Research progress of NF-κB signaling pathway in kidney ischemia-reperfusion injury

Zhang Ruibo; Shen Kaiwen; Yuan Qiang; Wang Qiang; Shen Jun

doi:10.3969/j.issn.1674-7445.2022.03.011

Volume 13 Issue 3

May 2022

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Article Navigation > ORGAN TRANSPLANTATION > 2022 > 13(3): 349-355

Zhang Ruibo, Shen Kaiwen, Yuan Qiang, et al. Research progress of NF-κB signaling pathway in kidney ischemia-reperfusion injury[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 349-355. doi: 10.3969/j.issn.1674-7445.2022.03.011

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Research progress of NF-κB signaling pathway in kidney ischemia-reperfusion injury

doi: 10.3969/j.issn.1674-7445.2022.03.011

Guizhou Medical University, Guiyang 550004, China

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Corresponding author: Shen Jun, Email: shenjun@gmc.edu.cn
Received Date: 2022-02-22
Available Online: 2022-04-29
Publish Date: 2022-05-15

Abstract

Abstract

Kidney ischemia-reperfusion injury (IRI) is the major cause of poor prognosis after kidney transplantation and partial nephrectomy. Besides, it is also a critical pathophysiological process of acute kidney injury. Consequently, the prevention and treatment of kidney IRI are of significance to improve clinical prognosis of recipients undergoing kidney transplantation. However, the mechanism underlying IRI is complex, and the exact mechanism remains elusive. Inflammation, as one of the main pathogenesis of IRI, plays a significant role in IRI-induced kidney injury. Nuclear factor (NF)-κB, as a rapid response transcription factor, has been proven to be involved in the regulation of inflammation during kidney IRI. Therefore, in this article, the structure of NF-κB, the activation pattern of NF-κB signaling pathway, the regulatory mechanisms of NF-κB upstream and downstream signaling pathways in kidney IRI were reviewed, and the role of NF-κB signaling pathway in kidney IRI was investigated, aiming to provide novel clinical ideas for the prevention and treatment of kidney IRI.

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References

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Research progress of NF-κB signaling pathway in kidney ischemia-reperfusion injury

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