董骏峰, 薛强, 滕飞, 等. 移植后糖尿病危险因素研究进展[J]. 器官移植, 2024, 15(1): 145-150. DOI: 10.3969/j.issn.1674-7445.2023154
引用本文: 董骏峰, 薛强, 滕飞, 等. 移植后糖尿病危险因素研究进展[J]. 器官移植, 2024, 15(1): 145-150. DOI: 10.3969/j.issn.1674-7445.2023154
Dong Junfeng, Xue Qiang, Teng Fei, et al. Research progress in risk factors of post-transplantation diabetes mellitus[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 145-150. DOI: 10.3969/j.issn.1674-7445.2023154
Citation: Dong Junfeng, Xue Qiang, Teng Fei, et al. Research progress in risk factors of post-transplantation diabetes mellitus[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 145-150. DOI: 10.3969/j.issn.1674-7445.2023154

移植后糖尿病危险因素研究进展

Research progress in risk factors of post-transplantation diabetes mellitus

  • 摘要: 实体器官移植极大地延长了终末期疾病患者的生存时间,但器官移植受者术后需要长期服用免疫抑制药,会导致移植后糖尿病(PTDM)的发生风险增加,从而使感染、心血管疾病和死亡的风险升高。近年来,随着PTDM诊断标准的不断完善,临床医师对其认识越来越深入,与2型糖尿病相比,PTDM在病理生理特征和临床进展上存在着明显差异,需采用不同的治疗策略。及早识别器官移植受者的危险因素,早期诊断和干预对于改善受者的生活质量,延长移植物的存活时间以及降低受者病死率具有重要意义。因此,本文就PTDM的诊断、发生情况及危险因素做一综述,以期为临床医师早期识别并干预PTDM提供参考。

     

    Abstract: Solid organ transplantation has significantly prolonged the survival of patients with end-stage diseases. However, long-term use of immunosuppressants will increase the risk of post-transplantation diabetes mellitus (PTDM) in the recipients, thereby elevating the risk of infection, cardiovascular disease and death. In recent years, with persistent improvement of diagnostic criteria of PTDM, clinicians have deepened the understanding of this disease. Compared with type 2 diabetes mellitus, PTDM significantly differs in pathophysiological characteristics and clinical progression. Hence, different treatment strategies should be adopted. Early identification of risk factors of organ transplant recipients, early diagnosis and intervention are of significance for improving the quality of life of recipients, prolonging the survival of grafts and reducing the fatality of recipients. Therefore, the diagnosis, incidence and risk factors of PTDM were reviewed in this article, aiming to provide reference for clinicians to deliver prompt diagnosis and intervention for PTDM.

     

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