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巨噬细胞转分化在肾纤维化中的调控机制

杨艳燕, 陶涛, 罗朋立. 巨噬细胞转分化在肾纤维化中的调控机制[J]. 器官移植, 2024, 15(1): 125-130. doi: 10.3969/j.issn.1674-7445.2023190
引用本文: 杨艳燕, 陶涛, 罗朋立. 巨噬细胞转分化在肾纤维化中的调控机制[J]. 器官移植, 2024, 15(1): 125-130. doi: 10.3969/j.issn.1674-7445.2023190
Yang Yanyan, Tao Tao, Luo Pengli. Regulation mechanism of macrophage transition in renal fibrosis[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 125-130. doi: 10.3969/j.issn.1674-7445.2023190
Citation: Yang Yanyan, Tao Tao, Luo Pengli. Regulation mechanism of macrophage transition in renal fibrosis[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 125-130. doi: 10.3969/j.issn.1674-7445.2023190

巨噬细胞转分化在肾纤维化中的调控机制

doi: 10.3969/j.issn.1674-7445.2023190
基金项目: 青海省科技计划应用基础研究(2022-ZJ-766)
详细信息
    作者简介:
    通讯作者:

    罗朋立(ORCID 0009-0008-2271-2750),博士,教授,主任医师,研究方向为低氧与肾脏病,Email:qhlpl2108@163.com

  • 中图分类号: R617, R329.2

Regulation mechanism of macrophage transition in renal fibrosis

More Information
  • 摘要: 肾纤维化是所有进展性慢性肾病发展至终末期肾病的共同病理改变。肾移植术后发生肾纤维化会严重影响移植肾功能。巨噬细胞具有高度的异质性和可塑性,在肾损伤过程中,受局部微环境刺激被募集、激活和极化,通过多种机制参与肾组织损伤、修复和纤维化的过程。近年来,多项研究表明,巨噬细胞可以转分化为肌成纤维细胞直接参与肾纤维化形成,这一过程被称为巨噬细胞-肌成纤维细胞转分化,但其调控机制尚不清楚。因此,本文就巨噬细胞在肾纤维化中的作用、巨噬细胞-肌成纤维细胞转分化的特点及可能的调控机制进行综述,以期为肾纤维化的相关研究提供参考。

     

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出版历程
  • 收稿日期:  2023-09-26
  • 网络出版日期:  2023-11-29
  • 刊出日期:  2024-01-11

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