杨昊, 林俊, 张健. 移植肾功能丧失受者的临床管理策略[J]. 器官移植, 2024, 15(1): 138-144. DOI: 10.3969/j.issn.1674-7445.2023149
引用本文: 杨昊, 林俊, 张健. 移植肾功能丧失受者的临床管理策略[J]. 器官移植, 2024, 15(1): 138-144. DOI: 10.3969/j.issn.1674-7445.2023149
Yang Hao, Lin Jun, Zhang Jian. Clinical management strategies for recipients with renal graft loss[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 138-144. DOI: 10.3969/j.issn.1674-7445.2023149
Citation: Yang Hao, Lin Jun, Zhang Jian. Clinical management strategies for recipients with renal graft loss[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 138-144. DOI: 10.3969/j.issn.1674-7445.2023149

移植肾功能丧失受者的临床管理策略

Clinical management strategies for recipients with renal graft loss

  • 摘要: 随着肾移植手术技术的成熟和新型免疫抑制药的引入以及免疫抑制方案的改进,肾移植受者的短期生存率已显著提高,但长期生存并未得到显著改善。肾移植受者通常可能面临移植肾功能丧失。移植肾功能丧失后的医疗管理较为复杂,包括免疫抑制药的调整、移植肾的处理以及后续肾脏替代治疗方式的选择。这些医疗管理直接影响移植肾功能丧失患者的预后,但目前仍缺少相关指南或共识,往往根据临床医师的自身经验决定。本文对目前移植肾功能丧失后免疫抑制药的调整、移植肾的处理和后续肾脏替代治疗方式的选择等进行综述,旨在为延长患者的生存期和提高生活质量提供参考。

     

    Abstract: With the maturity of kidney transplantation, introduction of new immunosuppressive drugs and improvement of immunosuppressive regimen, the short-term survival rate of kidney transplant recipients has been significantly improved, whereas the long-term survival rate has not been significantly elevated. Kidney transplant recipients may have the risk of renal graft loss. Clinical management after renal graft loss is complicated, including the adjustment of immunosuppressive drugs, management of renal graft and selection of subsequent renal replacement therapy. These management procedures directly affect clinical prognosis of patients with renal graft loss. Nevertheless, relevant guidelines or consensuses are still lacking. Clinical management of patients after renal graft loss highly depend upon clinicians’ experience. In this article, the adjustment of immunosuppressive drugs, management of renal graft and selection of subsequent renal replacement therapy were reviewed, aiming to provide reference for prolonging the survival and improving the quality of life of these patients.

     

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