Present situation and progress of xenotransplantation at home and abroad

Zhang Xiaoyan; Wang Guohui; Han Shichao; Qi Ruochen; Liu Kepu; Wei Di; Yang Xiaojian; Ma Shuaijun; Dou Kefeng; Qin Weijun

doi:10.3969/j.issn.1674-7445.2023193

Volume 15 Issue 2

Mar. 2024

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Zhang Xiaoyan, Wang Guohui, Han Shichao, et al. Present situation and progress of xenotransplantation at home and abroad[J]. ORGAN TRANSPLANTATION, 2024, 15(2): 276-281. doi: 10.3969/j.issn.1674-7445.2023193

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Present situation and progress of xenotransplantation at home and abroad

doi: 10.3969/j.issn.1674-7445.2023193

Department of Urology, Xijing Hospital of Air Force Medical University, Xi’an 710032, China

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Corresponding author: Dou Kefeng, Email: doukef@fmmu.edu.cn; Qin Weijun, Email: qinwj@fmmu.edu.cn
Received Date: 2023-12-05
Available Online: 2024-01-24
Publish Date: 2024-03-15

Abstract

Abstract

Organ shortage has become one of the major challenges hindering the development of organ transplantation. Xenotransplantation is one of the most valuable methods to resolve global organ shortage. In recent years, the development of genetic engineering technique and research and development of new immunosuppressant have provided novel theoretical basis for xenotransplantation. International scholars have successively carried out researches on xenotransplantation in genetically modified pigs to non-human primates or brain death recipients, making certain substantial progresses. However, most of the researches are still in the preclinical stage, far from clinical application. Therefore, according to the latest preclinical experimental research progress at home and abroad, the history of xenotransplantation, the development of gene modification technology, xenotransplantation rejection and immunosuppression regimens were reviewed, aiming to provide reference for subsequent research of xenotransplantation, promote clinical application of xenotransplantation and bring benefits to more patients with end-stage diseases.
- Xenotransplantation,
- Genetically modified pig,
- Immunosuppressant,
- Non-human primate,
- Rejection,
- Inflammation,
- Coagulation disorder,
- Infection

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References(43)

References

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Present situation and progress of xenotransplantation at home and abroad

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