Application of immune repertoire sequencing in solid organ transplantation

Liang Lifei; Chen Tingting; Yang Cheng

doi:10.3969/j.issn.1674-7445.2023192

Volume 15 Issue 2

Mar. 2024

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Liang Lifei, Chen Tingting, Yang Cheng. Application of immune repertoire sequencing in solid organ transplantation[J]. ORGAN TRANSPLANTATION, 2024, 15(2): 207-213. doi: 10.3969/j.issn.1674-7445.2023192

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Application of immune repertoire sequencing in solid organ transplantation

doi: 10.3969/j.issn.1674-7445.2023192

Liang Lifei^1
,,
Chen Tingting²,
Yang Cheng^{1, 3
,
,}

1.
Department of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai 200032, China

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Corresponding author: Yang Cheng, Email: esuperyc@163.com
Received Date: 2023-11-07
Accepted Date: 2024-01-17

Available Online: 2024-01-24

Publish Date: 2024-03-15

Abstract

Abstract

Immune repertoire is defined as the sum of T cells and B cells, which possesses high diversity and enables immune system to respond to various antigen stimuli. With the development of sequencing technique, immune repertoire sequencing can be utilized to deeply understand the changes of lymphocyte clones when rejection occurs at the gene level, and also provide the possibility for the emergence of novel non-invasive diagnostic techniques based on immune repertoire sequencing. In recent years, more and more attempts have been made to apply immune repertoire sequencing in solid organ transplantation, especially in the fields of kidney transplantation, liver transplantation, heart transplantation and post-transplantation infection. In this article, research progresses on the application of immune repertoire sequencing in these fields were reviewed, and current status of immune repertoire sequencing in organ transplantation and its potential as a novel technique for early non-invasive diagnosis of rejection were summarized, aiming to provide reference for subsequent development and clinical application of this technique.

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References

[1]	付钰, 杨国胜, 吴松. 免疫组库的临床应用[J]. 国际免疫学杂志, 2014, 37(5): 411-414,423. DOI: 10.3760/cma.j.issn.1673-4394.2014.05.012. FU Y, YANG GS, WU S. Immune repertoire in clinic application[J]. Int J Immunol, 2014, 37(5): 411-414,423. DOI: 10.3760/cma.j.issn.1673-4394.2014.05.012.
[2]	MUSVOSVI M, HUANG H, WANG C, et al. T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection[J]. Nat Med, 2023, 29(1): 258-269. DOI: 10.1038/s41591-022-02110-9.
[3]	FRANK ML, LU K, ERDOGAN C, et al. T-cell receptor repertoire sequencing in the era of cancer immunotherapy[J]. Clin Cancer Res, 2023, 29(6): 994-1008. DOI: 10.1158/1078-0432.CCR-22-2469.
[4]	PAUKEN KE, LAGATTUTA KA, LU BY, et al. TCR-sequencing in cancer and autoimmunity: barcodes and beyond[J]. Trends Immunol, 2022, 43(3): 180-194. DOI: 10.1016/j.it.2022.01.002.
[5]	WONG P, CINA DP, SHERWOOD KR, et al. Clinical application of immune repertoire sequencing in solid organ transplant[J]. Front Immunol, 2023, 14: 1100479. DOI: 10.3389/fimmu.2023.1100479.
[6]	OELLERICH M, SHERWOOD K, KEOWN P, et al. Liquid biopsies: donor-derived cell-free DNA for the detection of kidney allograft injury[J]. Nat Rev Nephrol, 2021, 17(9): 591-603. DOI: 10.1038/s41581-021-00428-0.
[7]	SCHINSTOCK CA, MANNON RB, BUDDE K, et al. Recommended treatment for antibody-mediated rejection after kidney transplantation: the 2019 expert consensus from the Transplantion Society Working Group[J]. Transplantation, 2020, 104(5): 911-922. DOI: 10.1097/TP.0000000000003095.
[8]	JIN Y, GAO P, LIANG L, et al. Noninvasive quantification of granzyme B in cardiac allograft rejection using targeted ultrasound imaging[J]. Front Immunol, 2023, 14: 1164183. DOI: 10.3389/fimmu.2023.1164183.
[9]	GAO T, YI L, WANG Y, et al. Granzyme B-responsive fluorescent probe for non-invasive early diagnosis of transplant rejection[J]. Biosens Bioelectron, 2023, 232: 115303. DOI: 10.1016/j.bios.2023.115303.
[10]	LIU X, WU J. History, applications, and challenges of immune repertoire research[J]. Cell Biol Toxicol, 2018, 34(6): 441-457. DOI: 10.1007/s10565-018-9426-0.
[11]	SIU JHY, SURENDRAKUMAR V, RICHARDS JA, et al. T cell allorecognition pathways in solid organ transplantation[J]. Front Immunol, 2018, 9: 2548. DOI: 10.3389/fimmu.2018.02548.
[12]	DEWOLF S, SYKES M. Alloimmune T cells in transplantation[J]. J Clin Invest, 2017, 127(7): 2473-2481. DOI: 10.1172/JCI90595.
[13]	DAVIS MM, BJORKMAN PJ. T-cell antigen receptor genes and T-cell recognition[J]. Nature, 1988, 334(6181): 395-402. DOI: 10.1038/334395a0.
[14]	PINEDA S, SIGDEL TK, LIBERTO JM, et al. Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing[J]. Nat Commun, 2019, 10(1): 1906. DOI: 10.1038/s41467-019-09930-3.
[15]	BRACIAK TA, PEDERSEN B, CHIN J, et al. Protection against experimental autoimmune encephalomyelitis generated by a recombinant adenovirus vector expressing the V beta 8.2 TCR is disrupted by coadministration with vectors expressing either IL-4 or -10[J]. J Immunol, 2003, 170(2): 765-774. DOI: 10.4049/jimmunol.170.2.765.
[16]	SCHATZ DG, OETTINGER MA, SCHLISSEL MS. V(D)J recombination: molecular biology and regulation[J]. Annu Rev Immunol, 1992, 10: 359-383. DOI: 10.1146/annurev.iy.10.040192.002043.
[17]	ALT FW, OLTZ EM, YOUNG F, et al. VDJ recombination[J]. Immunol Today, 1992, 13(8): 306-314. DOI: 10.1016/0167-5699(92)90043-7.
[18]	LIU H, PAN W, TANG C, et al. The methods and advances of adaptive immune receptors repertoire sequencing[J]. Theranostics, 2021, 11(18): 8945-8963. DOI: 10.7150/thno.61390.
[19]	FU J, KHOSRAVI-MAHARLOOEI M, SYKES M. High throughput human T cell receptor sequencing: a new window into repertoire establishment and alloreactivity[J]. Front Immunol, 2021, 12: 777756. DOI: 10.3389/fimmu.2021.777756.
[20]	张家兴, 陈怀周, 赖柳生, 等. 肾移植术后急性排斥反应相关的T细胞受体免疫组库变化[J]. 中华肾脏病杂志, 2018, 34(4): 281-287. DOI: 10.3760/cma.j.issn.1001-7097.2018.04.009. ZHANG JX, CHEN HZ, LAI LS, et al. Study of T cell receptor in patients with acute rejection after renal transplantation[J]. Chin J Nephrol, 2018, 34(4): 281-287. DOI: 10.3760/cma.j.issn.1001-7097.2018.04.009.
[21]	ASCHAUER C, JELENCSICS K, HU K, et al. Effects of reduced-dose anti-human T-lymphocyte globulin on overall and donor-specific T-cell repertoire reconstitution in sensitized kidney transplant recipients[J]. Front Immunol, 2022, 13: 843452. DOI: 10.3389/fimmu.2022.843452.
[22]	ASCHAUER C, JELENCSICS K, HU K, et al. Prospective tracking of donor-reactive T-cell clones in the circulation and rejecting human kidney allografts[J]. Front Immunol, 2021, 12: 750005. DOI: 10.3389/fimmu.2021.750005.
[23]	LAI L, WANG L, CHEN H, et al. T cell repertoire following kidney transplantation revealed by high-throughput sequencing[J]. Transpl Immunol, 2016, 39: 34-45. DOI: 10.1016/j.trim.2016.08.006.
[24]	FU J, RUST D, FANG Z, et al. T cell repertoire profiling in allografts and native tissues in recipients with COVID-19 after solid organ transplantation: insight into T cell-mediated allograft protection from viral infection[J]. Front Immunol, 2022, 13: 1056703. DOI: 10.3389/fimmu.2022.1056703.
[25]	SHI T, BURG AR, CALDWELL JT, et al. Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality[J]. J Clin Invest, 2023, 133(14): e170191. DOI: 10.1172/JCI170191.
[26]	DUNLAP GS, DITORO D, HENDERSON J, et al. Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy[J]. Nat Commun, 2023, 14(1): 1549. DOI: 10.1038/s41467-023-37230-4.
[27]	SIGDEL TK, FIELDS PA, LIBERTO J, et al. Perturbations of the T-cell immune repertoire in kidney transplant rejection[J]. Front Immunol, 2022, 13: 1012042. DOI: 10.3389/fimmu.2022.1012042.
[28]	ALACHKAR H, MUTONGA M, KATO T, et al. Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection[J]. BMC Nephrol, 2016, 17(1): 181. DOI: 10.1186/s12882-016-0395-3.
[29]	ZHENG B, YANG Y, CHEN L, et al. B-cell receptor repertoire sequencing: deeper digging into the mechanisms and clinical aspects of immune-mediated diseases[J]. iScience, 2022, 25(10): 105002. DOI: 10.1016/j.isci.2022.105002.
[30]	WU TH, LIAO HT, LI TH, et al. High-throughput sequencing of complementarity determining region 3 in the heavy chain of B-cell receptor in renal transplant recipients: a preliminary report[J]. J Clin Med, 2022, 11(11): 2980. DOI: 10.3390/jcm11112980.
[31]	WANG G, SUI W, XUE W, et al. Comprehensive analysis of B and T cell receptor repertoire in patients after kidney transplantation by high-throughput sequencing[J]. Clin Immunol, 2022, 245: 109162. DOI: 10.1016/j.clim.2022.109162.
[32]	FERDMAN J, PORCHERAY F, GAO B, et al. Expansion and somatic hypermutation of B-cell clones in rejected human kidney grafts[J]. Transplantation, 2014, 98(7): 766-772. DOI: 10.1097/TP.0000000000000124.
[33]	YANG G, OU M, CHEN H, et al. Characteristic analysis of TCR β-chain CDR3 repertoire for pre- and post-liver transplantation[J]. Oncotarget, 2018, 9(77): 34506-34519. DOI: 10.18632/oncotarget.26138.
[34]	SAVAGE TM, SHONTS BA, LAU S, et al. Deletion of donor-reactive T cell clones after human liver transplant[J]. Am J Transplant, 2020, 20(2): 538-545. DOI: 10.1111/ajt.15592.
[35]	SHAN Y, QI D, ZHANG L, et al. Single-cell RNA-seq revealing the immune features of donor liver during liver transplantation[J]. Front Immunol, 2023, 14: 1096733. DOI: 10.3389/fimmu.2023.1096733.
[36]	MEDERACKE YS, NIENEN M, JAREK M, et al. T cell receptor repertoires within liver allografts are different to those in the peripheral blood[J]. J Hepatol, 2021, 74(5): 1167-1175. DOI: 10.1016/j.jhep.2020.12.014.
[37]	ZUBER J, SHONTS B, LAU SP, et al. Bidirectional intragraft alloreactivity drives the repopulation of human intestinal allografts and correlates with clinical outcome[J]. Sci Immunol, 2016, 1(4): eaah3732. DOI: 10.1126/sciimmunol.aah3732.
[38]	VOLLMERS C, DE VLAMINCK I, VALANTINE HA, et al. Monitoring pharmacologically induced immunosuppression by immune repertoire sequencing to detect acute allograft rejection in heart transplant patients: a proof-of-concept diagnostic accuracy study[J]. PLoS Med, 2015, 12(10): e1001890. DOI: 10.1371/journal.pmed.1001890.
[39]	KIM JY, LEI Z, MAIENSCHEIN-CLINE M, et al. Longitudinal analysis of the T-cell receptor repertoire in graft-infiltrating lymphocytes following hand transplantation[J]. Transplantation, 2021, 105(7): 1502-1509. DOI: 10.1097/TP.0000000000003535.
[40]	SIM BZ, YONG KY, SLAVIN MA, et al. Risk factors and outcome of concurrent and sequential multiviral cytomegalovirus, Epstein-Barr virus, BK virus, adenovirus and other viral reactivations in transplantation[J]. Curr Opin Infect Dis, 2022, 35(6): 536-544. DOI: 10.1097/QCO.0000000000000888.
[41]	STRANAVOVA L, PELAK O, SVATON M, et al. Heterologous cytomegalovirus and allo-reactivity by shared T cell receptor repertoire in kidney transplantation[J]. Front Immunol, 2019, 10: 2549. DOI: 10.3389/fimmu.2019.02549.
[42]	SMITH C, CORVINO D, BEAGLEY L, et al. T cell repertoire remodeling following post-transplant T cell therapy coincides with clinical response[J]. J Clin Invest, 2019, 129(11): 5020-5032. DOI: 10.1172/JCI128323.
[43]	NGUYEN TH, BIRD NL, GRANT EJ, et al. Maintenance of the EBV-specific CD8⁺ TCRαβ repertoire in immunosuppressed lung transplant recipients[J]. Immunol Cell Biol, 2017, 95(1): 77-86. DOI: 10.1038/icb.2016.71.
[44]	BORRIELLO M, INGROSSO D, PERNA AF, et al. BK virus infection and BK-virus-associated nephropathy in renal transplant recipients[J]. Genes (Basel), 2022, 13(7): 1290. DOI: 10.3390/genes13071290.
[45]	STERVBO U, NIENEN M, WEIST BJD, et al. BKV clearance time correlates with exhaustion state and T-cell receptor repertoire shape of BKV-specific T-cells in renal transplant patients[J]. Front Immunol, 2019, 10: 767. DOI: 10.3389/fimmu.2019.00767.

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Application of immune repertoire sequencing in solid organ transplantation

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