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淋巴细胞亚群分类对肾移植受者活动性肺结核的诊断价值

易王 成柯

易王, 成柯. 淋巴细胞亚群分类对肾移植受者活动性肺结核的诊断价值[J]. 器官移植, 2020, 11(5): 605-609. doi: 10.3969/j.issn.1674-7445.2020.05.013
引用本文: 易王, 成柯. 淋巴细胞亚群分类对肾移植受者活动性肺结核的诊断价值[J]. 器官移植, 2020, 11(5): 605-609. doi: 10.3969/j.issn.1674-7445.2020.05.013
Yi Wang, Cheng Ke. Diagnostic value of lymphocyte subset classification for active pulmonary tuberculosis in renal transplant recipients[J]. ORGAN TRANSPLANTATION, 2020, 11(5): 605-609. doi: 10.3969/j.issn.1674-7445.2020.05.013
Citation: Yi Wang, Cheng Ke. Diagnostic value of lymphocyte subset classification for active pulmonary tuberculosis in renal transplant recipients[J]. ORGAN TRANSPLANTATION, 2020, 11(5): 605-609. doi: 10.3969/j.issn.1674-7445.2020.05.013

淋巴细胞亚群分类对肾移植受者活动性肺结核的诊断价值

doi: 10.3969/j.issn.1674-7445.2020.05.013
基金项目: 湖南省自然科学基金(S2017JJMSXM1518)
详细信息
    作者简介:

    易王,男,1995年生,硕士研究生,研究方向为器官移植与术后管理,Email:yiwang1995@csu.edu.com

    通讯作者:

    成柯,男,1972年生,博士,主任医师,研究方向为器官移植与术后管理,Email:chke1972@163.com

  • 中图分类号: R617, R521

Diagnostic value of lymphocyte subset classification for active pulmonary tuberculosis in renal transplant recipients

More Information
  • 摘要:   目的  探讨淋巴细胞亚群分类在诊断肾移植受者活动性肺结核中的临床价值。  方法  回顾性分析52例肾移植术后受者的临床资料。根据影像学检查和病原学检查结果,将52例受者分为稳定组(19例)、结核组(9例)、细菌组(12例)以及真菌组(12例)。比较各组受者的肾功能情况;分析并比较各组受者淋巴细胞亚群的比例和绝对值;分析淋巴细胞亚群分类在肾移植术后活动性肺结核中的诊断价值。  结果  与稳定组比较,结核组、细菌组、真菌组的血尿素氮和血清肌酐水平均明显升高(均为P<0.05),CD3+、CD8+、CD4+、自然杀伤(NK)细胞和CD19+淋巴细胞亚群的比例差异无统计学意义(均为P>0.05),CD3+、CD8+、CD4+、NK和CD19+淋巴细胞亚群的绝对值明显降低(均为P<0.05)。结核组和真菌组的CD8+淋巴细胞亚群比例明显高于细菌组(均为P<0.05)。CD8+淋巴细胞亚群比例在鉴别诊断肾移植受者活动性肺结核和细菌性肺炎中的最佳临界值是33.27%,灵敏度和特异度分别为0.889和0.833,曲线下面积(AUC)为0.880。  结论  淋巴细胞亚群分类可为肾移植受者活动性肺结核与细菌性肺炎的鉴别诊断和个体化治疗方案提供辅助诊断依据。

     

  • 图  1  各组肾移植受者淋巴细胞亚群的比例和绝对值

    注:与细菌组比较,aP<0.05;与稳定组比较,bP<0.05;与真菌组比较,cP<0.05。

    Figure  1.  Percentage and absolute value of lymphocyte subsets in renal transplant recipients of each group

    图  2  CD8+淋巴细胞亚群比例诊断肾移植受者活动性肺结核的ROC曲线

    Figure  2.  The ROC curve of percentage of CD8+ lymphocyte subsets for diagnosing active tuberculosis in renal transplant recipients

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出版历程
  • 收稿日期:  2020-06-02
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2020-09-15

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