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干细胞移植治疗睾丸衰老的现状与思考

莫嘉辉, 李欣禹, 陈志宏, 等. 干细胞移植治疗睾丸衰老的现状与思考[J]. 器官移植, 2023, 14(3): 319-326. doi: 10.3969/j.issn.1674-7445.2023.03.001
引用本文: 莫嘉辉, 李欣禹, 陈志宏, 等. 干细胞移植治疗睾丸衰老的现状与思考[J]. 器官移植, 2023, 14(3): 319-326. doi: 10.3969/j.issn.1674-7445.2023.03.001
Mo Jiahui, Li Xinyu, Chen Zhihong, et al. Current status and reflections on stem cell transplantation in the treatment of testicular aging[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 319-326. doi: 10.3969/j.issn.1674-7445.2023.03.001
Citation: Mo Jiahui, Li Xinyu, Chen Zhihong, et al. Current status and reflections on stem cell transplantation in the treatment of testicular aging[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 319-326. doi: 10.3969/j.issn.1674-7445.2023.03.001

干细胞移植治疗睾丸衰老的现状与思考

doi: 10.3969/j.issn.1674-7445.2023.03.001
基金项目: 

国家自然科学基金面上项目 81971314

国家自然科学基金面上项目 82171564

广东省自然科学基金面上项目 2023A1515010286

详细信息
    作者简介:
    通讯作者:

    邓春华(ORCID:0009-0002-3512-4057),Email:dengchh@mail.sysu.edu.cn

  • 中图分类号: R329.2, R691.5

Current status and reflections on stem cell transplantation in the treatment of testicular aging

More Information
  • 摘要: 睾丸衰老的主要特点为睾酮合成能力以及生精功能逐渐下降,不仅会影响男性生育力,也与衰老相关慢性疾病关系密切。因此,延缓睾丸衰老对于改善中老年男性健康和生活质量至关重要。干细胞是具有强大的自我更新能力和多向分化潜能的细胞群体,近年来,其基础与临床应用研究不断深化,推动了细胞疗法的发展。干细胞移植目前已被用于治疗多种疾病,在衰老与再生医学领域也受到广泛关注。干细胞移植在治疗睾丸衰老中也具有巨大的应用前景。本文将回顾干细胞移植治疗睾丸衰老的相关研究历程与进展,并探讨临床转化面临的瓶颈以及疗效优化策略,以期为睾丸衰老的干细胞疗法研发及临床转化提供新思路。

     

  • 图  1  干细胞移植研究历程的重要进展

    Figure  1.  The major scientific advances during the history of stem cell transplantation research

    表  1  睾丸衰老的内分泌及抗氧化治疗策略

    Table  1.   Strategies of endocrinotherapy and antioxidant treatment for testicular aging

    治疗策略 治疗方法 研究对象
    内分泌调节 补充雄激素(睾酮)
    内分泌调节 补充睾酮+5α还原酶抑制剂
    内分泌调节 补充促性腺激素及其类似物
    内分泌调节 补充睾酮前体物质(脱氢表雄酮等)
    内分泌调节 补充非芳香化雄激素
    内分泌调节 使用雌激素拮抗剂
    内分泌调节 补充选择性雄激素受体调节剂
    抗氧化疗法 补充黄芪端粒酶激活剂-65 大鼠
    抗氧化疗法 补充维生素D3 大鼠
    抗氧化疗法 中医药治疗(八子补肾方) 小鼠
    抗氧化疗法 补充外源性脂联素 小鼠
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  • 收稿日期:  2023-02-20
  • 刊出日期:  2023-05-15

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