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耐受性树突状细胞在肝移植免疫耐受中的研究进展

杨志琦, 李明皓. 耐受性树突状细胞在肝移植免疫耐受中的研究进展[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2024039
引用本文: 杨志琦, 李明皓. 耐受性树突状细胞在肝移植免疫耐受中的研究进展[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2024039
Yang Zhiqi, Li Minghao. Research progress in tolerogenic dendritic cells in immune tolerance of liver transplantation[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024039
Citation: Yang Zhiqi, Li Minghao. Research progress in tolerogenic dendritic cells in immune tolerance of liver transplantation[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024039

耐受性树突状细胞在肝移植免疫耐受中的研究进展

doi: 10.3969/j.issn.1674-7445.2024039
基金项目: 宁夏自然科学基金(2021AAC03308);宁夏回族自治区人民医院科技创新人才项目(院党发〔2023〕72号);宁夏回族自治区人民医院国家自然科学基金预实验项目(2024GZRYSY0015)
详细信息
    作者简介:
    通讯作者:

    李明皓(ORCID 0000-0001-5185-1698),医学博士,主任医师,研究方向为肝移植免疫耐受及肝胆胰肿瘤基础与临床研究,Email:liminghao317@163.com

  • 中图分类号: R617, R392.12

Research progress in tolerogenic dendritic cells in immune tolerance of liver transplantation

More Information
  • 摘要: 肝移植术后排斥反应严重影响受者生存,长期应用免疫抑制药是预防排斥反应的重要手段,但其存在毒性作用,以及会增加全身感染、肿瘤复发等不良事件的风险。因此,在成功肝移植手术之前,如何对受者实施个体化免疫耐受诱导,实现术后免疫抑制药完全或早期撤退,仍然是器官移植工作者不断探索的研究方向。近年来,耐受性树突状细胞诱导肝移植免疫耐受的机制研究取得了一些新的进展,临床试验初显成效。本文就耐受性树突状细胞的特征、参与重塑肝脏免疫微环境的机制及其诱导肝移植免疫耐受基础研究与临床应用进展进行综述,以期为耐受性树突状细胞在肝移植免疫耐受中的应用研究提供参考。

     

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  • 收稿日期:  2024-02-07
  • 网络出版日期:  2024-04-28

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