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异种肾移植的亚临床研究进展

陈羽翔, 李卓骋, 李涛, 等. 异种肾移植的亚临床研究进展[J]. 器官移植, 2024, 15(1): 10-18. doi: 10.3969/j.issn.1674-7445.2023256
引用本文: 陈羽翔, 李卓骋, 李涛, 等. 异种肾移植的亚临床研究进展[J]. 器官移植, 2024, 15(1): 10-18. doi: 10.3969/j.issn.1674-7445.2023256
Chen Yuxiang, Li Zhuocheng, Li Tao, et al. Progress in subclinical research of kidney xenotransplantation[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 10-18. doi: 10.3969/j.issn.1674-7445.2023256
Citation: Chen Yuxiang, Li Zhuocheng, Li Tao, et al. Progress in subclinical research of kidney xenotransplantation[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 10-18. doi: 10.3969/j.issn.1674-7445.2023256

异种肾移植的亚临床研究进展

doi: 10.3969/j.issn.1674-7445.2023256
基金项目: 国家自然科学基金(82260154);海南省重大科技项目(ZDKJ2019009);海南省自然科学基金(820RC766、821QN413、821QN409);海南省临床医学中心建设项目;海南省研究生创新科研课题(Qhys2022-227);海南医学院研究生创新科研A类课题(HYYB2022A07)
详细信息
    作者简介:
    通讯作者:

    蒋鸿涛(ORCID 0000-0001-9716-3233),Email:jht20032003@163.com

  • 中图分类号: R617, Q78

Progress in subclinical research of kidney xenotransplantation

More Information
  • 摘要: 异种移植是目前解决临床器官来源短缺的有效途径之一。随着基因编辑技术及免疫抑制方案不断发展,猪-非人灵长类动物异种肾移植相关研究取得了显著进展,为开启异种肾移植临床应用创造了良好条件。鉴于人与非人灵长类动物实质性差异,同时为了满足现阶段的伦理学要求,猪-人异种肾移植的亚临床研究非常必要。近年来,已有关于基因修饰猪-脑死亡受者异种肾移植的亚临床研究,表明异种肾移植已经进入向临床发展的过渡阶段。然而,供受体选择及免疫抑制应用方案尚未统一,亟需在亚临床研究中进一步明确。本文就异种肾移植亚临床研究中供受体选择、免疫抑制方案、移植术后监测管理等方面的现状和当前面临的主要问题进行综述,以期推动异种肾移植向临床转化。

     

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出版历程
  • 收稿日期:  2023-11-20
  • 网络出版日期:  2023-12-12
  • 刊出日期:  2024-01-11

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