干细胞移植治疗睾丸衰老的现状与思考

莫嘉辉; 李欣禹; 陈志宏; 张敏; 邓春华

doi:10.3969/j.issn.1674-7445.2023.03.001

干细胞移植治疗睾丸衰老的现状与思考

doi: 10.3969/j.issn.1674-7445.2023.03.001

510080 广州，中山大学附属第一医院泌尿外科与男科(莫嘉辉、李欣禹、陈志宏、邓春华)，转化医学研究中心(张敏)

基金项目:

国家自然科学基金面上项目 81971314

国家自然科学基金面上项目 82171564

广东省自然科学基金面上项目 2023A1515010286

详细信息

作者简介:

通讯作者:
邓春华(ORCID：0009-0002-3512-4057)，Email：dengchh@mail.sysu.edu.cn

中图分类号: R329.2, R691.5
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出版历程
- 收稿日期: 2023-02-20
- 刊出日期: 2023-05-15

Current status and reflections on stem cell transplantation in the treatment of testicular aging

Department of Urology and Andrology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

More Information

Corresponding author: Deng Chunhua, Email: dengchh@mail.sysu.edu.cn

摘要

摘要: 睾丸衰老的主要特点为睾酮合成能力以及生精功能逐渐下降，不仅会影响男性生育力，也与衰老相关慢性疾病关系密切。因此，延缓睾丸衰老对于改善中老年男性健康和生活质量至关重要。干细胞是具有强大的自我更新能力和多向分化潜能的细胞群体，近年来，其基础与临床应用研究不断深化，推动了细胞疗法的发展。干细胞移植目前已被用于治疗多种疾病，在衰老与再生医学领域也受到广泛关注。干细胞移植在治疗睾丸衰老中也具有巨大的应用前景。本文将回顾干细胞移植治疗睾丸衰老的相关研究历程与进展，并探讨临床转化面临的瓶颈以及疗效优化策略，以期为睾丸衰老的干细胞疗法研发及临床转化提供新思路。
- 干细胞移植 /
- 睾丸衰老 /
- 睾丸间质干细胞 /
- 精原干细胞 /
- 间充质干细胞 /
- 诱导多能干细胞 /
- 睾酮
Abstract: Testicular aging is mainly characterized by a gradual decline in the capability of testosterone synthesis and spermatogenesis, which not only affects male fertility, but also correlates with aging-related chronic diseases intimately. Therefore, delaying testicular aging plays a significant role in improving the health and quality of life of middle-aged and elderly men. Stem cells are a cell group with potent self-renewal capability and multi-directional differentiation potential. In recent years, the research of stem cells in basic and clinical application has been carried out in-depth, which has accelerated the development of cell therapy. Currently, stem cell transplantation has been employed to treat multiple diseases, which has captivated widespread attention in the field of aging and regenerative medicine. Stem cell transplantation has demonstrated promising prospects in the treatment of testicular aging. In this article, research profile and progress of stem cell transplantation in the treatment of testicular aging were reviewed, and bottleneck issues encountered in clinical translation and strategies for optimizing clinical efficacy were discussed, aiming to provide novel ideas for the research and development and clinical translation of stem cell therapy for testicular aging.
- Stem cell transplantation /
- Testicular aging /
- Stem Leydig cell /
- Spermatogonial stem cell /
- Mesenchymal stem cell /
- Induced pluripotent stem cell /
- Testosterone

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图 1 干细胞移植研究历程的重要进展

Figure 1. The major scientific advances during the history of stem cell transplantation research

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表 1 睾丸衰老的内分泌及抗氧化治疗策略

Table 1. Strategies of endocrinotherapy and antioxidant treatment for testicular aging

治疗策略	治疗方法	研究对象
内分泌调节	补充雄激素(睾酮)	人
内分泌调节	补充睾酮+5α还原酶抑制剂	人
内分泌调节	补充促性腺激素及其类似物	人
内分泌调节	补充睾酮前体物质(脱氢表雄酮等)	人
内分泌调节	补充非芳香化雄激素	人
内分泌调节	使用雌激素拮抗剂	人
内分泌调节	补充选择性雄激素受体调节剂	人
抗氧化疗法	补充黄芪端粒酶激活剂-65	大鼠
抗氧化疗法	补充维生素D₃	大鼠
抗氧化疗法	中医药治疗(八子补肾方)	小鼠
抗氧化疗法	补充外源性脂联素	小鼠

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