Research progress on the role of bile salts in ischemic-type biliary lesion after liver transplantation

Liu Hanlin; Dai Xin; Xiao Yijun; Wu Wei

doi:10.3969/j.issn.1674-7445.2022.04.019

Volume 13 Issue 4

Jul. 2022

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Liu Hanlin, Dai Xin, Xiao Yijun, et al. Research progress on the role of bile salts in ischemic-type biliary lesion after liver transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 537-542. doi: 10.3969/j.issn.1674-7445.2022.04.019

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Research progress on the role of bile salts in ischemic-type biliary lesion after liver transplantation

doi: 10.3969/j.issn.1674-7445.2022.04.019

Department of Anesthesiology and Pain, the General Hospital of Western Theater Command of Chinese People's Liberation Army, Chengdu 610083, China

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Corresponding author: Wu Wei, Email: wuweizj@163.com
Received Date: 2022-02-08
Available Online: 2022-07-14
Publish Date: 2022-07-15

Abstract

Abstract

Ischemic-type biliary lesion (ITBL) refers to biliary tract injury caused by insufficient blood supply of hepatic artery, which is one of the main factors affecting the long-term survival and quality of life of liver transplant recipients. The incidence of ITBL is associated with cold and warm ischemia, acute and chronic rejection, cytomegalovirus infection and the bile effect, etc. The occurrence of ITBL is a complicated process involving with multiple factors and steps. The therapeutic option of ITBL is extremely limited. A large proportion of ITBL patients should undergo repeated liver transplantation. ITBL has become one of the most critical factors preventing further advancement of liver transplantation. Hence, it is of significance to strengthen prevention and explore more effective modalities. Recent studies have found that toxic injury of bile salts plays a central role in ITBL. Active regulation of bile components, regulation of bile acid-related receptor expression and blockage or activation of bile acid-related signaling pathways probably have potentials in the prevention and treatment of ITBL. In this article, the cytotoxicity of bile salts and the mechanism of bicarbonate umbrella in the incidence and progression of ITBL after liver transplantation were reviewed, aiming to provide reference for the diagnosis and treatment of ITBL.
- Bile salt,
- Phospholipid,
- Liver transplantation,
- Ischemic-type biliary lesion (ITBL),
- Ischemia-reperfusion injury,
- Bicarbonate umbrella,
- Anion exchanger 2,
- Soluble adenylyl cyclase (sAC)

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Research progress on the role of bile salts in ischemic-type biliary lesion after liver transplantation

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