肾移植术后腹泻的管理

王於尘; 苗芸

doi:10.3969/j.issn.1674-7445.2023.02.007

肾移植术后腹泻的管理

doi: 10.3969/j.issn.1674-7445.2023.02.007

王於尘,
苗芸^,

510515 广州，南方医科大学南方医院器官移植科

基金项目:

国家自然科学基金 82270784

国家自然科学基金 82070770

广东省基础与应用基础研究基金 2023A1515012276

详细信息

作者简介:

通讯作者:
苗芸，Email: miaoyunecho@126.com

中图分类号: R617, R442.2
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- 被引次数: 0
出版历程
- 收稿日期: 2022-11-01
- 网络出版日期: 2023-03-15
- 刊出日期: 2023-03-15

Management of diarrhea after kidney transplantation

Wang Yuchen,
Miao Yun^,

Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

More Information

Corresponding author: Miao Yun, Email: miaoyunecho@126.com

摘要

摘要: 腹泻是肾移植术后常见的并发症，是多种移植术后高发疾病的共同临床表现。肾移植术后腹泻的常见病因包括免疫抑制药的不良反应、感染性疾病、术后新发炎症性肠病等。腹泻可严重影响肾移植受者的生活质量，并可能导致移植物失功甚至受者死亡等不良结局。由于肾移植术后腹泻的病因复杂甚至可能互相叠加，以及受者个体差异性大，肾移植术后腹泻的病因诊断和针对性治疗应遵循逐步和分阶段的原则。本文通过总结肾移植术后腹泻的流行病学与危害、常见病因及管理策略，旨在提高临床医师对肾移植术后腹泻的认识和诊疗水平，改善肾移植受者的生活质量及预后。
- 腹泻 /
- 肾移植 /
- 免疫抑制药 /
- 不良反应 /
- 艰难梭菌 /
- 诺如病毒 /
- 巨细胞病毒 /
- 炎症性肠病
Abstract: Diarrhea is a frequent complication after kidney transplantation, which is a common clinical manifestation of prevalent diseases following multiple types of organ transplantation. The common causes of diarrhea after kidney transplantation include adverse reactions of immunosuppressants, infectious diseases and de novo postoperative inflammatory bowel disease, etc. Diarrhea could seriously affect the quality of life of kidney transplant recipients, and may lead to allograft dysfunction or even death of recipients. Because the causes of diarrhea after kidney transplantation are complicated and probably overlap with each other, along with individual differences among recipients, the etiological diagnosis and targeted treatment of diarrhea after kidney transplantation should follow the principles of gradual and phased treatment. In this article, the epidemiology and harm, common causes and management strategies of diarrhea after kidney transplantation were summarized, aiming to deepen the clinicians' understanding and enhance the diagnosis and treatment levels of diarrhea after kidney transplantation, thereby improving the quality of life and prognosis of kidney transplant recipients.
- Diarrhoea /
- Kidney transplantation /
- Immunosuppresant /
- Adverse reaction /
- Clostridium difficile /
- Norovirus /
- Cytomegalovirus /
- Inflammatory bowel disease

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图 1 肾移植术后腹泻的逐步分阶段诊疗策略

Figure 1. Gradual and phased strategy on the diagnosis and treatment of diarrhea after kidney transplantation

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