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摘要: 免疫耐受的诱导是器官移植免疫领域的重要组成部分和最高追求目标,它基于对移植抗原识别、提呈以及免疫系统的激活和应答等免疫学本质的认识。但是,在成功诱导免疫耐受之前,如何对器官移植受者实施个体化免疫耐受诱导,从而使免疫抑制剂和个体化治疗措施实现最优化的搭配,来达到预防和治疗排斥反应的效果最佳、不良反应最小的理想状态,仍然是移植工作者不断探索和仍未解决的难题。本文综合国际核心期刊报道内容,从免疫耐受诱导机制、可操作性免疫耐受的实现、个体化免疫耐受诱导新策略及调节性T细胞在个体化免疫耐受中的应用,并结合本中心调节性T细胞临床和基础研究成果综合讨论个体化免疫耐受诱导策略和未来展望。Abstract: The induction of immune tolerance is an essential component and the utmost goal in the field of organ transplantation immunity, which depends upon the recognition and presentation of transplantation antigens, the activation and response of the immune system and other immune essence. However, before successfully inducing immune tolerance, how to carry out individualized induction of immune tolerance in organ transplant recipients to optimize the combination of immunosuppressive agents and individualized treatment and achieve the ideal state of optimal prevention and treatment of immune rejection and minimal adverse reactions, remains to be further resolved by the organ transplantation practitioners. Based on the reports of international core journals, the individualized induction strategy of immune tolerance and the future prospects were reviewed in this article from the following aspects including the mechanism underlying induction of immune tolerance, realization of operational immune tolerance, novel strategy of individualized induction of immune tolerance and application of regulatory T cell in individualized immune tolerance in combination with clinical and laboratory research results of regulatory T cell in our center.
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