Research progress on the role of normothermic machine perfusion in the preservation of severed limbs

Jia Zhibo; Guan Yanjun; Song Xiangyu; Dong Yanghui; Yang Boyao; Cui Mengyi; Xu Wenjing; Peng Jiang

doi:10.3969/j.issn.1674-7445.2024062

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Jia Zhibo, Guan Yanjun, Song Xiangyu, et al. Research progress on the role of normothermic machine perfusion in the preservation of severed limbs[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024062

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Research progress on the role of normothermic machine perfusion in the preservation of severed limbs

doi: 10.3969/j.issn.1674-7445.2024062

Jia Zhibo^{1, 2
,},
Guan Yanjun^{1, 3},
Song Xiangyu^{1, 2},
Dong Yanghui^{1, 2},
Yang Boyao^{1, 3},
Cui Mengyi¹,
Xu Wenjing¹,
Peng Jiang^{1
,
,}

1.
Research Institute of Orthopaedic Medicine Department, the Fourth Medical Center of the Chinese People's Liberation Army, , All-Army Orthopaedic Battle Trauma Key Laboratory, Beijing Key Laboratory of Orthopaedic Regenerative Medicine, Beijing 100853, China

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Corresponding author: Peng Jiang, Email: pengjiang301@126.com
Received Date: 2024-04-20
Available Online: 2024-07-08

Abstract

Abstract

Limb dismemberment injuries are common in clinical practice, and safe and effective protection of the dismembered limb is the key to successful limb replantation. Normothermic machine perfusion has made significant breakthrough in the field of organ transplantation, which may maintain the active function of organs and tissues for a long period of time and prolong the preservation time. These findings have been validated in large animal models and clinical trials. Meantime, this technology is expected to provide novel reference for the preservation and functional recovery of severed limbs. Therefore, this paper reviews the problems of static cold preservation in the preservation of disarticulated limbs, the development history of mechanical perfusion, the current status of clinical application of ambient mechanical perfusion of disarticulated limbs as well as the problems to be solved, and looks forward to the direction of its development and the prospect of its clinical application, with a view to promoting the wide application of this technology in the clinic.
- Severed limb,
- Limb preservation,
- Static cold storage,
- Normothermic machine perfusion,
- Limb replantation,
- Ischemia-reperfusion injury,
- Perfusion fluid,
- Oxygen containing carrier

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References(46)

References

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Research progress on the role of normothermic machine perfusion in the preservation of severed limbs

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Research progress on the role of normothermic machine perfusion in the preservation of severed limbs

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