Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers in clinical practice. Hepatectomy and liver transplantation are currently important treatment modalities for HCC. However, for patients with end-stage liver disease, liver transplantation is the optimal choice, as it can completely resect the tumor while restoring normal liver function. Nevertheless, clinical liver transplantation for HCC faces challenges such as a shortage of donor livers and a high risk of postoperative tumor recurrence and metastasis. How to select HCC patients for liver transplantation and effectively improve the prognosis of HCC liver transplantation has become a hot topic in clinical practice, involving multiple aspects from preoperative precise evaluation to long-term postoperative follow-up. Therefore, this article reviews the full-process management of HCC liver transplantation, including preoperative management, surgical management, postoperative management and the application of multidisciplinary comprehensive treatment in HCC liver transplantation, in order to provide references for improving the prognosis of HCC liver transplant recipients.