体重指数与早期移植肾功能的关系

Correlation between body mass index and early graft function

    摘要
  • 摘要:
      目的  探讨体重指数(BMI)与早期移植肾功能的关系。
      方法  回顾性研究2003年11月至2014年11月在新疆医科大学第一附属医院肾病科接受同种异体活体肾移植的133例受者的临床资料。根据移植前的BMI将受者分为3组, 消瘦组(BMI < 18.5 kg/m2)、正常体重组(BMI 18.5~23.9 kg/m2)、超重肥胖组(BMI>23.9 kg/m2)。比较3组受者术后1周的实验室指标血尿素氮(BUN)、血清肌酐(Scr)、血红蛋白、血清白蛋白、总胆固醇和甘油三酯、移植肾功能延迟恢复发生率, 并对肾移植受者Scr与BMI进行相关分析。
      结果  3组受者的Scr水平比较差异有统计学意义(P < 0.05);两两比较, 超重肥胖组Scr水平高于正常体重组, 差异有统计学意义(Z=-3.408, P=0.01)。3组肾移植受者血红蛋白、血清白蛋白、总胆固醇水平差异均无统计学意义(均为P>0.05)。肾移植受者Scr水平与BMI呈正相关(r=0.187, P=0.031), Scr水平随BMI增加而升高。
      结论  BMI影响早期移植肾功能恢复, 肾移植术前控制体重, 有助于改善移植肾功能。

     

    Abstract:
      Objective  To investigate the correlation between body mass index (BMI) and early graft function.
      Methods  Clinical data of 133 recipients underwent renal allograft transplantation in the Department of Nephropathy of the First Affiliated Hospital of Xinjiang Medical University from November 2003 to November 2014 were retrospectively studied. According to BMI before transplantation, the recipients were divided into 3 groups: emaciation group (BMI < 18.5 kg/m2), normal weight group (BMI of 18.5-23.9 kg/m2) and overweight group (BMI>23.9 kg/m2). The laboratory indexes blood urea nitrogen (BUN), serum creatinine (Scr), hemoglobin, serum albumin, total cholesterol and triglyceride and the incidence of delayed graft function at 1 week after transplantation were compared among three groups. The correlation between Scr and BMI was analyzed.
      Results  There was significant difference in Scr level among three groups(P < 0.05). In pairwise comparison, Scr level of the overweight group was higher than that of the normal weight group and the difference had statistical significance (Z=-3.408, P=0.01). The hemoglobin, serum albumin and total cholesterol of the three groups showed no difference with statistical significance (all in P>0.05). The Scr level of renal transplant recipients was positively correlated with BMI (r=0.187, P=0.031), and Scr level raised with the increase of BMI.
      Conclusions  BMI influences the recovery of early graft function. To control body weight before transplantation is beneficial to improve graft function.

     

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