移植供肺的保存与功能维护

胡春晓; 邵景博; 赵晋; 陈静瑜

doi:10.3969/j.issn.1674-7445.2023.02.006

移植供肺的保存与功能维护

doi: 10.3969/j.issn.1674-7445.2023.02.006

214023 无锡，南京医科大学附属无锡人民医院江苏省肺移植中心无锡市器官移植研究院（胡春晓、邵景博、赵晋、陈静瑜）；南京医科大学附属无锡人民医院移植麻醉科（胡春晓）

基金项目:

国家自然科学基金 82070059

江苏省科技计划重点研究项目 BE2022697

无锡市太湖人才计划国际国内顶尖医学专家团队 2019-THRCTD-1

详细信息

作者简介:

通讯作者:
胡春晓，Email：huchunxiao91211@163.com

陈静瑜，Email：chenjy@wuxiph.com

中图分类号: R617, R563
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- 文章访问数: 418
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- PDF下载量: 81
- 被引次数: 0
出版历程
- 收稿日期: 2022-12-27
- 网络出版日期: 2023-03-15
- 刊出日期: 2023-03-15

Preservation and functional maintenance of lung allograft

The Affiliated Wuxi People's Hospital of Nanjing Medical University, Jiangsu Lung Transplant Center, Wuxi Lung Transplant Center, Wuxi 214023, China

More Information

Corresponding author: Hu Chunxiao, Email: huchunxiao91211@163.com; Chen Jingyu, Email: chenjy@wuxiph.com

摘要

摘要: 肺移植作为终末期肺病最后的治疗手段，不仅可以明显延长患者的生存时间，还能很大程度改善患者的生活质量。在过去的几十年里，随着外科技术、免疫抑制药和移植术后管理方面的进步，全球肺移植手术量激增。但供肺短缺极大限制了肺移植的发展，需要开发创新方法来扩大供者库。捐献者数量以及潜在供肺的有效保存与功能维护是扩大供者库的关键，供肺质量是保证肺移植受者术后长期生存的重要前提，移植肺的保存与功能维护在保证供肺质量方面尤为重要。本文总结了获取前供肺的管理与维护、供肺获取及移植肺的保存与功能维护的最新进展，以期为临床肺移植的发展提供参考。
- 肺移植 /
- 供肺保存 /
- 功能维护 /
- 原发性移植物功能障碍 /
- 离体肺灌注 /
- 机械通气 /
- 液体管理 /
- 激素
Abstract: As the final resolution for end-stage lung disease, lung transplantation can not only significantly prolong the survival, but also remarkably improve the quality of life of recipients. In recent decades, with the advancement of surgical techniques, immunosuppressants and post-transplantation management, the quantity of lung transplantation has been surged around the globe. However, the shortage of donor lung has severely restricted the development of lung transplantation. It is necessary to develop innovative approaches to expand the donor pool. The number of donors and effective preservation and functional maintenance of potential donor lungs play a key role in expanding the donor pool. The quality of donor lung is a critical precondition to ensure the long-term survival of lung transplant recipients. Preservation and functional maintenance of donor lung are of significance for guaranteeing the quality of lung allograft. In this article, research progresses on the management and maintenance of donor lung before procurement, the procurement of donor lung and the preservation and functional maintenance of lung allograft were reviewed, aiming to provide reference for the development of lung transplantation in clinical practice.
- Lung transplantation /
- Donor lung preservation /
- Functional maintenance /
- Primary graft dysfunction /
- Ex vivo lung perfusion /
- Mechanical ventilation /
- Fluid management /
- Hormone

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参考文献(47)

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