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巨噬细胞与缺血-再灌注损伤相关研究进展

刘琦, 张燕楠, 孙启全. 巨噬细胞与缺血-再灌注损伤相关研究进展[J]. 器官移植, 2024, 15(1): 40-45. doi: 10.3969/j.issn.1674-7445.2023161
引用本文: 刘琦, 张燕楠, 孙启全. 巨噬细胞与缺血-再灌注损伤相关研究进展[J]. 器官移植, 2024, 15(1): 40-45. doi: 10.3969/j.issn.1674-7445.2023161
Liu Qi, Zhang Yannan, Sun Qiquan. Research progress on association between macrophages and ischemia-reperfusion injury[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 40-45. doi: 10.3969/j.issn.1674-7445.2023161
Citation: Liu Qi, Zhang Yannan, Sun Qiquan. Research progress on association between macrophages and ischemia-reperfusion injury[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 40-45. doi: 10.3969/j.issn.1674-7445.2023161

巨噬细胞与缺血-再灌注损伤相关研究进展

doi: 10.3969/j.issn.1674-7445.2023161
基金项目: 国家自然科学基金面上项目(82270783)
详细信息
    作者简介:
    通讯作者:

    孙启全(ORCID 0000-0002-7296-316X),博士,教授,研究方向为移植免疫,Email: sunqiquan@gdph.org.cn

  • 中图分类号: R617, R329.2

Research progress on association between macrophages and ischemia-reperfusion injury

More Information
  • 摘要: 缺血-再灌注损伤(IRI)是一个极其复杂的病理生理过程,可在心肌梗死、卒中、器官移植、涉及暂时中断血流的手术等过程中发生。巨噬细胞作为免疫系统的关键分子,在IRI的发病机制中起着至关重要的作用。M1型巨噬细胞是促炎细胞,参与病原体的清除;而M2型巨噬细胞具有抗炎作用,参与组织修复和重塑以及细胞外基质重塑。巨噬细胞表型之间的平衡对于IRI的结局和治疗十分重要。本文综述了巨噬细胞在IRI中的作用,包括巨噬细胞M1/M2表型平衡、向不同缺血组织浸润和募集的机制。此外,还讨论了IRI过程中靶向巨噬细胞的潜在治疗策略,为减轻IRI和促进组织修复相关研究提供参考。

     

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出版历程
  • 收稿日期:  2023-08-16
  • 网络出版日期:  2023-11-29
  • 刊出日期:  2024-01-11

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