余一凡, 宋佳华, 宋相钦, 等. 异种移植中猪内源性逆转录病毒的传播[J]. 器官移植, 2023, 14(5): 754-759. DOI: 10.3969/j.issn.1674-7445.2023293
引用本文: 余一凡, 宋佳华, 宋相钦, 等. 异种移植中猪内源性逆转录病毒的传播[J]. 器官移植, 2023, 14(5): 754-759. DOI: 10.3969/j.issn.1674-7445.2023293
Yu Yifan, Song Jiahua, Song Xiangqin, et al. Transmission of porcine endogenous retrovirus in xenotransplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 754-759. DOI: 10.3969/j.issn.1674-7445.2023293
Citation: Yu Yifan, Song Jiahua, Song Xiangqin, et al. Transmission of porcine endogenous retrovirus in xenotransplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 754-759. DOI: 10.3969/j.issn.1674-7445.2023293

异种移植中猪内源性逆转录病毒的传播

Transmission of porcine endogenous retrovirus in xenotransplantation

  • 摘要: 器官移植是治疗各类终末期疾病最有效的手段,为了解决器官移植中供体短缺的问题,人们开始探究异种移植的可能。猪是异种器官移植常见的供体来源之一,猪器官作为连接两个物种间的桥梁,其携带的病毒有可能在物种间传播并存在引起人畜共患病的风险。猪内源性逆转录病毒(PERV)整合在基因组中,是一种跨物种传播的逆转录病毒。本文介绍了PERV传播特性的影响因素、PERV及其重组病毒的传播风险以及异种移植试验中PERV的检测与传播风险评估,以期为缓解器官移植供体严重短缺的现状,推动异种移植技术的发展提供参考。

     

    Abstract: Organ transplantation is the most effective treatment for various types of end-stage diseases. To resolve the problem of donor shortage in organ transplantation, the possibility of xenotransplantation has been gradually explored by surgeons. Pig is one of the common donor sources for xenotransplantation. As a bridge between two species, the viruses carried by pig organs may be transmitted between species and cause the risk of zoonosis. Porcine endogenous retrovirus (PERV) is integrated into the genome, which is a category of retrovirus featuring cross-species transmission. In this article, the influencing factors of transmission characteristics of PERV, the transmission risk of PERV and its recombinant virus, and the detection and transmission risk assessment of PERV in xenotransplantation test were reviewed, aiming to provide reference for alleviating severe shortage of donor organs and driving the advancement of xenotransplantation technologies.

     

/

返回文章
返回