Abstract: Donor infection can be transmitted to the recipients through the grafts, leading to complications and even death. Donor-derived infection is an important cause of early infection after solid organ transplantation. The Chinese version of Guide to the Quality and Safety on Organs for Transplantation (6th edition) drafted by European Union in 2016 has been officially published. The Chapter 8 entitled 'Risk of infectious disease transmission' elaborates the medical history and behavioral history of infection risk of asymptomatic donors, basic screening highlights of various types of infections, transmission risk, prevention and control strategies of various pathogens. This chapter was mainly interpreted in this article.