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维生素D3在移植免疫中的应用进展

夏征, 周林. 维生素D3在移植免疫中的应用进展[J]. 器官移植, 2023, 14(2): 313-318. doi: 10.3969/j.issn.1674-7445.2023.02.020
引用本文: 夏征, 周林. 维生素D3在移植免疫中的应用进展[J]. 器官移植, 2023, 14(2): 313-318. doi: 10.3969/j.issn.1674-7445.2023.02.020
Xia Zheng, Zhou Lin. Application progress in the role of vitamin D3 in transplantation immunity[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 313-318. doi: 10.3969/j.issn.1674-7445.2023.02.020
Citation: Xia Zheng, Zhou Lin. Application progress in the role of vitamin D3 in transplantation immunity[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 313-318. doi: 10.3969/j.issn.1674-7445.2023.02.020

维生素D3在移植免疫中的应用进展

doi: 10.3969/j.issn.1674-7445.2023.02.020
基金项目: 

北京市自然科学基金 7212042

详细信息
    作者简介:
    通讯作者:

    周林,博士,副主任医师,研究方向为移植免疫耐受临床与基础研究,E-mail: commander_fmmu@126.com

  • 中图分类号: R617, R392.4

Application progress in the role of vitamin D3 in transplantation immunity

More Information
  • 摘要: 维生素D3是维持人体正常生理功能的重要维生素,其代谢物及类似物具有强大的抗炎活性。维生素D3可在人体内活化转化为类固醇激素1α,25-二羟维生素D3,而1α,25-二羟维生素D3可以激活转录因子维生素D受体,参与细胞代谢的调控,发挥免疫调节作用,这对维持机体生理健康至关重要。目前,越来越多的研究认为1α,25-二羟维生素D3在器官移植免疫调节及耐受中具有重要作用。因此,本文就1α,25-二羟维生素D3的概述及生理作用、维生素D3的免疫调节作用及维生素D3在临床器官移植中的应用进行综述,总结维生素D3在诱导移植免疫耐受中的应用价值,以期为促进维生素D3在移植免疫中的应用提供参考。

     

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出版历程
  • 收稿日期:  2022-09-27
  • 网络出版日期:  2023-03-15
  • 刊出日期:  2023-03-15

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