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国内外异种器官移植的现状及进展

张小燕, 王国辉, 韩士超, 等. 国内外异种器官移植的现状及进展[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2023193
引用本文: 张小燕, 王国辉, 韩士超, 等. 国内外异种器官移植的现状及进展[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2023193
Zhang Xiaoyan, Wang Guohui, Han Shichao, et al. Present situation and progress of xenotransplantation at home and abroad[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2023193
Citation: Zhang Xiaoyan, Wang Guohui, Han Shichao, et al. Present situation and progress of xenotransplantation at home and abroad[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2023193

国内外异种器官移植的现状及进展

doi: 10.3969/j.issn.1674-7445.2023193
基金项目: 国家自然科学基金(82101322、82200845)
详细信息
    作者简介:
    通讯作者:

    窦科峰(ORCID 0000-0003-1708-8048),主任医师,中国科学院院士,研究方向为异种移植与肝胆疾病,Email: doukef@fmmu.edu.cn;秦卫军(ORCID 0000-0001-5202-642X),博士,主任医师,研究方向为肾移植与泌尿系肿瘤,Email: doukef@fmmu.edu.cn

  • 中图分类号: R617,Q78

Present situation and progress of xenotransplantation at home and abroad

More Information
  • 摘要: 器官短缺是阻碍器官移植发展的主要难题,异种移植是解决全球器官匮乏最有价值的方法之一。近年来,基因工程技术的发展和新型免疫抑制药的研发为异种移植提供了新的理论基础。近年来,国外陆续开展基因编辑猪-非人灵长类动物或脑死亡受者的相关异种移植研究,并取得一些实质性的进展,但大部分的研究仍处于临床前阶段,距离投入临床跨越巨大。因此,本文结合目前国内外最新的临床前实验研究进展,对异种移植的历史、基因修饰技术发展、异种排斥反应及免疫抑制方案等问题进行综述,以期为异种移植的进一步研究提供参考,促进异种移植临床应用,造福更多终末期疾病患者。

     

  • 图  1  基因修饰猪-人排斥反应、凝血及炎症反应

    注:PAF-1为1血小板激活因子1,HLA-E为人类白细胞抗原E抗体。

    Figure  1.  Rejection, coagulation and inflammation in genetically modified pig to human

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  • 收稿日期:  2023-12-05
  • 网络出版日期:  2024-01-24

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