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间充质干细胞疗法在肾移植中的应用：一个未完待续的故事

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谢思雨, 路君. 间充质干细胞疗法在肾移植中的应用：一个未完待续的故事[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2023228
引用本文: 谢思雨, 路君. 间充质干细胞疗法在肾移植中的应用：一个未完待续的故事[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2023228
shu
Xie Siyu, Lu Jun. Application of mesenchymal stem cell therapy in kidney transplantation: a continued story[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2023228
Citation: Xie Siyu, Lu Jun. Application of mesenchymal stem cell therapy in kidney transplantation: a continued story[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2023228
shu

间充质干细胞疗法在肾移植中的应用：一个未完待续的故事

doi: 10.3969/j.issn.1674-7445.2023228

  • 350025　福州，中国人民解放军联勤保障部队第九〇〇医院 福建省移植生物学重点实验室

基金项目: 福建省自然科学基金面上项目（2023J01207）；中国人民解放军联勤保障部队第九〇〇医院重点学科支撑项目（2023XKYZ01）
详细信息
    作者简介:
    通讯作者:

    路君（ORCID 0000-0003-2221-1872），博士，副主任技师，研究方向为肾脏损伤与修复，Email：junlu.heather@xmu.edu.cn

  • 中图分类号: R617,R329.2

Application of mesenchymal stem cell therapy in kidney transplantation: a continued story

  • The 900th Hospital of the Joint Logistics Support Force of Chinese People's Liberation Army, Fujian Provincial Key Laboratory of Transplantation Biology, Fuzhou 350025, China

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    摘要
  • 摘要: 免疫抑制药是预防器官移植术后排斥反应的主要手段，但会降低机体对病原体的反应能力，导致感染等的风险增加。近年来，间充质干细胞（MSC）疗法在实体器官移植领域的应用备受关注。临床前研究表明，MSC疗法能够延长移植肾存活时间，诱导免疫耐受，加速急性肾损伤修复，促进肾功能恢复。临床试验则验证了MSC疗法的安全性、耐受性和有效性。因此，本文对MSC的一般特性、MSC的免疫调节和组织修复作用以及MSC在肾移植临床试验中的应用进行综述，简要讨论待继续研究的问题和对未来的展望，旨在为推动MSC治疗在临床肾移植中的应用提供参考。

     

    Abstract: Immunosuppressant is one of the main preventive measures for rejection after organ transplantation, whereas it may reduce the host response capability to pathogens and increase the risk of infection. In recent years, the application of mesenchymal stem cell (MSC) therapy in the field of solid organ transplantation has attracted widespread attention. Preclinical studies have shown that MSC therapy may prolong the survival time of transplant kidney, induce immune tolerance, accelerate the repair of acute kidney injury and promote the recovery of renal function. Clinical trials have confirmed the safety, tolerance and effectiveness of MSC therapy. Consequently, general characteristics, immunomodulation and tissue repair function of MSC, and the application of MSC in clinical trials of kidney transplantation were reviewed, the unresolved issues were briefly discussed and the prospects for subsequent research were predicted, aiming to provide reference for promoting the application of MSC therapy in clinical kidney transplantation.

     

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  • 收稿日期:  2023-11-02
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