移植肾功能丧失受者的临床管理策略

杨昊; 林俊; 张健

doi:10.3969/j.issn.1674-7445.2023149

移植肾功能丧失受者的临床管理策略

doi: 10.3969/j.issn.1674-7445.2023149

100050　北京，首都医科大学附属北京友谊医院泌尿外科

基金项目: 国家自然科学基金（82000712）

详细信息

作者简介:

通讯作者:
林俊（ORCID 0000-0002-68847-7150），博士，主任医师，研究方向为泌尿外科，Email：bfhlinjun@hotmail.com

中图分类号: R617, R692
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出版历程
- 收稿日期: 2023-07-31
- 网络出版日期: 2023-09-27
- 刊出日期: 2024-01-11

Clinical management strategies for recipients with renal graft loss

Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

More Information

Corresponding author: Lin Jun, Email: bfhlinjun@hotmail.com

摘要

摘要: 随着肾移植手术技术的成熟和新型免疫抑制药的引入以及免疫抑制方案的改进，肾移植受者的短期生存率已显著提高，但长期生存并未得到显著改善。肾移植受者通常可能面临移植肾功能丧失。移植肾功能丧失后的医疗管理较为复杂，包括免疫抑制药的调整、移植肾的处理以及后续肾脏替代治疗方式的选择。这些医疗管理直接影响移植肾功能丧失患者的预后，但目前仍缺少相关指南或共识，往往根据临床医师的自身经验决定。本文对目前移植肾功能丧失后免疫抑制药的调整、移植肾的处理和后续肾脏替代治疗方式的选择等进行综述，旨在为延长患者的生存期和提高生活质量提供参考。
- 肾移植 /
- 移植肾功能丧失 /
- 群体反应性抗体 /
- 免疫抑制药 /
- 肾脏替代治疗 /
- 致敏 /
- 移植肾切除术 /
- 经导管血管栓塞术
Abstract: With the maturity of kidney transplantation, introduction of new immunosuppressive drugs and improvement of immunosuppressive regimen, the short-term survival rate of kidney transplant recipients has been significantly improved, whereas the long-term survival rate has not been significantly elevated. Kidney transplant recipients may have the risk of renal graft loss. Clinical management after renal graft loss is complicated, including the adjustment of immunosuppressive drugs, management of renal graft and selection of subsequent renal replacement therapy. These management procedures directly affect clinical prognosis of patients with renal graft loss. Nevertheless, relevant guidelines or consensuses are still lacking. Clinical management of patients after renal graft loss highly depend upon clinicians’ experience. In this article, the adjustment of immunosuppressive drugs, management of renal graft and selection of subsequent renal replacement therapy were reviewed, aiming to provide reference for prolonging the survival and improving the quality of life of these patients.
- Kidney transplantation /
- Renal graft loss /
- Panel reactive antibody /
- Immunosuppressive drugs /
- Renal replacement therapy /
- Sensitization /
- Allograft nephrectomy /
- Transcatheter vascular embolization

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参考文献(65)

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