牛义善, 曾强. 炎症生物标志物对肝癌肝移植预后的预测作用[J]. 器官移植, 2022, 13(1): 49-54. DOI: 10.3969/j.issn.1674-7445.2022.01.008
引用本文: 牛义善, 曾强. 炎症生物标志物对肝癌肝移植预后的预测作用[J]. 器官移植, 2022, 13(1): 49-54. DOI: 10.3969/j.issn.1674-7445.2022.01.008
Niu Yishan, Zeng Qiang. Predictive effect of inflammatory biomarkers on prognosis of liver transplantation for hepatocellular carcinoma[J]. ORGAN TRANSPLANTATION, 2022, 13(1): 49-54. DOI: 10.3969/j.issn.1674-7445.2022.01.008
Citation: Niu Yishan, Zeng Qiang. Predictive effect of inflammatory biomarkers on prognosis of liver transplantation for hepatocellular carcinoma[J]. ORGAN TRANSPLANTATION, 2022, 13(1): 49-54. DOI: 10.3969/j.issn.1674-7445.2022.01.008

炎症生物标志物对肝癌肝移植预后的预测作用

Predictive effect of inflammatory biomarkers on prognosis of liver transplantation for hepatocellular carcinoma

  • 摘要: 肝细胞癌(肝癌)肝移植术后肿瘤复发是影响受者远期生存的主要问题。术前精确评估和合理选择移植受者是影响肝癌移植受者远期预后的关键因素。中性粒细胞、淋巴细胞、C-反应蛋白、血小板、纤维蛋白原(FIB)等是提示机体炎症反应的生物学指标,多项研究发现此类生物学指标不仅可以代表炎症反应,也可将其整合以用于预测肝癌肝移植术后肿瘤复发和受者长期生存率,这其中主要包括中性粒细胞/淋巴细胞比值(NLR)、格拉斯哥预后评分(GPS)、FIB、血小板/淋巴细胞比值(PLR)、预后营养指数(PNI)等。本文就炎症生物标志物对肝癌肝移植预后的预测作用的研究进展做一综述。

     

    Abstract: Tumor recurrence is the main issue that affects the long-term survival of recipients after liver transplantation for hepatocellular carcinoma. Accurate preoperative evaluation and proper selection of transplant recipients are the key factors affecting the long-term prognosis of recipients undergoing liver transplantation for hepatocellular carcinoma. Neutrophil, lymphocyte, C-reactive protein, platelet and fibrinogen (FIB) are major biomarkers that indicate inflammatory response of the host. Multiple studies have found that these biomarkers may not only represent the inflammatory response, but also could be integrated to predict tumor recurrence and long-term survival rate of the recipients following liver transplantation for hepatocellular carcinoma. These biomarkers mainly consist of neutrophil-to-lymphocyte ratio (NLR), Glasgow prognostic score (GPS), FIB, platelet-to-lymphocyte ratio (PLR) and prognostic nutritional index (PNI), etc. In this article, research progresses on predictive effect of inflammatory biomarkers on prognosis of liver transplantation for hepatocellular carcinoma were reviewed.

     

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