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肺源分配评分与特发性肺纤维化患者肺移植术后早期死亡风险的相关性分析

顾美蓉, 刘民强, 戴韬寅, 等. 肺源分配评分与特发性肺纤维化患者肺移植术后早期死亡风险的相关性分析[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2023200
引用本文: 顾美蓉, 刘民强, 戴韬寅, 等. 肺源分配评分与特发性肺纤维化患者肺移植术后早期死亡风险的相关性分析[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2023200
Gu Meirong, Liu Minqiang, Dai Taoyin, et al. Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2023200
Citation: Gu Meirong, Liu Minqiang, Dai Taoyin, et al. Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2023200

肺源分配评分与特发性肺纤维化患者肺移植术后早期死亡风险的相关性分析

doi: 10.3969/j.issn.1674-7445.2023200
基金项目: 江苏省科技计划重点研发项目(BE2022697);南京医科大学无锡医学中心 专病队列和临床研究项目(WMCC202301);无锡市太湖人才计划国际国内顶尖医学专家 团队(2019-THRCTD-1)
详细信息
    作者简介:
    通讯作者:

    胡春晓(ORCID 0000-0002-4825-0645),主任医师,研究方向为肺缺血-再灌注损伤、重要器官功能保护、ECMO在器官移植中的应用管理,Email: huchunxiao91211@163.com

  • 中图分类号: R617, R563

Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation

More Information
  • 摘要:   目的   分析肺源分配评分(LAS)与特发性肺纤维化(IPF)患者肺移植术后早期死亡风险的相关性。  方法   回顾性分析275例IPF患者临床资料,采用单因素和多因素Cox回归分析LAS与IPF患者肺移植术后早期死亡风险的相关性,以及LAS与术后1年并发症发生的相关性。  结果   275例受者中,术后30、90、180和365 d内分别死亡62例、83例、95例和108例。LAS与IPF患者肺移植术后30、90、180、365 d病死率相关(均为P<0.05),但与术后365 d原发性移植物功能障碍(PGD)、急性肾损伤(AKI)发生无关(均为P>0.05)。  结论   LAS与IPF患者肺移植术后早期死亡相关,LAS与术后早期PGD、AKI的发生无关,但应关注综合因素对PGD、AKI发生的影响。

     

  • 图  1  LAS与术后早期死亡相关性分析

    注:A图为LAS与术后30 d死亡风险相关性;B图为LAS与术后90 d死亡风险相关性;C图为LAS与术后180 d死亡风险相关性;D图为LAS与术后365 d死亡风险相关性。

    Figure  1.  Analysis of the correlation between LAS and early postoperative death

    图  2  LAS与术后并发症相关性分析

    注:A图为LAS与术后365 d PGD相关性分析;B图为LAS与术后365 d AKI相关性分析。

    Figure  2.  Analysis of the correlation between LAS and postoperative complications

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  • 收稿日期:  2023-10-07
  • 网络出版日期:  2023-12-25

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