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间充质干细胞在1型糖尿病胰岛移植中的应用进展

朱淑芳, 牟丽莎. 间充质干细胞在1型糖尿病胰岛移植中的应用进展[J]. 器官移植, 2024, 15(2): 214-219. doi: 10.3969/j.issn.1674-7445.2023194
引用本文: 朱淑芳, 牟丽莎. 间充质干细胞在1型糖尿病胰岛移植中的应用进展[J]. 器官移植, 2024, 15(2): 214-219. doi: 10.3969/j.issn.1674-7445.2023194
Zhu Shufang, Mou Lisha. Application progress of mesenchymal stem cells in islet transplantation for type 1 diabetes mellitus[J]. ORGAN TRANSPLANTATION, 2024, 15(2): 214-219. doi: 10.3969/j.issn.1674-7445.2023194
Citation: Zhu Shufang, Mou Lisha. Application progress of mesenchymal stem cells in islet transplantation for type 1 diabetes mellitus[J]. ORGAN TRANSPLANTATION, 2024, 15(2): 214-219. doi: 10.3969/j.issn.1674-7445.2023194

间充质干细胞在1型糖尿病胰岛移植中的应用进展

doi: 10.3969/j.issn.1674-7445.2023194
基金项目: 国家重点研发计划(2017YFC1103704);深圳市科技计划(GJHZ20200731095207021)
详细信息
    作者简介:
    通讯作者:

    牟丽莎(ORCID 0000-0001-6232-8341),Email:lishamou@gmail.com

  • 中图分类号: R617, R587.1

Application progress of mesenchymal stem cells in islet transplantation for type 1 diabetes mellitus

More Information
  • 摘要: 胰岛移植被认为是治疗1型糖尿病的有效方法之一,但其疗效受到多种因素限制。胰岛在分离、培养和移植过程中的缺氧、应激及排斥反应,都会影响胰岛移植的结局。间充质干细胞(MSC)因其抗炎、促进血管生成和调节免疫代谢等生物特性,一直备受研究者关注。此外,MSC的衍生物如外泌体在调节缺氧诱导的氧化应激、促进机体血管形成和调节免疫方面也具有重要作用。基于MSC的胰岛移植可能是1型糖尿病的有效治疗方法。因此,本文就MSC在胰岛移植前后发挥的潜在作用进行综述,并探讨其临床应用及局限性,以期为今后胰岛移植治疗1型糖尿病的相关研究提供新的思路和见解。

     

  • FIG. 2991.  FIG. 2991.

    FIG. 2991..  FIG. 2991.

    表  1  胰岛与MSC联合移植的途径及功能

    Table  1.   Pathways and functions of combined islet and MSC transplantation

    移植途径 侵入性 感染率 机制 功能
    胰腺内途径 改善直接接触和共同移植 保护胰岛
    静脉途径 较高 间接接触,体液因子 保护胰岛
    皮下途径 较低 间接接触,体液因子 通过包裹以防止排斥反应
    肾包膜途径 改变细胞因子产生模式 创造免疫生态位
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  • 收稿日期:  2023-10-03
  • 网络出版日期:  2023-12-26
  • 刊出日期:  2024-03-15

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