Volume 13 Issue 4
Jul.  2022
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Xiong Yan, Ye Qifa, Kong Fanhua, et al. Diagnostic criteria and research progress on Banff classification of allograft pathology in composite tissue allotransplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 425-433. doi: 10.3969/j.issn.1674-7445.2022.04.003
Citation: Xiong Yan, Ye Qifa, Kong Fanhua, et al. Diagnostic criteria and research progress on Banff classification of allograft pathology in composite tissue allotransplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 425-433. doi: 10.3969/j.issn.1674-7445.2022.04.003

Diagnostic criteria and research progress on Banff classification of allograft pathology in composite tissue allotransplantation

doi: 10.3969/j.issn.1674-7445.2022.04.003
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  • Composite tissue allotransplantation (CTA) is a novel transplantation discipline to treat functional tissue or limb defects. Since a majority of CTA grafts were vascularized grafts, it is also known as vascularized composite allotransplantation (VCA). The grafts of CTA/VCA consist of two or more types of allogeneic skin, subcutaneous tissue, bone, muscle, nerve and vessel, etc. Most of CTA/VCA grafts contain skin tissues, which possess the highest antigenicity. Acute rejection after transplantation is the primary obstacle leading to CTA/VCA graft failure and primary graft dysfunction. Hence, histopathological characteristics of skin rejection in CTA/VCA grafts have become the primary hotspot. In this article, pathological features of CTA/VCA rejection, Banff classification in 2007 and related research progress were reviewed, aiming to provide reference for the diagnosis and treatment of rejection and other complications of CTA/VCA.

     

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