Distribution and drug resistance characteristics of pathogens in recipients undergoing simultaneous pancreas-kidney transplantation

Chen Rongxin; Fang Jiali; Zhang Lei; Li Guanghui; Liu Luhao; Zhang Peng; Wu Jialin; Ma Junjie; Guo Zebin; Chen Zheng

doi:10.3969/j.issn.1674-7445.2023.02.015

Volume 14 Issue 2

Mar. 2023

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Chen Rongxin, Fang Jiali, Zhang Lei, et al. Distribution and drug resistance characteristics of pathogens in recipients undergoing simultaneous pancreas-kidney transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 280-287. doi: 10.3969/j.issn.1674-7445.2023.02.015

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Distribution and drug resistance characteristics of pathogens in recipients undergoing simultaneous pancreas-kidney transplantation

doi: 10.3969/j.issn.1674-7445.2023.02.015

Department of Organ Transplantation, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 511447, China

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Corresponding author: Guo Zebin, Email: 76554441@qq.com; Chen Zheng, Email: docchenzheng@163.com
Received Date: 2022-11-15
Available Online: 2023-03-15
Publish Date: 2023-03-15

Abstract

Abstract

Objective To investigate the distribution and drug resistance characteristics of pathogens in donors and recipients undergoing simultaneous pancreas-kidney transplantation (SPK). Methods Clinical data of 231 pairs of donors and recipients undergoing SPK were analyzed retrospectively. The pathogens of samples from donors and recipients were identified by VITEK-2 analyzer, and drug sensitivity test was performed by K-B method. The source distribution and composition ratio of pathogens in donor and recipient samples, distribution characteristics of multi-drug resistant organism, infection of recipients and drug resistance characteristics of pathogens were analyzed. Results A total of 395 strains of pathogens were cultured from 1 294 donor samples, and the detection rate was 30.53%. Gram-negative bacteria mainly consisted of klebsiella pneumoniae, Gram-positive bacteria mainly comprised staphylococcus aureus, and fungi primarily included candida albicans, respectively. In total, 2 690 strains of pathogens were cultured from 10 507 recipient samples, and the detection rate was 25.60%. Gram-negative bacteria mainly consisted of pseudomonas maltophilia, Gram-positive bacteria primarily comprised enterococcus faecalis, and fungi mainly included candida albicans, respectively. Among 395 pathogens of donors, 15 strains of methicillin-resistant staphylococcus aureus (MRSA), 16 strains of extended-spectrum β-lactamase (ESBL) positive drug-resistant bacteria, 8 strains of carbapenem-resistant pseudomonas aeruginosa (CR-PA), 21 strains of carbapenem-resistant acinetobacter baumannii (CR-AB), 2 strains of carbapenem-resistant enterobacteriaceae (CRE) and 1 strain of multiple-drug/pan-drug resistant pseudomonas aeruginosa (MDR/PDR-PA) were identified. Among 2 690 strains of recipient pathogens, 73 strains of ESBL positive drug-resistant bacteria, 44 strains of CR-PA, 31 strains of CR-AB and 3 strains of MDR/PDR-PA were detected. One recipient developed donor-derived infection, 69 cases of pneumonia, 52 cases of urinary tract infection, 35 cases of abdominal infection and 2 cases of hematogenous infection were reported within postoperative 1 year. Gram-negative bacteria were resistant to certain antibiotics. Gram-positive bacteria were sensitive to vancomycin. Fungi were sensitive to amphotericin B. Conclusions Gram-negative bacteria are the main pathogens of SPK recipients, which are resistant to certain antibiotics. Empirical use of antibiotics can be delivered before culture results are obtained. Subsequently, sensitive antibiotics should be chosen according to the culture results to improve the survival rate of SPK recipients.
- Simultaneous pancreas-kidney transplantation,
- Pathogen,
- Multi-drug resistant organism,
- Gram-negative bacteria,
- Gram-positive bacteria,
- Fungi,
- Donor-derived infection,
- Antibiotic

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References

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Distribution and drug resistance characteristics of pathogens in recipients undergoing simultaneous pancreas-kidney transplantation

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Distribution and drug resistance characteristics of pathogens in recipients undergoing simultaneous pancreas-kidney transplantation

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