异种移植中猪内源性逆转录病毒的传播

余一凡; 宋佳华; 宋相钦; 李涛; 江建; 白云昊; 王毅

doi:10.3969/j.issn.1674-7445.2023293

异种移植中猪内源性逆转录病毒的传播

doi: 10.3969/j.issn.1674-7445.2023293

余一凡^1,,
宋佳华²,
宋相钦¹,
李涛¹,
江建¹,
白云昊¹,
王毅^1, ,

1.
570216　海口，海南医学院第二附属医院移植研究所
2.
南华大学附属第二医院泌尿外科

基金项目: 国家自然科学基金（82260154）；海南省卫生计生行业科研项目（20A200360）；海南省科技厅自然科学基金（820RC766）；海南医学院2021年度研究生创新科研课题（HYYS2021B0）

详细信息

作者简介:

通讯作者:
王毅（ORCID：0000-0001-7152-0757），医学博士、二级教授、一级主任医师、博士研究生导师，研究方向为外科学、异种移植，Email：wayne0108@126.com

中图分类号: R617, Q527+.5
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- 被引次数: 0
出版历程
- 收稿日期: 2023-04-30
- 录用日期: 2023-07-10
- 网络出版日期: 2023-07-20
- 刊出日期: 2023-09-15

Transmission of porcine endogenous retrovirus in xenotransplantation

1.
Transplantation Institute, the Second Affiliated Hospital of Hainan Medical University, Hainan 570216, China

More Information

Corresponding author: Wang Yi, Email:wayne0108@126.com

摘要

摘要: 器官移植是治疗各类终末期疾病最有效的手段，为了解决器官移植中供体短缺的问题，人们开始探究异种移植的可能。猪是异种器官移植常见的供体来源之一，猪器官作为连接两个物种间的桥梁，其携带的病毒有可能在物种间传播并存在引起人畜共患病的风险。猪内源性逆转录病毒（PERV）整合在基因组中，是一种跨物种传播的逆转录病毒。本文介绍了PERV传播特性的影响因素、PERV及其重组病毒的传播风险以及异种移植试验中PERV的检测与传播风险评估，以期为缓解器官移植供体严重短缺的现状，推动异种移植技术的发展提供参考。
- 异种移植 /
- 猪内源性逆转录病毒 /
- 器官短缺 /
- 转基因 /
- 传播特性 /
- 人畜共患病 /
- 免疫缺陷 /
- 感染
Abstract: Organ transplantation is the most effective treatment for various types of end-stage diseases. To resolve the problem of donor shortage in organ transplantation, the possibility of xenotransplantation has been gradually explored by surgeons. Pig is one of the common donor sources for xenotransplantation. As a bridge between two species, the viruses carried by pig organs may be transmitted between species and cause the risk of zoonosis. Porcine endogenous retrovirus (PERV) is integrated into the genome, which is a category of retrovirus featuring cross-species transmission. In this article, the influencing factors of transmission characteristics of PERV, the transmission risk of PERV and its recombinant virus, and the detection and transmission risk assessment of PERV in xenotransplantation test were reviewed, aiming to provide reference for alleviating severe shortage of donor organs and driving the advancement of xenotransplantation technologies.
- Xenotransplantation /
- Porcine endogenous retrovirus /
- Organ shortage /
- Transgene /
- Transmission characteristics /
- Zoonosis /
- Immunodeficiency /
- Infection

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