李海波, 汪国营, 曾凯宁, 等. 15-PGDH表达水平与肝癌肝移植临床预后关系研究[J]. 器官移植, 2020, 11(2): 247-252, 281. DOI: 10.3969/j.issn.1674-7445.2020.02.010
引用本文: 李海波, 汪国营, 曾凯宁, 等. 15-PGDH表达水平与肝癌肝移植临床预后关系研究[J]. 器官移植, 2020, 11(2): 247-252, 281. DOI: 10.3969/j.issn.1674-7445.2020.02.010
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Li Haibo, Wang Guoying, Zeng Kaining, et al. Relationship between expression level of 15-PGDH and clinical prognosis of liver transplantation for hepatocellular carcinoma[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 247-252, 281. DOI: 10.3969/j.issn.1674-7445.2020.02.010
Citation: Li Haibo, Wang Guoying, Zeng Kaining, et al. Relationship between expression level of 15-PGDH and clinical prognosis of liver transplantation for hepatocellular carcinoma[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 247-252, 281. DOI: 10.3969/j.issn.1674-7445.2020.02.010
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15-PGDH表达水平与肝癌肝移植临床预后关系研究

Relationship between expression level of 15-PGDH and clinical prognosis of liver transplantation for hepatocellular carcinoma

    摘要
  • 摘要:
      目的  探讨15-羟基前列腺素脱氢酶（15-PGDH）表达水平与肝细胞癌（肝癌）肝移植临床预后的关系。
      方法  回顾性分析行肝癌肝移植术的94例受者临床资料。用免疫组织化学法检测所有受者病理组织切片中15-PGDH表达情况；分析15-PGDH蛋白表达水平与肝癌患者各项临床参数的关系；计算肝癌肝移植受者术后5年的无瘤生存率和总生存率；分析可能影响肝癌肝移植受者预后的独立危险因素。
      结果  15-PGDH的表达水平与受者的年龄、Child-Pugh分级和术前甲胎蛋白（AFP）水平相关（均为P < 0.05）。15-PGDH低表达组受者的无瘤生存率和总生存率均显著低于15-PGDH高表达组受者（均为P < 0.05）。15-PGDH表达水平、肿瘤分化程度、美国癌症联合会（AJCC）分期是影响肝癌肝移植受者预后的独立危险因素（均为P < 0.05）。
      结论  15-PGDH表达水平是影响肝癌肝移植受者预后的独立危险因素。

     

    Abstract:
      Objective  To investigate the relationship between the expression level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and clinical prognosis of liver transplantation for hepatocellular carcinoma.
      Methods  The clinical data of 94 recipients undergoing liver transplantation for hepatocellular carcinoma were retrospectively analyzed. The expression of 15-PGDH in the pathological tissues of all recipients was detected by immunohistochemical staining. The relationship between the expression level of 15-PGDH protein and clinical parameters of hepatocellular carcinoma patients was analyzed. The 5-year tumor-free survival and overall survival rates of liver transplant recipients were calculated. The possible independent risk factors of the clinical prognosis of liver transplant recipients were analyzed.
      Results  The expression level of 15-PGDH was significantly correlated with age, Child-Pugh grade and preoperative level of alpha-fetoprotein (AFP) of the recipients (all P < 0.05). The tumor-free survival and overall survival rates of the recipients with low expression of 15-PGDH were significantly lower than those in their counterparts with high expression of 15-PGDH (both P < 0.05). The expression level of 15-PGDH, degree of tumor differentiation and American Joint Committee on Cancer (AJCC) staging were the independent risk factors of clinical prognosis of liver transplantation for hepatocellular carcinoma (all P < 0.05).
      Conclusions  The expression level of 15-PGDH is an independent risk factor of clinical prognosis of liver transplantation for hepatocellular carcinoma.

     

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