Abstract: Effective preoperative matching of organ transplantation is essential for the success of organ transplantation. The current methods of preoperative matching for xenotransplantation are derived from human allogeneic organ transplantation. However, these methods are simple and cannot accurately predict whether rejection will occur after transplantation. The multi-link and multi-dimensional preoperative matching is conducive to accurately screening suitable donors and reducing the occurrence of postoperative rejection after xenotransplantation, including making full use of the advantages of donor control in xenotransplantation, expanding tissue level matching methods on the basis of improving traditional cytological matching, paying attention to the role of endothelial cells in matching, and developing organic-level matching methods. Therefore, this article reviews the methods of allogeneic organ transplantation matching, current methods, existing problem, and possible breakthroughs of xenotransplantation matching, in order to provide reference for further research on xenotransplantation matching.