Effect of preoperative metabolic syndrome on early function of renal allografts in kidney transplant recipients

Tang Yongbin; Tian Zijian; Zhang Zhipeng; Wang Jinfu; Liu Ming; Zhang Yaqun

doi:10.3969/j.issn.1674-7445.2024045

Volume 15 Issue 4

Jul. 2024

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Article Navigation > ORGAN TRANSPLANTATION > 2024 > 15(4): 607-613

Tang Yongbin, Tian Zijian, Zhang Zhipeng, et al. Effect of preoperative metabolic syndrome on early function of renal allografts in kidney transplant recipients[J]. ORGAN TRANSPLANTATION, 2024, 15(4): 607-613. doi: 10.3969/j.issn.1674-7445.2024045

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Effect of preoperative metabolic syndrome on early function of renal allografts in kidney transplant recipients

doi: 10.3969/j.issn.1674-7445.2024045

Tang Yongbin^{1, 2
,},
Tian Zijian³,
Zhang Zhipeng¹,
Wang Jinfu¹,
Liu Ming^{1, 2},
Zhang Yaqun^{3
,
,}

1.
Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China

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Corresponding author: Zhang Yaqun, Email: zhangyqbjyy@126.com
Received Date: 2024-02-18
Available Online: 2024-04-28
Publish Date: 2024-07-15

Abstract

Abstract

Objective To evaluate the effect of preoperative metabolic syndrome on early function of renal allografts in allogeneic kidney transplant recipients. Methods Clinical data of 117 kidney transplant recipients were retrospectively analyzed. According to the renal allograft function, they were divided into the delayed graft function (DGF) group (n=29) and non-DGF group (n=88). Relevant risk factors of DGF in recipients undergoing allogeneic kidney transplantation were assessed by univariate and multivariate regression analyses. The effect of preoperative metabolic syndrome on early function of renal allografts was analyzed. Results Among 117 kidney transplant recipients, 47 cases were complicated with preoperative metabolic syndrome, and 29 cases developed postoperative DGF. In the DGF group, 83% of the recipients were complicated with preoperative metabolic syndrome, higher than 74% in the non-DGF group (P<0.05). Univariate analysis showed that the body mass index (BMI) and terminal serum creatinine (Scr) level of the donors, and BMI, blood glucose level, triglyceride level and the proportion of preoperative metabolic syndrome of the recipients in the DGF group were higher than those in the non-DGF group (all P<0.05). Multivariate logistic regression analysis revealed that high Scr levels of the donors, high hemoglobin levels of the recipients and preoperative metabolic syndrome of the recipients were the independent risk factors for DGF after kidney transplantation (all P<0.05). Conclusions Preoperative metabolic syndrome is an independent risk factor for DGF in allogeneic kidney transplant recipients. Corresponding measures should be taken to lower the incidence of DGF and other metabolic complications.
- Kidney transplantation,
- Metabolic syndrome,
- Obesity,
- Blood glucose,
- Blood lipid,
- Delayed graft function,
- Serum creatinine,
- Estimated glomerular filtration rate

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References(38)

References

[1]	AZEGAMI T, KOUNOUE N, SOFUE T, et al. Efficacy of pre-emptive kidney transplantation for adults with end-stage kidney disease: a systematic review and meta-analysis[J]. Ren Fail, 2023, 45(1): 2169618. DOI: 10.1080/0886022X.2023.2169618.
[2]	STROHMAIER S, WALLISCH C, KAMMER M, et al. Survival benefit of first single-organ deceased donor kidney transplantation compared with long-term dialysis across ages in transplant-eligible patients with kidney failure[J]. JAMA Netw Open, 2022, 5(10): e2234971. DOI: 10.1001/jamanetworkopen.2022.34971.
[3]	JAHN L, RÜSTER C, SCHLOSSER M, et al. Rate, factors, and outcome of delayed graft function after kidney transplantation of deceased donors[J]. Transplant Proc, 2021, 53(5): 1454-1461. DOI: 10.1016/j.transproceed.2021.01.006.
[4]	KIM DW, TSAPEPAS D, KING KL, et al. Financial impact of delayed graft function in kidney transplantation[J]. Clin Transplant, 2020, 34(10): e14022. DOI: 10.1111/ctr.14022.
[5]	PONTICELLI C, REGGIANI F, MORONI G. Delayed graft function in kidney transplant: risk factors, consequences and prevention strategies[J]. J Pers Med, 2022, 12(10): 1557. DOI: 10.3390/jpm12101557.
[6]	FREITAS MHB, LIMA LC, COUCEIRO TCM, et al. Perioperative factors associated with delayed graft function in renal transplant patients[J]. J Bras Nefrol, 2018, 40(4): 360-365. DOI: 10.1590/2175-8239-JBN-2018-0020.
[7]	KERNIG K, ALBRECHT V, DRÄGER DL, et al. Predictors of delayed graft function in renal transplantation[J]. Urol Int, 2022, 106(5): 512-517. DOI: 10.1159/000520055.
[8]	YE BM, HYEON JM, KIM SJ, et al. Analysis of risk factors for delayed graft function after kidney transplantation[J]. Transplant Proc, 2022, 54(8): 2154-2158. DOI: 10.1016/j.transproceed.2022.07.014.
[9]	张承启, 李易姿, 吴琪俊, 等. 膳食多样化与代谢综合征关系的研究进展[J]. 实用医学杂志, 2022, 38(15): 1970-1974. DOI: 10.3969/j.issn.1006-5725.2022.15.022. ZHANG CQ, LI YZ, WU QJ, et al. Research advances on the relationship between dietary diversity and metabolic syndrome[J]. J Pract Med, 2022, 38(15): 1970-1974. DOI: 10.3969/j.issn.1006-5725.2022.15.022.
[10]	PAMMER LM, LAMINA C, SCHULTHEISS UT, et al. Association of the metabolic syndrome with mortality and major adverse cardiac events: a large chronic kidney disease cohort[J]. J Intern Med, 2021, 290(6): 1219-1232. DOI: 10.1111/joim.13355.
[11]	谷东风, 丁亚楠, 沈蓓莉, 等. 亲属活体肾移植受者术后新发代谢综合征对移植肾功能的影响[J]. 临床肾脏病杂志, 2022, 22(1): 28-33. DOI: 10.3969/j.issn.1671-2390.2022.01.006. GU DF, DING YN, SHEN BL, et al. Effect of onset of metabolic syndrome on allograft function in living donor's kidney transplantation[J]. J Clin Nephrol, 2022, 22(1): 28-33. DOI: 10.3969/j.issn.1671-2390.2022.01.006.
[12]	PALEPU S, PRASAD GV. New-onset diabetes mellitus after kidney transplantation: current status and future directions[J]. World J Diabetes, 2015, 6(3): 445-455. DOI: 10.4239/wjd.v6.i3.445.
[13]	戴天增, 黄雪梅, 方潇, 等. 代谢综合征对移植肾功能延迟恢复及预后的影响[J]. 肾脏病与透析肾移植杂志, 2022, 31(1): 45-51. DOI: 10.3969/j.issn.1006-298X.2022.01.008. DAI TZ, HUANG XM, FANG X, et al. Effect of metabolic syndrome on delayed graft function and prognosis of patients with allograft renal transplantation[J]. Chin J Nephrol Dial Transplant, 2022, 31(1): 45-51. DOI: 10.3969/j.issn.1006-298X.2022.01.008.
[14]	NGUYEN TH, MAT DAUD ZA, ABD TALIB R, et al. Metabolic syndrome and dietary intake are associated with quality of life in kidney transplant recipients[J]. Transplant Proc, 2023, 55(9): 2176-2182. DOI: 10.1016/j.transproceed.2023.08.008.
[15]	National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report[J]. Circulation, 2002, 106(25): 3143-421. DOI: 10.1161/circ.106.25.3143.
[16]	中华医学会糖尿病学分会代谢综合征研究协作组. 中华医学会糖尿病学分会关于代谢综合征的建议[J]. 中华糖尿病杂志, 2004, 12(3): 156-161. DOI: 10.3321/j.issn:1006-6187.2004.03.002. Metabolic Syndrome Research Collaboration Group of the Diabetes Branch of the Chinese Medical Association. Recommendations on metabolic syndrome by the Diabetes Branch of the Chinese Medical Association[J]. Chin Diabetes, 2004, 12(3): 156-161. DOI: 10.3321/j.issn:1006-6187.2004.03.002.
[17]	BAHL D, HADDAD Z, DATOO A, et al. Delayed graft function in kidney transplantation[J]. Curr Opin Organ Transplant, 2019, 24(1): 82-86. DOI: 10.1097/MOT.0000000000000604.
[18]	中华医学会器官移植学分会. 肾移植术后移植物功能延迟恢复诊疗技术规范(2019版)[J]. 器官移植, 2019, 10(5): 521-525. DOI: 10.3969/j.issn.1674-7445.2019.05.010. Branch of Organ Transplantation of Chinese Medical Association. Technical specification for the diagnosis and treatment on delayed graft function after renal transplantation (2019 edition)[J]. Organ Transplant, 2019, 10(5): 521-525. DOI: 10.3969/j.issn.1674-7445.2019.05.010.
[19]	HU XJ, ZHENG J, LI Y, et al. Prediction of kidney transplant outcome based on different DGF definitions in Chinese deceased donation[J]. BMC Nephrol, 2019, 20(1): 409. DOI: 10.1186/s12882-019-1557-x.
[20]	WAZIR S, ABBAS M, RATANASRIMETHA P, et al. Preoperative blood pressure and risk of delayed graft function in deceased donor kidney transplantation[J]. Clin Transplant, 2022, 36(9): e14776. DOI: 10.1111/ctr.14776.
[21]	SHI B, YING T, XU J, et al. Obesity is associated with delayed graft function in kidney transplant recipients: a paired kidney analysis[J]. Transpl Int, 2023, 36: 11107. DOI: 10.3389/ti.2023.11107.
[22]	DELAUTRE A, CHANTREL F, DIMITROV Y, et al. Metabolic syndrome in haemodialysis patients: prevalence, determinants and association to cardiovascular outcomes[J]. BMC Nephrol, 2020, 21(1): 343. DOI: 10.1186/s12882-020-02004-3.
[23]	LEE YH, SONG SH, SONG SH, et al. Clinical implications of changes in metabolic syndrome status after kidney transplantation: a nationwide prospective cohort study[J]. Nephrol Dial Transplant, 2023, 38(12): 2743-2753. DOI: 10.1093/ndt/gfad115.
[24]	PIOTTI G, GANDOLFINI I, PALMISANO A, et al. Metabolic risk profile in kidney transplant candidates and recipients[J]. Nephrol Dial Transplant, 2019, 34(3): 388-400. DOI: 10.1093/ndt/gfy151.
[25]	JARRAR F, TENNANKORE KK, VINSON AJ. Combined donor-recipient obesity and the risk of graft loss after kidney transplantation[J]. Transpl Int, 2022, 35: 10656. DOI: 10.3389/ti.2022.10656.
[26]	钱才媛, 王殿珍, 梅童童, 等. BMI与肾移植术后早期恢复效果的关系[J]. 现代医药卫生, 2022, 38(5): 847-849. DOI: 10.3969/j.issn.1009-5519.2022.05.033. QIAN CY, WANG DZ, MEI TT, et al. The relationship between BMI and early recovery after kidney transplantation[J]. J Mod Med Health, 2022, 38(5): 847-849. DOI: 10.3969/j.issn.1009-5519.2022.05.033.
[27]	SMYRLI M, TSOUKA G, APOSTOLOU T, et al. Body mass index and kidney donor profile index as prognostic markers of the outcome of renal transplantation[J]. Transplant Proc, 2021, 53(9): 2756-2759. DOI: 10.1016/j.transproceed.2021.08.030.
[28]	陈燕铭. 代谢性炎症反应与糖胖病的发生发展[J]. 中山大学学报(医学科学版), 2023, 44(4): 544-550. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0401. CHEN YM. Metaflammation and development of diabesity[J]. J Sun Yat-sen Univ (Med Sci), 2023, 44(4): 544-550. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0401.
[29]	MOLNAR MZ, KOVESDY CP, MUCSI I, et al. Higher recipient body mass index is associated with post-transplant delayed kidney graft function[J]. Kidney Int, 2011, 80(2): 218-224. DOI: 10.1038/ki.2011.114.
[30]	SURESHKUMAR KK, CHOPRA B, JOSEPHSON MA, et al. Recipient obesity and kidney transplant outcomes: a mate-kidney analysis[J]. Am J Kidney Dis, 2021, 78(4): 501-510. DOI: 10.1053/j.ajkd.2021.02.332.
[31]	HILL CJ, COURTNEY AE, CARDWELL CR, et al. Recipient obesity and outcomes after kidney transplantation: a systematic review and meta-analysis[J]. Nephrol Dial Transplant, 2015, 30(8): 1403-1411. DOI: 10.1093/ndt/gfv214.
[32]	GRÈZE C, PEREIRA B, BOIRIE Y, et al. Impact of obesity in kidney transplantation: a prospective cohort study from French registries between 2008 and 2014[J]. Nephrol Dial Transplant, 2022, 37(3): 584-594. DOI: 10.1093/ndt/gfab277.
[33]	FELLMANN M, BALSSA L, CLÉMENT E, et al. Effects of obesity on postoperative complications and graft survival after kidney transplantation[J]. Transplant Proc, 2020, 52(10): 3153-3159. DOI: 10.1016/j.transproceed.2020.02.178.
[34]	LEE JH, MCDONALD EO, HARHAY MN. Obesity management in kidney transplant candidates: current paradigms and gaps in knowledge[J]. Adv Chronic Kidney Dis, 2021, 28(6): 528-541. DOI: 10.1053/j.ackd.2021.09.009.
[35]	SILVA BM, MACEDO FH, HAYANO EEM, et al. Relationship of hemoglobin levels with outcomes in deceased donor kidney transplant: a retrospective cohort study[J]. J Bras Nefrol, 2024,46(2):20230014. DOI: 10.1590/2175-8239-JBN-2023-0014en.
[36]	XUE W, WANG C, CHEN J, et al. A prediction model of delayed graft function in deceased donor for renal transplant: a multi-center study from China[J]. Ren Fail, 2021, 43(1): 520-529. DOI: 10.1080/0886022X.2021.1895838.
[37]	刘佩佳, 方佳, 李少敏, 等. 中老年人群代谢综合征和估算肾小球滤过率快速下降相关性研究[J]. 中山大学学报(医学科学版), 2022, 43(3): 488-495. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2022.0317. LIU PJ, FANG J, LI SM, et al. Association between metabolic syndrome and rapid decline of estimated glomerular filtration rate in middle-aged and elderly populations[J]. J Sun Yat-sen Univ (Med Sci), 2022, 43(3): 488-495. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2022.0317.
[38]	LI X, LIANG Q, ZHONG J, et al. The effect of metabolic syndrome and its individual components on renal function: a meta-analysis[J]. J Clin Med, 2023, 12(4): 1614. DOI: 10.3390/jcm12041614.

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Effect of preoperative metabolic syndrome on early function of renal allografts in kidney transplant recipients

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Effect of preoperative metabolic syndrome on early function of renal allografts in kidney transplant recipients

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