Preservation and functional maintenance of lung allograft

Hu Chunxiao; Shao Jingbo; Zhao Jin; Chen Jingyu

doi:10.3969/j.issn.1674-7445.2023.02.006

Volume 14 Issue 2

Mar. 2023

Turn off MathJax

Article Contents

Article Navigation > ORGAN TRANSPLANTATION > 2023 > 14(2): 213-219

Hu Chunxiao, Shao Jingbo, Zhao Jin, et al. Preservation and functional maintenance of lung allograft[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 213-219. doi: 10.3969/j.issn.1674-7445.2023.02.006

Citation:

Hu Chunxiao, Shao Jingbo, Zhao Jin, et al. Preservation and functional maintenance of lung allograft[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 213-219. doi: 10.3969/j.issn.1674-7445.2023.02.006

Citation:

Hu Chunxiao, Shao Jingbo, Zhao Jin, et al. Preservation and functional maintenance of lung allograft[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 213-219. doi: 10.3969/j.issn.1674-7445.2023.02.006

PDF( 1428 KB)

Preservation and functional maintenance of lung allograft

doi: 10.3969/j.issn.1674-7445.2023.02.006

The Affiliated Wuxi People's Hospital of Nanjing Medical University, Jiangsu Lung Transplant Center, Wuxi Lung Transplant Center, Wuxi 214023, China

More Information

Corresponding author: Hu Chunxiao, Email: huchunxiao91211@163.com; Chen Jingyu, Email: chenjy@wuxiph.com
Received Date: 2022-12-27
Available Online: 2023-03-15
Publish Date: 2023-03-15

Abstract

Abstract

As the final resolution for end-stage lung disease, lung transplantation can not only significantly prolong the survival, but also remarkably improve the quality of life of recipients. In recent decades, with the advancement of surgical techniques, immunosuppressants and post-transplantation management, the quantity of lung transplantation has been surged around the globe. However, the shortage of donor lung has severely restricted the development of lung transplantation. It is necessary to develop innovative approaches to expand the donor pool. The number of donors and effective preservation and functional maintenance of potential donor lungs play a key role in expanding the donor pool. The quality of donor lung is a critical precondition to ensure the long-term survival of lung transplant recipients. Preservation and functional maintenance of donor lung are of significance for guaranteeing the quality of lung allograft. In this article, research progresses on the management and maintenance of donor lung before procurement, the procurement of donor lung and the preservation and functional maintenance of lung allograft were reviewed, aiming to provide reference for the development of lung transplantation in clinical practice.
- Lung transplantation,
- Donor lung preservation,
- Functional maintenance,
- Primary graft dysfunction,
- Ex vivo lung perfusion,
- Mechanical ventilation,
- Fluid management,
- Hormone

FullText(HTML)

References(47)

References

[1]	HALPERN SE, JAWITZ OK, RAMAN V, et al. Aggressive pursuit and utilization of non-ideal donor lungs does not compromise post-lung transplant survival[J]. Clin Transplant, 2021, 35(9): e14414. DOI: 10.1111/ctr.14414.
[2]	CHAMBERS DC, PERCH M, ZUCKERMANN A, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult lung transplantation report - 2021; focus on recipient characteristics[J]. J Heart Lung Transplant, 2021, 40(10): 1060-1072. DOI: 10.1016/j.healun.2021.07.021.
[3]	焦国慧, 王梓涛, 陈静瑜. 肺移植全球发展概况与展望[J]. 器官移植, 2022, 13(4): 417-424. DOI: 10.3969/j.issn.1674-7445.2022.04.002. JIAO GH, WANG ZT, CHEN JY. Current status and prospect of global development of lung transplantation[J]. Organ Transplant, 2022, 13(4): 417-424. DOI: 10.3969/j.issn.1674-7445.2022.04.002.
[4]	HIRJI SA, HALPERN AL, HELMKAMP LJ, et al. Geographic and temporal patterns of growth in the utilization of donation after circulatory death donors for lung transplantation in the United States[J]. J Heart Lung Transplant, 2020, 39(11): 1313-1315. DOI: 10.1016/j.healun.2020.08.015.
[5]	TAGUE LK, BEDAIR B, WITT C, et al. Lung protective ventilation based on donor size is associated with a lower risk of severe primary graft dysfunction after lung transplantation[J]. J Heart Lung Transplant, 2021, 40(10): 1212-1222. DOI: 10.1016/j.healun.2021.06.016.
[6]	CRINER RN, CLAUSEN E, CANTU E. Primary graft dysfunction[J]. Curr Opin Organ Transplant, 2021, 26(3): 321-327. DOI: 10.1097/MOT.0000000000000876.
[7]	KACZKA DW. Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome[J]. Curr Opin Physiol, 2021, 21: 36-43. DOI: 10.1016/j.cophys.2021.03.006.
[8]	PISANI L, ALGERA AG, SERPA NETO A, et al. Epidemiological characteristics, ventilator management, and clinical outcome in patients receiving invasive ventilation in intensive care units from 10 Asian middle-income countries (PRoVENT-iMiC): an international, multicenter, prospective study[J]. Am J Trop Med Hyg, 2021, 104(3): 1022-1033. DOI: 10.4269/ajtmh.20-1177.
[9]	MASCIA L, PASERO D, SLUTSKY AS, et al. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial[J]. JAMA, 2010, 304(23): 2620-2627. DOI: 10.1001/jama.2010.1796.
[10]	ARJUNA A, MAZZEO AT, TONETTI T, et al. Management of the potential lung donor[J]. Thorac Surg Clin, 2022, 32(2): 143-151. DOI: 10.1016/j.thorsurg.2021.11.005.
[11]	江文诗. 站在亚洲看世界: 亚洲视角下脑死亡器官捐献的可持续健康发展[J]. 器官移植, 2022, 13(6): 697-710. DOI: 10.3969/j.issn.1674-7445.2022.06.003. JIANG WS. With a focus on Asia and a global perspective: sustainable development of donation after brain death[J]. Organ Transplant, 2022, 13(6): 697-710. DOI: 10.3969/j.issn.1674-7445.2022.06.003.
[12]	中华医学会器官移植学分会. 中国肺移植供肺获取与保护技术规范(2019版)[J/CD]. 中华移植杂志(电子版), 2019, 13(2): 87-90. DOI: 10.3877/cma.j.issn.1674-3903.2019.02.002. Branch of Organ Transplantation of Chinese Medical Association. Technical specifications for donor lung acquisition and protection of lung transplantation in China (2019 edition) [J/CD]. Chin J Transplant (Electr Edit), 2019, 13(2): 87-90. DOI: 10.3877/cma.j.issn.1674-3903.2019.02.002.
[13]	龚丽明, 李立, 冉江华, 等. 纤支镜肺泡灌洗在脑死亡边缘性供肺维护中的作用[J]. 昆明医科大学学报, 2022, 43(1): 89-95. DOI: 10.12259/j.issn.2095-610X.S20220107. GONG LM, LI L, RAN JH, et al. The effect of bronchoscopic alveolar lavage on the maintenance of borderline donor lung in brain death[J]. J Kunming Med Univ, 2022, 43(1): 89-95. DOI: 10.12259/j.issn.2095-610X.S20220107.
[14]	MUNSHI L, KESHAVJEE S, CYPEL M. Donor management and lung preservation for lung transplantation[J]. Lancet Respir Med, 2013, 1(4): 318-328. DOI: 10.1016/S2213-2600(12)70064-4.
[15]	HILL B, SMITH C. Central venous pressure monitoring in critical care settings[J]. Br J Nurs, 2021, 30(4): 230-236. DOI: 10.12968/bjon.2021.30.4.230.
[16]	MIÑAMBRES E, COLL E, DUERTO J, et al. Effect of an intensive lung donor-management protocol on lung transplantation outcomes[J]. J Heart Lung Transplant, 2014, 33(2): 178-184. DOI: 10.1016/j.healun.2013.10.034.
[17]	VENKATESWARAN RV, DRONAVALLI V, PATCHELL V, et al. Measurement of extravascular lung water following human brain death: implications for lung donor assessment and transplantation[J]. Eur J Cardiothorac Surg, 2013, 43(6): 1227-1232. DOI: 10.1093/ejcts/ezs657.
[18]	TUTTLE-NEWHALL JE, COLLINS BH, KUO PC, et al. Organ donation and treatment of the multi-organ donor[J]. Curr Probl Surg, 2003, 40(5): 266-310. DOI: 10.1016/S0011-3840(03)00011-X.
[19]	MIÑAMBRES E, RODRIGO E, BALLESTEROS MA, et al. Impact of restrictive fluid balance focused to increase lung procurement on renal function after kidney transplantation[J]. Nephrol Dial Transplant, 2010, 25(7): 2352-2356. DOI: 10.1093/ndt/gfq054.
[20]	LICKER M, HAGERMAN A, BEDAT B, et al. Restricted, optimized or liberal fluid strategy in thoracic surgery: a narrative review[J]. Saudi J Anaesth, 2021, 15(3): 324-334. DOI: 10.4103/sja.sja_1155_20.
[21]	BAYER O, REINHART K, KOHL M, et al. Effects of fluid resuscitation with synthetic colloids or crystalloids alone on shock reversal, fluid balance, and patient outcomes in patients with severe sepsis: a prospective sequential analysis[J]. Crit Care Med, 2012, 40(9): 2543-2551. DOI: 10.1097/CCM.0b013e318258fee7.
[22]	VERZELLONI SEF A, SEF D, TRKULJA V, et al. Postoperative acute kidney injury and renal replacement therapy after DCD lung transplantation[J]. Clin Transplant, 2022, 36(2): e14468. DOI: 10.1111/ctr.14468.
[23]	黄健, 尹攀, 岳冰清, 等. 连续性肾脏替代治疗在肺移植边缘性供肺维护中的临床价值[J]. 临床外科杂志, 2022, 30(10): 994-997. DOI: 10.3969/j.issn.1005-6483.2022.10.027. HUANG J, YIN P, YUE BQ, et al. Study of the clinical value of continuous renal replacement therapy(CRRT) in the maintenance of marginal donor lungs[J]. J Clin Surg, 2022, 30(10): 994-997. DOI: 10.3969/j.issn.1005-6483.2022.10.027.
[24]	VAN BAKEL AB, HINO SA, WELKER D, et al. Hemodynamic effects of high-dose levothyroxine and methylprednisolone in brain-dead potential organ donors[J]. Transplantation, 2022, 106(8): 1677-1689. DOI: 10.1097/TP.0000000000004072.
[25]	KUMAR L. Brain death and care of the organ donor[J]. J Anaesthesiol Clin Pharmacol, 2016, 32(2): 146-152. DOI: 10.4103/0970-9185.168266.
[26]	VENKATESWARAN RV, PATCHELL VB, WILSON IC, et al. Early donor management increases the retrieval rate of lungs for transplantation[J]. Ann Thorac Surg, 2008, 85(1): 278-286. DOI: 10.1016/j.athoracsur.2007.07.092.
[27]	DHAR R, KLINKENBERG D, MARKLIN G. A multicenter randomized placebo-controlled trial of intravenous thyroxine for heart-eligible brain-dead organ donors[J]. Trials, 2021, 22(1): 852. DOI: 10.1186/s13063-021-05797-2.
[28]	DHAR R, STAHLSCHMIDT E, MARKLIN G. A randomized trial of intravenous thyroxine for brain-dead organ donors with impaired cardiac function[J]. Prog Transplant, 2020, 30(1): 48-55. DOI: 10.1177/1526924819893295.
[29]	MACDONALD PS, ANEMAN A, BHONAGIRI D, et al. A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors[J]. Crit Care Med, 2012, 40(5): 1635-1644. DOI: 10.1097/CCM.0b013e3182416ee7.
[30]	VAN RAEMDONCK D, VAN SLAMBROUCK J, CEULEMANS LJ. Donor lung preservation for transplantation-where do we go from here? [J]. J Thorac Dis, 2022, 14(9): 3125-3130. DOI: 10.21037/jtd-22-949.
[31]	KESHAVJEE SH, YAMAZAKI F, CARDOSO PF, et al. A method for safe twelve-hour pulmonary preservation[J]. J Thorac Cardiovasc Surg, 1989, 98(4): 529-534. doi: 10.1016/S0022-5223(19)34354-5
[32]	DATE H, MATSUMURA A, MANCHESTER JK, et al. Evaluation of lung metabolism during successful twenty-four-hour canine lung preservation[J]. J Thorac Cardiovasc Surg, 1993, 105(3): 480-491. doi: 10.1016/S0022-5223(19)34231-X
[33]	KRISHNAN P, SADDOUGHI SS. Procurement of lungs from brain-dead donors[J]. Indian J Thorac Cardiovasc Surg, 2021, 37(Suppl 3): 416-424. DOI: 10.1007/s12055-021-01140-1.
[34]	ZERIOUH M, SABASHNIKOV A, MOHITE PN, et al. Utilization of the organ care system for bilateral lung transplantation: preliminary results of a comparative study[J]. Interact Cardiovasc Thorac Surg, 2016, 23(3): 351-357. DOI: 10.1093/icvts/ivw135.
[35]	BERY A, MARKLIN G, ITOH A, et al. Specialized donor care facility model and advances in management of thoracic organ donors[J]. Ann Thorac Surg, 2022, 113(6): 1778-1786. DOI: 10.1016/j.athoracsur.2020.12.026.
[36]	ABDELNOUR-BERCHTOLD E, ALI A, BACIU C, et al. Evaluation of 10℃ as the optimal storage temperature for aspiration-injured donor lungs in a large animal transplant model[J]. J Heart Lung Transplant, 2022, 41(12): 1679-1688. DOI: 10.1016/j.healun.2022.08.025.
[37]	HAYES D JR, HARTWIG MG, TOBIAS JD, et al. Lung transplant center volume ameliorates adverse influence of prolonged ischemic time on mortality[J]. Am J Transplant, 2017, 17(1): 218-226. DOI: 10.1111/ajt.13916.
[38]	李玉萍, 戴洁, 刘小刚, 等. 供肺冷缺血时间对肺移植预后影响的临床观察[J]. 中华器官移植杂志, 2022, 43(9): 530-535. DOI: 10.3760/cma.j.cn421203-20220521-00118. LI YP, DAI J, LIU XG, et al. Effect of prolonged cold ischemia time on outcomes after lung transplantation[J]. Chin J Organ Transplant, 2022, 43(9): 530-535. DOI: 10.3760/cma.j.cn421203-20220521-00118.
[39]	SEADLER BD, TORO F, SHARMA S. Physiology, alveolar tension[M]. Treasure Island (FL): StatPearls Publishing, 2022.
[40]	HU X, COWL CT, BAQIR M, et al. Air travel and pneumothorax[J]. Chest, 2014, 145(4): 688-694. DOI: 10.1378/chest.13-2363.
[41]	DECAMPOS KN, KESHAVJEE S, LIU M, et al. Optimal inflation volume for hypothermic preservation of rat lungs[J]. J Heart Lung Transplant, 1998, 17(6): 599-607.
[42]	AHMAD K, PLUHACEK JL, BROWN AW. Ex vivo lung perfusion: a review of current and future application in lung transplantation[J]. Pulm Ther, 2022, 8(2): 149-165. DOI: 10.1007/s41030-022-00185-w.
[43]	BISBEE CR, SHERARD C, KWON J, et al. Devices for donor lung preservation[J]. Expert Rev Med Devices, 2022, 19(12): 959-964. DOI: 10.1080/17434440.2022.2151359.
[44]	STEEN S, SJÖBERG T, PIERRE L, et al. Transplantation of lungs from a non-heart-beating donor[J]. Lancet, 2001, 357(9259): 825-829. DOI: 10.1016/S0140-6736(00)04195-7.
[45]	CYPEL M, YEUNG JC, LIU M, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation[J]. N Engl J Med, 2011, 364(15): 1431-1440. DOI: 10.1056/NEJMoa1014597.
[46]	WARNECKE G, VAN RAEMDONCK D, SMITH MA, et al. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study[J]. Lancet Respir Med, 2018, 6(5): 357-367. DOI: 10.1016/S2213-2600(18)30136-X.
[47]	GIVENS C, FATTAH IA, FIORET B, et al. Development and ex vivo functional evaluation of bioengineered lungs[J]. J Heart Lung Transplant, 2019, 38(4): S258. DOI: 10.1016/j.healun.2019.01.640.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1)

Get Citation

PDF

XML

Article Metrics

Article views (352) PDF downloads(75)

Preservation and functional maintenance of lung allograft

doi: 10.3969/j.issn.1674-7445.2023.02.006

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Preservation and functional maintenance of lung allograft

doi: 10.3969/j.issn.1674-7445.2023.02.006

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content