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铁死亡在器官移植缺血-再灌注损伤中的作用与展望

李佳蔚, 许红阳. 铁死亡在器官移植缺血-再灌注损伤中的作用与展望[J]. 器官移植, 2023, 14(5): 662-668. doi: 10.3969/j.issn.1674-7445.2023058
引用本文: 李佳蔚, 许红阳. 铁死亡在器官移植缺血-再灌注损伤中的作用与展望[J]. 器官移植, 2023, 14(5): 662-668. doi: 10.3969/j.issn.1674-7445.2023058
Li Jiawei, Xu Hongyang. Role and prospect of ferroptosis in ischemia-reperfusion injury during organ transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 662-668. doi: 10.3969/j.issn.1674-7445.2023058
Citation: Li Jiawei, Xu Hongyang. Role and prospect of ferroptosis in ischemia-reperfusion injury during organ transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 662-668. doi: 10.3969/j.issn.1674-7445.2023058

铁死亡在器官移植缺血-再灌注损伤中的作用与展望

doi: 10.3969/j.issn.1674-7445.2023058
基金项目: 国家自然科学基金(82070059)
详细信息
    作者简介:
    通讯作者:

    许红阳(ORCID:0009-0003-8847-3506),医学博士,主任医师,研究方向为重症医学及肺移植术后监护,Email:xhy1912@aliyun.com

  • 中图分类号: R617, R329.2

Role and prospect of ferroptosis in ischemia-reperfusion injury during organ transplantation

More Information
  • 摘要: 铁死亡是近年来新发现的一种程序性细胞死亡方式,被定义为由脂质过氧化损伤介导而引起的铁依赖性的程序性坏死。铁死亡作为一种保守性程序,在包括植物和动物界在内的各种生物的发展和疾病中起着至关重要的作用。自从2012年铁死亡被首次报道以来,人们对铁死亡的过程及其在疾病治疗中的作用产生较大兴趣。缺血-再灌注损伤是一种在器官移植中常见的病理过程,而铁死亡被认为是引起缺血-再灌注损伤的重要方式之一,因此,本文就铁死亡的定义、调控机制,以及其在肾、肝、心脏、肺移植术后缺血-再灌注损伤中的作用机制等进行综述,以期为器官移植缺血-再灌注损伤的预防与治疗提供理论基础。

     

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出版历程
  • 收稿日期:  2023-04-21
  • 网络出版日期:  2023-07-20
  • 刊出日期:  2023-09-15

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