Evolution and innovation of preservation fluid for donor liver

Yu Guotao; Yin Yanfeng; Yan Chuntao; Zou Guangxu; Zhang Huangyan; Ma Li; Hu Zongqiang

doi:10.3969/j.issn.1674-7445.2023165

Volume 15 Issue 1

Jan. 2024

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Yu Guotao, Yin Yanfeng, Yan Chuntao, et al. Evolution and innovation of preservation fluid for donor liver[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 131-137. doi: 10.3969/j.issn.1674-7445.2023165

Citation:

Yu Guotao, Yin Yanfeng, Yan Chuntao, et al. Evolution and innovation of preservation fluid for donor liver[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 131-137. doi: 10.3969/j.issn.1674-7445.2023165

Citation:

Yu Guotao, Yin Yanfeng, Yan Chuntao, et al. Evolution and innovation of preservation fluid for donor liver[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 131-137. doi: 10.3969/j.issn.1674-7445.2023165

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Evolution and innovation of preservation fluid for donor liver

doi: 10.3969/j.issn.1674-7445.2023165

Department of Hepatobiliary Pancreatic Surgery, the First People’s Hospital of Kunming, Kunming 650011, China

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Corresponding author: Hu Zongqiang, Email: 2509484088@qq.com
Received Date: 2023-08-25
Accepted Date: 2023-11-22

Available Online: 2023-11-29

Publish Date: 2024-01-11

Abstract

Abstract

Organ preservation fluid could mitigate cold ischemia injury and maintain normal function of the grafts. At present, how to reduce a series of injury caused by cold ischemia of donor liver and improve the preservation quality of grafts are the hot and challenging spots in this field. Currently, preservation fluid in clinical practice has not achieved ideal preservation effect, especially for the protection of marginal donor organs. In the context of severe donor shortage, the key solution is still to explore the optimal preservation protocol for donor liver to prevent grafts from cold ischemia injury. In this article, the mechanism of donor liver injury during cold ischemia, the classification and evolution of donor liver preservation fluid were summarized, the development direction and challenges of donor liver preservation fluid were discussed, aiming to provide novel ideas and references for the research and development of donor liver preservation fluid.
- Liver transplantation,
- Donor liver,
- Preservation fluid,
- Cold ischemia injury,
- Expanded criteria donor,
- Marginal donor liver,
- Oxidative stress,
- Ischemia-reperfusion injury

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References(39)

References

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Evolution and innovation of preservation fluid for donor liver

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