肾移植受者睡眠障碍的研究进展

Research advances on sleep disorders in kidney transplant recipients

  • 摘要: 睡眠障碍在终末期肾病(ESRD)患者中具有较高的发生率,严重影响患者的生活质量。作为ESRD最有效的治疗手段,肾移植虽能显著改善患者肾功能并延长其生存期,但临床观察发现,19.3%~78.0%的肾移植受者术后仍持续存在失眠障碍、睡眠相关呼吸障碍及睡眠相关运动障碍等多种睡眠障碍。这些睡眠障碍不仅导致日间功能受损,还与心血管不良事件、感染风险增加等不良预后密切相关。目前,针对肾移植受者睡眠障碍的发生机制研究尚不充分,临床诊疗也面临诸多挑战。本文系统综述了肾移植受者睡眠障碍的流行病学特征、病理生理机制、临床影响及诊疗新进展,旨在为临床医师提供循证依据,推动建立更完善的早期筛查和个体化治疗方案,从而改善肾移植受者长期预后。

     

    Abstract: Sleep disorders have a high incidence rate in patients with end-stage renal disease (ESRD) and severely affect their quality of life. As the most effective treatment for (ESRD), kidney transplantation can significantly improve renal function and prolong survival of patients. However, clinical observations have found that 19.3% to 78.0% of kidney transplant recipients still experience persistent various sleep disorders such as insomnia, sleep-related breathing disorders and sleep-related movement disorders after surgery. These sleep disorders not only lead to impaired daytime function but are also closely related to adverse outcomes such as cardiovascular complications and increased infection risks. Currently, research on the pathogenesis of sleep disorders in kidney transplant recipients is still insufficient, and clinical diagnosis and treatment face many challenges. This article systematically reviews the epidemiological characteristics, pathophysiological mechanisms, clinical impacts, and new developments in the diagnosis and treatment of sleep disorders in kidney transplant recipients. It aims to provide evidence-based support for clinicians and promote the establishment of more comprehensive early screening and individualized treatment plans to improve the long-term prognosis of recipients.

     

/

返回文章
返回