐受,Email:vitamin198305@163.com

  • 中图分类号: R617, R392.4

Role of Kupffer cell polarization in immune tolerance of liver transplantation

More Information
  • 摘要: 随着外科手术技术的成熟,肝移植手术成功率逐渐提高,然而术后长期免疫耐受的建立仍然面临着许多问题。枯否(Kupffer)细胞是一种组织驻留型巨噬细胞,常驻于肝脏当中,其可在肝移植术后向着不同方向极化,形成M1型Kupffer细胞和M2型Kupffer细胞。M1型Kupffer细胞具有促炎功能,M2型Kupffer细胞具有免疫调节功能。通过抑制M1型Kupffer细胞数量和功能,或者促使M2型Kupffer细胞数量增加和功能增强,有助于免疫耐受的建立。Kupffer细胞的极化受到诸多细胞因子和信号的调节,这为通过干预Kupffer细胞极化来建立肝移植免疫耐受的疗法提供了机会。本文将就Kupffer细胞极化状态与肝移植免疫耐受的关系、Kupffer细胞极化机制进行综述,旨在为建立肝移植免疫耐受提供参考。

     

  • 图  1  Kupffer细胞的极化机制

    注:SAHA为异羟肟酸;α-KG为α-酮戊二酸;TLR4为Toll样受体4;MyD88为髓样分化因子88;PI3K为磷脂酰肌醇-3-激酶;Akt为蛋白激酶B;NF-κB为核因子-κB;GSK3β为糖原合酶激酶3β;TRIF为β干扰素诱导的含TIR结构域接头蛋白。

    Figure  1.  The polarization mechanism of Kupffer cell

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出版历程
  • 收稿日期:  2021-08-10
  • 刊出日期:  2021-11-15

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