Research progress on the role of tolerogenic dendritic cells in immune tolerance of liver transplantation
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摘要: 肝移植术后排斥反应严重影响受者生存，长期应用免疫抑制药是预防排斥反应的重要手段，但其存在毒性作用，以及会增加全身感染、肿瘤复发等不良事件的风险。因此，在成功肝移植手术之前，如何对受者实施个体化免疫耐受诱导，实现术后免疫抑制药完全或早期撤退，仍然是器官移植工作者不断探索的研究方向。近年来，耐受性树突状细胞诱导肝移植免疫耐受的机制研究取得了一些新的进展，临床试验初显成效。本文就耐受性树突状细胞的特征、参与重塑肝脏免疫微环境的机制及其诱导肝移植免疫耐受基础研究与临床应用进展进行综述，以期为耐受性树突状细胞在肝移植免疫耐受中的应用研究提供参考。Abstract: Rejection after liver transplantation severely affects the survival of recipients. Long-term use of immunosuppressants is an important approach to prevent rejection, whereas it may cause toxic effects and increase the risk of adverse events such as systemic infection and tumor recurrence, etc. Therefore, before successful liver transplantation, how to induce individual immune tolerance of recipients and achieve complete or early withdrawal of postoperative immunosuppressants remains to be investigated by practitioners of organ transplantation. In recent years, certain progresses have been made in the mechanism of immune tolerance induced by tolerogenic dendritic cells in liver transplantation, and preliminary outcomes have been obtained in clinical trials. In this article, basic research and clinical application progress in the characteristics of tolerogenic dendritic cells, the mechanism underlying participating in liver immune microenvironment remodeling, and inducing immune tolerance in liver transplantation were reviewed, aiming to provide reference for the application of tolerogenic dendritic cells in immune tolerance of liver transplantation.
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