Research progress on association between macrophages and ischemia-reperfusion injury

Liu Qi; Zhang Yannan; Sun Qiquan

doi:10.3969/j.issn.1674-7445.2023161

Volume 15 Issue 1

Jan. 2024

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Liu Qi, Zhang Yannan, Sun Qiquan. Research progress on association between macrophages and ischemia-reperfusion injury[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 40-45. doi: 10.3969/j.issn.1674-7445.2023161

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Research progress on association between macrophages and ischemia-reperfusion injury

doi: 10.3969/j.issn.1674-7445.2023161

Liu Qi^{1, 2
,},
Zhang Yannan²,
Sun Qiquan^{2
,
,}

1.
School of Medicine, South China University of Technology, Guangzhou 510641, China

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Corresponding author: Sun Qiquan, Email: sunqiquan@gdph.org.cn
Received Date: 2023-08-16
Available Online: 2023-11-29
Publish Date: 2024-01-11

Abstract

Abstract

Ischemia-reperfusion injury (IRI) is an extremely complicated pathophysiological process, which may occur during the process of myocardial infarction, stroke, organ transplantation and temporary interruption of blood flow during surgery, etc. As key molecules of immune system, macrophages play a vital role in the pathogenesis of IRI. M1 macrophages are pro-inflammatory cells and participate in the elimination of pathogens. M2 macrophages exert anti-inflammatory effect and participate in tissue repair and remodeling and extracellular matrix remodeling. The balance between macrophage phenotypes is of significance for the outcome and treatment of IRI. This article reviewed the role of macrophages in IRI, including the balance between M1/M2 macrophage phenotype, the mechanism of infiltration and recruitment into different ischemic tissues. In addition, the potential therapeutic strategies of targeting macrophages during IRI were also discussed, aiming to provide reference for alleviating IRI and promoting tissue repair.
- Ischemia-reperfusion injury,
- Macrophage,
- Inflammation,
- Reactive oxygen species (ROS),
- Chemokine,
- Adhesion factor,
- Anti-inflammatory agent,
- Stem cell therapy

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References(48)

References

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Research progress on association between macrophages and ischemia-reperfusion injury

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