张淑宇, 李月红. 非HLA抗体相关肾移植排斥反应的研究进展[J]. 器官移植, 2023, 14(5): 730-735. DOI: 10.3969/j.issn.1674-7445.2023101
引用本文: 张淑宇, 李月红. 非HLA抗体相关肾移植排斥反应的研究进展[J]. 器官移植, 2023, 14(5): 730-735. DOI: 10.3969/j.issn.1674-7445.2023101
Zhang Shuyu, Li Yuehong. Research progress on kidney transplantation rejection associated with non-HLA antibody[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 730-735. DOI: 10.3969/j.issn.1674-7445.2023101
Citation: Zhang Shuyu, Li Yuehong. Research progress on kidney transplantation rejection associated with non-HLA antibody[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 730-735. DOI: 10.3969/j.issn.1674-7445.2023101

非HLA抗体相关肾移植排斥反应的研究进展

Research progress on kidney transplantation rejection associated with non-HLA antibody

  • 摘要: 人类白细胞抗原(HLA)是由HLA基因复合体所编码的产物,定位于6号染色体短臂上,是异体免疫的主要靶点,但HLA抗体阳性并不能解释所有的肾移植排斥反应。非HLA抗体是同种异体肾移植中供者基因表达的产物,术中缺血-再灌注损伤、异体和自身免疫相互作用、细胞外囊泡的介导作用等都可以触发免疫系统反应,促使非HLA抗体产生。多项研究表明非HLA抗体是诱发排斥反应、影响肾移植结局的重要因素。因此,本文就肾移植非HLA抗体类型及形成机制进行综述,总结非HLA抗体相关肾移植排斥反应的研究进展,以期为肾移植术后非HLA抗体相关排斥反应的研究提供参考。

     

    Abstract: Human leukocyte antigen (HLA) is a product encoded by HLA gene complex, which is located on the short arm of chromosome 6 and is the main target of alloimmunity. However, positive HLA antibody is not responsible for all kinds of rejections in kidney transplantation. Non-HLA antibody is the product of donor gene expression in allogeneic kidney transplantation. Intraoperative ischemia-reperfusion injury, the interaction between alloimmunity and autoimmunity and the mediation of extracellular vesicles may trigger immune system response and promote the production of non-HLA antibody. Multiple studies have demonstrated that non-HLA antibody is an important factor of inducing rejection and affecting the outcomes of kidney transplantation. Consequently, the types and formation mechanism of non-HLA antibody in kidney transplantation were reviewed, and research progress on kidney transplantation rejection associated with non-HLA antibody was summarized, aiming to provide reference for in-depth study of kidney transplantation rejection associated with non-HLA antibody.

     

/

返回文章
返回