Volume 14 Issue 2
Mar.  2023
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Article Navigation >  ORGAN TRANSPLANTATION  > 2023  >  14(2): 313-318
Xia Zheng, Zhou Lin. Application progress in the role of vitamin D3 in transplantation immunity[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 313-318. doi: 10.3969/j.issn.1674-7445.2023.02.020
Citation: Xia Zheng, Zhou Lin. Application progress in the role of vitamin D3 in transplantation immunity[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 313-318. doi: 10.3969/j.issn.1674-7445.2023.02.020
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Application progress in the role of vitamin D3 in transplantation immunity

doi: 10.3969/j.issn.1674-7445.2023.02.020

  • Zhantansi Department, Centrol Medical Branch of People's Liberation Army General Hospital, Beijing 100034, China

More Information
  • Corresponding author: Zhou Lin, E-mail: commander_fmmu@126.com
  • Received Date: 2022-09-27
    Available Online: 2023-03-15
  • Publish Date: 2023-03-15
    Abstract
  • Vitamin D3 is a kind of vitamin that plays important roles in maintaining the normal physiological function of the human body, and its metabolites and analogues exhibit strong anti-inflammatory activity. Vitamin D3 could be activated and converted into 1α, 25-dihydroxyvitamin D3, a kind of steroid hormone, in the human body, which participates in the regulation of cellular metabolism by activating vitamin D receptor (a kind of transcription factor), thus exerting immunomodulatory effects. This is essential for maintaining the physiological health of the body. Currently, there is a growing number of studies that suggest important roles for 1α, 25-dihydroxyvitamin D3 in organ transplantation immunomodulation and tolerance. Therefore, we reviewed the overview and physiological effects of 1α, 25-dihydroxyvitamin D3, the immunomodulatory effects of vitamin D3 and the application of vitamin D3 in clinical organ transplantation, and summarized the value of applying vitamin D3 in inducing immune tolerance in transplantation, with the aim of providing a reference for promoting the application of vitamin D3 in transplantation immunity.

     

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