巨噬细胞转分化在肾纤维化中的调控机制

杨艳燕; 陶涛; 罗朋立

doi:10.3969/j.issn.1674-7445.2023190

巨噬细胞转分化在肾纤维化中的调控机制

doi: 10.3969/j.issn.1674-7445.2023190

杨艳燕^{1, 2,},
陶涛^{1, 3},
罗朋立^2, ,

1.
810001　西宁，青海大学高原医学研究中心高原医学教育部重点实验室青海省高原医学应用基础重点实验室（青海-犹他高原医学联合重点实验室）
2.
青海大学附属医院肾内科青海省慢性肾病临床医学研究中心
3.
泌尿外科

基金项目: 青海省科技计划应用基础研究（2022-ZJ-766）

详细信息

作者简介:

通讯作者:
罗朋立（ORCID 0009-0008-2271-2750），博士，教授，主任医师，研究方向为低氧与肾脏病，Email：qhlpl2108@163.com

中图分类号: R617, R329.2
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出版历程
- 收稿日期: 2023-09-26
- 网络出版日期: 2023-11-29
- 刊出日期: 2024-01-11

Regulation mechanism of macrophage transition in renal fibrosis

Yang Yanyan^{1, 2
,},
Tao Tao^{1, 3},
Luo Pengli^{2
, ,}

1.
Research Center for High Altitude Medicine, Qinghai University, Key Laboratory of High Altitude Medicine of Ministry of Education, Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai-Utah Joint Research Key Lab for High Altitude Medicine), Xining 810001, China

More Information

Corresponding author: Luo Pengli, Email: qhlpl2108@163.com

摘要

摘要: 肾纤维化是所有进展性慢性肾病发展至终末期肾病的共同病理改变。肾移植术后发生肾纤维化会严重影响移植肾功能。巨噬细胞具有高度的异质性和可塑性，在肾损伤过程中，受局部微环境刺激被募集、激活和极化，通过多种机制参与肾组织损伤、修复和纤维化的过程。近年来，多项研究表明，巨噬细胞可以转分化为肌成纤维细胞直接参与肾纤维化形成，这一过程被称为巨噬细胞-肌成纤维细胞转分化，但其调控机制尚不清楚。因此，本文就巨噬细胞在肾纤维化中的作用、巨噬细胞-肌成纤维细胞转分化的特点及可能的调控机制进行综述，以期为肾纤维化的相关研究提供参考。
- 肾纤维化 /
- 巨噬细胞 /
- 肌成纤维细胞 /
- 肾移植 /
- 慢性肾病 /
- 终末期肾病 /
- 转化生长因子 /
- Smad3
Abstract: Renal fibrosis is a common pathological change from development to end-stage renal diseases in all progressive chronic kidney diseases. Renal fibrosis after kidney transplantation will severely affect the renal graft function. Macrophages are characterized with high heterogeneity and plasticity. During the process of kidney injury, macrophages are recruited, activated and polarized by local microenvironment, and participate in the process of renal tissue injury, repair and fibrosis through multiple mechanisms. Recent studies have shown that macrophages may transit into myofibroblasts and directly participate in the formation of renal fibrosis. This process is known as macrophage-myofibroblast transition. Nevertheless, the regulatory mechanism remains elusive. In this article, the role of macrophages in renal fibrosis, the characteristics of macrophage-myofibroblast transition and the possible regulatory mechanism were reviewed, aiming to provide reference for relevant research of renal fibrosis.
- Renal fibrosis /
- Macrophage /
- Myofibroblast /
- Kidney transplantation /
- Chronic kidney disease /
- End-stage renal disease /
- Transforming growth factor /
- Smad3

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