Volume 13 Issue 2
Mar.  2022
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Article Navigation >  ORGAN TRANSPLANTATION  > 2022  >  13(2): 144-160
China Liver Transplant Registry, National Center for Healthcare Quality Management in Liver Transplant, National Quality Control Center for Human Donated Organ Procurement, et al. Chinese expert consensus on organ protection of transplantation (2022 edition)[J]. ORGAN TRANSPLANTATION, 2022, 13(2): 144-160. doi: 10.3969/j.issn.1674-7445.2022.02.002
Citation: China Liver Transplant Registry, National Center for Healthcare Quality Management in Liver Transplant, National Quality Control Center for Human Donated Organ Procurement, et al. Chinese expert consensus on organ protection of transplantation (2022 edition)[J]. ORGAN TRANSPLANTATION, 2022, 13(2): 144-160. doi: 10.3969/j.issn.1674-7445.2022.02.002
shu

Chinese expert consensus on organ protection of transplantation (2022 edition)

doi: 10.3969/j.issn.1674-7445.2022.02.002

  • Department of Hepatobiliary and Pancreatic Surgery, Shulan(Hangzhou)Hospital, Hangzhou 310003 China

  • Received Date: 2022-02-14
    Available Online: 2022-03-18
  • Publish Date: 2022-03-15
    Abstract
  • Organ transplantation is the most effective treatment for end-stage organ failure, and voluntary donation after citizen's death is the only source of transplant organ in China. Clinically, transplant organ protection technique plays a critical role in improving the quality of transplant organs and the prognosis of recipients. On the basis of domestic and worldwide basic research and clinical practice of transplant organ protection and according to the Oxford evidence classification and GRADE system, the experts organized by Branch of Organ Transplant Physicians of Chinese Medical Doctor Association, Branch of Transplantation Group of Surgery of Chinese Medical Association and China Liver Transplant Registry Scientific Committee had compiled and published the Chinese Expert Consensus on Organ Protection of Transplantation (2016 edition) for liver, kidney, pancreas, small intestine, heart, lung transplant organs. With the support of China Liver Transplant Registry, National Trauma Medical Center, National Quality Control Center for Human Donated Organ Procurement, National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation and National Center for Healthcare Quality Management in Liver Transplant combined with recent domeatic and worldwide clinical practice and research progress for organ transplantation and organ protection, the Chinese Expert Consensus on Organ Protection of Transplantation (2022 edition) has been published recently. This consensus focuses on updating the technical progress and evidence-based medicine of organ procurement, preservation, transport, and quality evaluation in clinical practice. Additionally, the content of composite tissue transplantation mainly including limb transplantation has also been covered. The aim is to promote the the scientific and standardized clinical organ transplantation.

     

    • Corresponding author: Zheng Shusen, Email: shusenzheng@zju.edu.cn
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  • [1]
    中国医师协会器官移植医师分会, 中华医学会外科学分会移植学组, 中国肝移植注册中心科学委员会. 中国移植器官保护专家共识(2016版)[J]. 中华消化外科杂志, 2016, 15(7): 645-654. DOI: 10.3760/cma.j.issn.1673-9752.2016.07.001.

    Branch of Organ Transplant Physicians of Chinese Medical Doctor Association, Branch of Transplantation Group of Surgery of Chinese Medical Association, China Liver Transplant Registry Scientific Committ. Chinese expert consensus on the organ protection of transplantation (2016 edition)[J]. Chin J Dig Surg, 2016, 15(7): 645-654. DOI: 10.3760/cma.j.issn.1673-9752.2016.07.001.
    [2]
    VAN RIJN R, SCHURINK IJ, DE VRIES Y, et al. Hypothermic machine perfusion in liver transplantation-a randomized trial[J]. N Engl J Med, 2021, 384(15): 1391-1401. DOI: 10.1056/NEJMoa2031532.
    [3]
    CHEN Y, SHI J, XIA TC, et al. Preservation solutions for kidney transplantation: history, advances and mechanisms[J]. Cell Transplant, 2019, 28(12): 1472-1489. DOI: 10.1177/0963689719872699.
    [4]
    MOHR A, BROCKMANN JG, BECKER F. HTK-N: modified histidine-tryptophan-ketoglutarate solution-a promising new tool in solid organ preservation[J]. Int J Mol Sci, 2020, 21(18): 6468. DOI: 10.3390/ijms21186468.
    [5]
    PAGANO F, NOCELLA C, SCIARRETTA S, et al. Cytoprotective and antioxidant effects of steen solution on human lung spheroids and human endothelial cells[J]. Am J Transplant, 2017, 17(7): 1885-1894. DOI: 10.1111/ajt.14278.
    [6]
    MINOR T, PAUL A, EFFERZ P, et al. Kidney transplantation after oxygenated machine perfusion preservation with Custodiol-N solution[J]. Transpl Int, 2015, 28(9): 1102-1108. DOI: 10.1111/tri.12593.
    [7]
    DE VRIES RJ, TESSIER SN, BANIK PD, et al. Supercooling extends preservation time of human livers[J]. Nat Biotechnol, 2019, 37(10): 1131-1136. DOI: 10.1038/s41587-019-0223-y.
    [8]
    NASRALLA D, COUSSIOS CC, MERGENTAL H, et al. A randomized trial of normothermic preservation in liver transplantation[J]. Nature, 2018, 557(7703): 50-56. DOI: 10.1038/s41586-018-0047-9.
    [9]
    ESHMUMINOV D, BECKER D, BAUTISTA BORREGO L, et al. An integrated perfusion machine preserves injured human livers for 1 week[J]. Nat Biotechnol, 2020, 38(2): 189-198. DOI: 10.1038/s41587-019-0374-x.
    [10]
    JOCHMANS I, BRAT A, DAVIES L, et al. Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial[J]. Lancet, 2020, 396(10263): 1653-1662. DOI: 10.1016/S0140-6736(20)32411-9.
    [11]
    WARNECKE G, VAN RAEMDONCK D, SMITH MA, et al. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study[J]. Lancet Respir Med, 2018, 6(5): 357-367. DOI: 10.1016/S2213-2600(18)30136-X.
    [12]
    HUSEN P, BOFFA C, JOCHMANS I, et al. Oxygenated end-hypothermic machine perfusion in expanded criteria donor kidney transplant: a randomized clinical trial[J]. JAMA Surg, 2021, 156(6): 517-525. DOI: 10.1001/jamasurg.2021.0949.
    [13]
    BROZEK JL, AKL EA, JAESCHKE R, et al. Grading quality of evidence and strength of recommendations in clinical practice guidelines: part 2 of 3. the GRADE approach to grading quality of evidence about diagnostic tests and strategies[J]. Allergy, 2009, 64(8): 1109-1116. DOI: 10.1111/j.1398-9995.2009.02083.x.
    [14]
    ANTOINE C, JASSERON C, DONDERO F, et al. Liver transplantation from controlled donors after circulatory death using normothermic regional perfusion: an initial french experience[J]. Liver Transpl, 2020, 26(11): 1516-1521. DOI: 10.1002/lt.25818.
    [15]
    RASTOGI AN, YADAV SK, SOIN AS. Organ procurement in the brain dead donors without in vivo cold perfusion: a novel technique[J]. J Clin Exp Hepatol, 2020, 10(5): 462-466. DOI: 10.1016/j.jceh.2019.12.007.
    [16]
    中华医学会器官移植学分会, 中华医学会外科学分会移植学组, 中国医师协会器官移植医师分会. 中国心脏死亡捐献器官评估与应用专家共识[J/CD]. 中华移植杂志(电子版), 2014, 8(3): 117-122. DOI: 10.3877/cma.j.issn.1647-3903.2014.03.001.

    Branch of Organ Transplantation of Chinese Medical Association, Branch of Transplantation Group of Surgery of Chinese Medical Association, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association. Expert consensus on evaluation and application of organ donated after cardiac death in China[J/CD]. Chin J Transplant (Electr Edit), 2014, 8(3): 117-122. DOI: 10.3877/cma.j.issn.1647-3903.2014.03.001.
    [17]
    LAUTERIO A, DI SANDRO S, GRUTTADAURIA S, et al. Donor safety in living donor liver donation: an Italian multicenter survey[J]. Liver Transpl, 2017, 23(2): 184-193. DOI: 10.1002/lt.24651.
    [18]
    ASSALINO M, MAJNO P, TOSO C, et al. In situ liver splitting under extracorporeal membrane oxygenation in brain-dead donor[J]. Am J Transplant, 2018, 18(1): 258-261. DOI: 10.1111/ajt.14461.
    [19]
    AGOPIAN VG, HARLANDER-LOCKE MP, MARKOVIC D, et al. Evaluation of early allograft function using the liver graft assessment following transplantation risk score model[J]. JAMA Surg, 2018, 153(5): 436-444. DOI: 10.1001/jamasurg.2017.5040.
    [20]
    KALISVAART M, CROOME KP, HERNANDEZ-ALEJANDRO R, et al. Donor warm ischemia time in DCD Liver Transplantation-Working Group report from the ILTS DCD, liver preservation, and machine perfusion consensus conference[J]. Transplantation, 2021, 105(6): 1156-1164. DOI: 10.1097/TP.0000000000003819.
    [21]
    中华医学会器官移植学分会, 中华医学会外科学分会移植学组, 中国医师协会器官移植医师分会. 中国心脏死亡捐献器官评估与应用专家共识(2014版)[J]. 中华消化外科杂志, 2015, 14(1): 6-12. DOI: 10.3760/cma.j.issn.1673-9752.2015.01.002.

    Branch of Organ Transplantation of Chinese Medical Association, Branch of Transplantation Group of Surgery of Chinese Medical Association, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association. Expert consensus on evaluation and application of organ donation after cardiac death in China (2014 edition)[J]. Chin J Dig Surg, 2015, 14(1): 6-12. DOI: 10.3760/cma.j.issn.1673-9752.2015.01.002.
    [22]
    ADAM R, CAILLIEZ V, SEGEV D, et al. A systematic review and Meta-analysis of cold in situ perfusion and preservation of the hepatic allograft: working toward a unified approach[J]. Liver Transpl, 2018, 24(8): 1142-1143. DOI: 10.1002/lt.25208.
    [23]
    ZHOU ZJ, CHEN GS, SI ZZ, et al. Prognostic factors influencing outcome in adult liver transplantation using hypernatremic organ donation after brain death[J]. Hepatobiliary Pancreat Dis Int, 2020, 19(4): 371-377. DOI: 10.1016/j.hbpd.2020.06.003.
    [24]
    中华医学会器官移植学分会. 中国肝移植供肝获取技术规范(2019版)[J/CD]. 中华移植杂志(电子版), 2019, 13(3): 167-170. DOI: 10.3877/cma.j.issn.1674-3903.2019.03.002.

    Branch of Organ Transplantation of Chinese Medical Association. Technical specification for donor liver transplantation in China (2019 edition)[J/CD]. Chin J Transplant (Electr Edit), 2019, 13(3): 167-170. DOI: 10.3877/cma.j.issn.1674-3903.2019.03.002.
    [25]
    CORPS CL, AHMED I, MCKENZIE S, et al. Functional and histological comparison of rat liver preserved in University of Wisconsin solution compared with tissue preserved in a novel solution[J]. Transplant Proc, 2010, 42(9): 3427-3430. DOI: 10.1016/j.transproceed.2010.06.029.
    [26]
    YAGI S, DOORSCHODT BM, AFIFY M, et al. Improved preservation and microcirculation with POLYSOL after partial liver transplantation in rats[J]. J Surg Res, 2011, 167(2): e375-e383. DOI: 10.1016/j.jss.2010.12.040.
    [27]
    HONG JC, YERSIZ H, KOSITAMONGKOL P, et al. Liver transplantation using organ donation after cardiac death: a clinical predictive index for graft failure-free survival[J]. Arch Surg, 2011, 146(9): 1017-1023. DOI: 10.1001/archsurg.2011.240.
    [28]
    JAY C, LADNER D, WANG E, et al. A comprehensive risk assessment of mortality following donation after cardiac death liver transplant-an analysis of the national registry[J]. J Hepatol, 2011, 55(4): 808-813. DOI: 10.1016/j.jhep.2011.01.040.
    [29]
    ABBASI J. Supercooling triples liver preservation time[J]. JAMA, 2019, 322(18): 1756. DOI: 10.1001/jama.2019.17613.
    [30]
    DE VRIES RJ, TESSIER SN, BANIK PD, et al. Subzero non-frozen preservation of human livers in the supercooled state[J]. Nat Protoc, 2020, 15(6): 2024-2040. DOI: 10.1038/s41596-020-0319-3.
    [31]
    KRON P, SCHLEGEL A, MANCINA L, et al. Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans[J]. J Hepatol, 2018, 68(1): 82-91. DOI: 10.1016/j.jhep.2017.08.028.
    [32]
    RAYAR M, MAILLOT B, BERGEAT D, et al. A preliminary clinical experience using hypothermic oxygenated machine perfusion for rapid recovery of octogenarian liver grafts[J]. Prog Transplant, 2019, 29(1): 97-98. DOI: 10.1177/1526924818817072.
    [33]
    CUSSA D, PATRONO D, CATALANO G, et al. Use of dual hypothermic oxygenated machine perfusion to recover extended criteria pediatric liver grafts[J]. Liver Transpl, 2020, 26(6): 835-839. DOI: 10.1002/lt.25759.
    [34]
    VAN RIJN R, VAN LEEUWEN OB, MATTON APM, et al. Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers[J]. Liver Transpl, 2018, 24(5): 655-664. DOI: 10.1002/lt.25023.
    [35]
    LAI Q, RUBERTO F, MELANDRO F, et al. Hypothermic oxygenated perfusion for a steatotic liver graft[J]. Hepatobiliary Pancreat Dis Int, 2020, 19(1): 88-90. DOI: 10.1016/j.hbpd.2019.05.012.
    [36]
    TCHILIKIDI KY. Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion[J]. World J Gastrointest Surg, 2019, 11(3): 126-142. DOI: 10.4240/wjgs.v11.i3.126.
    [37]
    MACCONMARA M, HANISH SI, HWANG CS, et al. Making every liver count: increased transplant yield of donor livers through normothermic machine perfusion[J]. Ann Surg, 2020, 272(3): 397-401. DOI: 10.1097/SLA.0000000000004198.
    [38]
    LEMBACH JAHNSEN H, MERGENTAL H, PERERA MTPR, et al. Ex-situ liver preservation with machine preservation[J]. Curr Opin Organ Transplant, 2021, 26(2): 121-132. DOI: 10.1097/MOT.0000000000000864.
    [39]
    LEGEAI C, DURAND L, SAVOYE E, et al. Effect of preservation solutions for static cold storage on kidney transplantation outcomes: a national registry study[J]. Am J Transplant, 2020, 20(12): 3426-3442. DOI: 10.1111/ajt.15995.
    [40]
    TINGLE SJ, FIGUEIREDO RS, MOIR JA, et al. Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation[J]. Cochrane Database Syst Rev, 2019, 3(3): CD011671. DOI: 10.1002/14651858.CD011671.pub2.
    [41]
    DE BEULE J, FIEUWS S, MONBALIU D, et al. The effect of IGL-1 preservation solution on outcome after kidney transplantation: a retrospective single-center analysis[J]. Am J Transplant, 2021, 21(2): 830-837. DOI: 10.1111/ajt.16302.
    [42]
    LE MEUR Y, BADET L, ESSIG M, et al. First-in-human use of a marine oxygen carrier (M101) for organ preservation: a safety and proof-of-principle study[J]. Am J Transplant, 2020, 20(6): 1729-1738. DOI: 10.1111/ajt.15798.
    [43]
    HAMED M, LOGAN A, GRUSZCZYK AV, et al. Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia-reperfusion injury in kidney transplantation models[J]. Br J Surg, 2021, 108(9): 1072-1081. DOI: 10.1093/bjs/znab108.
    [44]
    KOX J, MOERS C, MONBALIU D, et al. The benefits of hypothermic machine preservation and short cold ischemia times in deceased donor kidneys[J]. Transplantation, 2018, 102(8): 1344-1350. DOI: 10.1097/TP.0000000000002188.
    [45]
    PETERS-SENGERS H, HOUTZAGER JHE, IDU MM, et al. Impact of cold ischemia time on outcomes of deceased donor kidney transplantation: an analysis of a national registry[J]. Transplant Direct, 2019, 5(5): e448. DOI: 10.1097/TXD.0000000000000888.
    [46]
    DE DEKEN J, KOCABAYOGLU P, MOERS C. Hypothermic machine perfusion in kidney transplantation[J]. Curr Opin Organ Transplant, 2016, 21(3): 294-300. DOI: 10.1097/MOT.0000000000000306.
    [47]
    BRAT A, DE VRIES KM, VAN HEURN EWE, et al. Hypothermic machine perfusion as a national standard preservation method for deceased donor kidneys[J]. Transplantation, 2021, DOI: 10.1097/TP.0000000000003845 [Epub ahead of print].
    [48]
    FOUCHER Y, FOURNIER MC, LEGENDRE C, et al. Comparison of machine perfusion versus cold storage in kidney transplant recipients from expanded criteria donors: a cohort-based study[J]. Nephrol Dial Transplant, 2020, 35(6): 1043-1070. DOI: 10.1093/ndt/gfz175.
    [49]
    DING CG, TIAN PX, DING XM, et al. Beneficial effect of moderately increasing hypothermic machine perfusion pressure on donor after cardiac death renal transplantation[J]. Chin Med J (Engl), 2018, 131(22): 2676-2682. DOI: 10.4103/0366-6999.245274.
    [50]
    MEISTER FA, CZIGANY Z, RIETZLER K, et al. Decrease of renal resistance during hypothermic oxygenated machine perfusion is associated with early allograft function in extended criteria donation kidney transplantation[J]. Sci Rep, 2020, 10(1): 17726. DOI: 10.1038/s41598-020-74839-7.
    [51]
    GUZZI F, KNIGHT SR, PLOEG RJ, et al. A systematic review to identify whether perfusate biomarkers produced during hypothermic machine perfusion can predict graft outcomes in kidney transplantation[J]. Transpl Int, 2020, 33(6): 590-602. DOI: 10.1111/tri.13593.
    [52]
    DARIUS T, VERGAUWEN M, SMITH T, et al. Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model[J]. Am J Transplant, 2020, 20(8): 2030-2043. DOI: 10.1111/ajt.15800.
    [53]
    MATOS ACC, REQUIAO MOURA LR, BORRELLI M, et al. Impact of machine perfusion after long static cold storage on delayed graft function incidence and duration and time to hospital discharge[J]. Clin Transplant, 2018, 32(1): e13130. DOI: 10.1111/ctr.13130.
    [54]
    WSZOLA M, DOMAGALA P, OSTASZEWSKA A, et al. Time of cold storage prior to start of hypothermic machine perfusion and its influence on graft survival[J] Transplant Proc, 2019, 51(8): 2514-2519. DOI: 10.1016/j.transproceed.2019.02.052.
    [55]
    ROGERS N, WYBURN K. COMPARE trial: new hope for organ preservation[J]. Lancet, 2020, 396(10263): 1609-1611. DOI: 10.1016/S0140-6736(20)32440-5.
    [56]
    DIRITO JR, HOSGOOD SA, TIETJEN GT, et al. The future of marginal kidney repair in the context of normothermic machine perfusion[J]. Am J Transplant, 2018, 18(10): 2400-2408. DOI: 10.1111/ajt.14963.
    [57]
    ELLIOTT TR, NICHOLSON ML, HOSGOOD SA. Normothermic kidney perfusion: an overview of protocols and strategies[J]. Am J Transplant, 2021, 21(4): 1382-1390. DOI: 10.1111/ajt.16307.
    [58]
    RIJKSE E, DE JONGE J, KIMENAI HJAN, et al. Safety and feasibility of 2 h of normothermic machine perfusion of donor kidneys in the Eurotransplant senior program[J]. BJS Open, 2021, 5(1): zraa024. DOI: 10.1093/bjsopen/zraa024.
    [59]
    WEISSENBACHER A, LO FARO L, BOUBRIAK O, et al. Twenty-four-hour normothermic perfusion of discarded human kidneys with urine recirculation[J]. Am J Transplant, 2019, 19(1): 178-192. DOI: 10.1111/ajt.14932.
    [60]
    ARYKBAEVA AS, DE VRIES DK, DOPPENBERG JB, et al. Metabolic needs of the kidney graft undergoing normothermic machine perfusion[J]. Kidney Int, 2021, 100(2): 301-310. DOI: 10.1016/j.kint.2021.04.001.
    [61]
    KATHS JM, CEN JY, CHUN YM, et al. Continuous normothermic ex vivo kidney perfusion is superior to brief normothermic perfusion following static cold storage in donation after circulatory death pig kidney transplantation[J]. Am J Transplant, 2017, 17(4): 957-969. DOI: 10.1111/ajt.14059.
    [62]
    KATHS JM, ECHEVERRI J, LINARES I, et al. Normothermic ex vivo kidney perfusion following static cold storage-brief, intermediate, or prolonged perfusion for optimal renal graft reconditioning?[J]. Am J Transplant, 2017, 17(10): 2580-2590. DOI: 10.1111/ajt.14294.
    [63]
    HOSGOOD SA, THOMPSON E, MOORE T, et al. Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors[J]. Br J Surg, 2018, 105(4): 388-394. DOI: 10.1002/bjs.10733.
    [64]
    KATHS JM, HAMAR M, ECHEVERRI J, et al. Normothermic ex vivo kidney perfusion for graft quality assessment prior to transplantation[J]. Am J Transplant, 2018, 18(3): 580-589. DOI: 10.1111/ajt.14491.
    [65]
    URBANELLIS P, HAMAR M, KATHS JM, et al. Normothermic ex vivo kidney perfusion improves early DCD graft function compared with hypothermic machine perfusion and static cold storage[J]. Transplantation, 2020, 104(5): 947-955. DOI: 10.1097/TP.0000000000003066.
    [66]
    MINOR T, VON HORN C, GALLINAT A, et al. First-in-man controlled rewarming and normothermic perfusion with cell-free solution of a kidney prior to transplantation[J]. Am J Transplant, 2020, 20(4): 1192-1195. DOI: 10.1111/ajt.15647.
    [67]
    JURIASINGANI S, JACKSON A, ZHANG MY, et al. Evaluating the effects of subnormothermic perfusion with AP39 in a novel blood-free model of ex vivo kidney preservation and reperfusion[J]. Int J Mol Sci, 2021, 22(13): 7180. DOI: 10.3390/ijms22137180.
    [68]
    THOMPSON ER, BATES L, IBRAHIM IK, et al. Novel delivery of cellular therapy to reduce ischemia reperfusion injury in kidney transplantation[J]. Am J Transplant, 2021, 21(4): 1402-1414. DOI: 10.1111/ajt.16100.
    [69]
    HOLT RIG, DEVRIES JH, HESS-FISCHL A, et al. The management of type 1 diabetes in adults. a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)[J]. Diabetes Care, 2021, 44(11): 2589-2625. DOI: 10.2337/dci21-0043.
    [70]
    SHYR BS, SHYR BU, CHEN SC, et al. A comparative study of pancreas transplantation between type 1 and 2 diabetes mellitus[J]. Hepatobiliary Surg Nutr, 2021, 10(4): 443-453. DOI: 10.21037/hbsn-19-422.
    [71]
    KUAN KG, WEE MN, CHUNG WY, et al. Extracorporeal machine perfusion of the pancreas: technical aspects and its clinical implications--a systematic review of experimental models[J]. Transplant Rev (Orlando), 2016, 30(1): 31-47. DOI: 10.1016/j.trre.2015.06.002.
    [72]
    中华医学会器官移植学分会. 胰腺移植临床技术操作规范[J]. 中华器官移植杂志, 2019, 40(11): 643-659. DOI: 10.3760/cma.j.issn.0254-1785.2019.11.002.

    Branch of Organ Transplantation of Chinese Medical Association. Clinical technical operation specification of pancreas transplantation[J]. Chin J Organ Transplant, 2019, 40(11): 643-659. DOI: 10.3760/cma.j.issn.0254-1785.2019.11.002.
    [73]
    HAMAOUI K, PAPALOIS V. Machine perfusion and the pancreas: will it increase the donor pool?[J]. Curr Diab Rep, 2019, 19(8): 56. DOI: 10.1007/s11892-019-1165-y.
    [74]
    DOPPENBERG JB, NIJHOFF MF, ENGELSE MA, et al. Clinical use of donation after circulatory death pancreas for islet transplantation[J]. Am J Transplant, 2021, 21(9): 3077-3087. DOI: 10.1111/ajt.16533.
    [75]
    DHOLAKIA S, ROYSTON E, SHARPLES EJ, et al. Preserving and perfusing the allograft pancreas: past, present, and future[J]. Transplant Rev (Orlando), 2018, 32(3): 127-131. DOI: 10.1016/j.trre.2018.02.001.
    [76]
    PRUDHOMME T, RENAUDIN K, LO FARO ML, et al. Ex situ hypothermic perfusion of nonhuman primate pancreas: a feasibility study[J]. Artif Organs, 2020, 44(7): 736-743. DOI: 10.1111/aor.13655.
    [77]
    STEWART ZA, CAMERON AM, SINGER AL, et al. Histidine-tryptophan-ketoglutarate (HTK) is associated with reduced graft survival in pancreas transplantation[J]. Am J Transplant, 2009, 9(1): 217-221. DOI: 10.1111/j.1600-6143.2008.02449.x.
    [78]
    KUWAE K, MIYAGI-SHIOHIRA C, HAMADA E, et al. Excellent islet yields after 18-h porcine pancreas preservation by ductal injection, pancreas preservation with MK solution, bottle purification, and islet purification using iodixanol with UW solution and iodixanol with MK solution[J]. J Clin Med, 2019, 8(10): 1561. DOI: 10.3390/jcm8101561.
    [79]
    NOGUCHI H, LEVY MF, KOBAYASHI N, et al. Pancreas preservation by the two-layer method: does it have a beneficial effect compared with simple preservation in University of Wisconsin solution?[J]. Cell Transplant, 2009, 18(5): 497-503. DOI: 10.1177/096368970901805-603.
    [80]
    QIN H, MATSUMOTO S, KLINTMALM GB, et al. A Meta-analysis for comparison of the two-layer and University of Wisconsin pancreas preservation methods in islet transplantation[J]. Cell Transplant, 2011, 20(7): 1127-1137. DOI: 10.3727/096368910X544942.
    [81]
    KUMAR R, CHUNG WY, RUNAU F, et al. Ex vivo normothermic porcine pancreas: a physiological model for preservation and transplant study[J]. Int J Surg, 2018, 54(Pt A): 206-215. DOI: 10.1016/j.ijsu.2018.04.057.
    [82]
    LEEMKUIL M, LIER G, ENGELSE MA, et al. Hypothermic oxygenated machine perfusion of the human donor pancreas[J]. Transplant Direct, 2018, 4(10): e388. DOI: 10.1097/TXD.0000000000000829.
    [83]
    PRUDHOMME T, KERVELLA D, OGBEMUDIA AE, et al. Successful pancreas allotransplantations after hypothermic machine perfusion in a novel diabetic porcine model: a controlled study[J]. Transpl Int, 2021, 34(2): 353-364. DOI: 10.1111/tri.13797.
    [84]
    DOPPENBERG JB, LEEMKUIL M, ENGELSE MA, et al. Hypothermic oxygenated machine perfusion of the human pancreas for clinical islet isolation: a prospective feasibility study[J]. Transpl Int, 2021, 34(8): 1397-1407. DOI: 10.1111/tri.13927.
    [85]
    WANG H, GOU W, STRANGE C, et al. Islet harvest in carbon monoxide-saturated medium for chronic pancreatitis patients undergoing islet autotransplantation[J]. Cell Transplant, 2019, 28(1 suppl): 25S-36S. DOI: 10.1177/0963689719890596.
    [86]
    中华医学会器官移植分会胰腺小肠移植学组. 中国临床胰岛制备技术专家共识[J]. 中华器官移植杂志, 2019, 40(9): 515-518. DOI: 10.3760/cma.j.issn.0254-1785.2019.09.002.

    Pancreas and Small Intestine Transplantation Group, Branch of Organ Transplantation of Chinese Medical Association. Expert consensus on clinical islet preparation technology in China[J]. Chin J Organ Transplant, 2019, 40(9): 515-518. DOI: 10.3760/cma.j.issn.0254-1785.2019.09.002.
    [87]
    IYER KR. Surgical management of short bowel syndrome[J]. JPEN J Parenter Enteral Nutr, 2014, 38 (1 Suppl): 53S-59S. DOI: 10.1177/0148607114529446.
    [88]
    KAWAI M, KITADE H, KOSHIBA T, et al. Intestinal ischemia reperfusion and lipopolysaccharide transform a tolerogenic signal into a sensitizing signal and trigger rejection[J]. Transplantation, 2009, 87(10): 1464-1467. DOI: 10.1097/TP.0b013e3181a3c387.
    [89]
    RAMISCH D, RUMBO C, ECHEVARRIA C, et al. Long-term outcomes of intestinal and multivisceral transplantation at a single center in Argentina[J]. Transplant Proc, 2016, 48(2): 457-462. DOI: 10.1016/j.transproceed.2015.12.066.
    [90]
    ABU-ELMAGD KM, COSTA G, BOND GJ, et al. Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges[J]. Ann Surg, 2009, 250(4): 567-581. DOI: 10.1097/SLA.0b013e3181b67725.
    [91]
    MANGUS RS, TECTOR AJ, FRIDELL JA, et al. Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in intestinal and multivisceral transplantation[J]. Transplantation, 2008, 86(2): 298-302. DOI: 10.1097/TP.0b013e31817ef074.
    [92]
    NICKKHOLGH A, CONTIN P, ABU-ELMAGD K, et al. Intestinal transplantation: review of operative techniques[J]. Clin Transplant, 2013, 27(Suppl 25): 56-65. DOI: 10.1111/ctr.12190.
    [93]
    OLTEAN M, JOSHI M, HERLENIUS G, et al. Improved intestinal preservation using an intraluminal macromolecular solution: evidence from a rat model[J]. Transplantation, 2010, 89(3): 285-290. DOI: 10.1097/TP.0b013e3181c9905a.
    [94]
    CANOVAI E, OLTEAN M, HERLENIUS G, et al. IGL-1 as a preservation solution in intestinal transplantation: a multicenter experience[J]. Transpl Int, 2020, 33(8): 963-965. DOI: 10.1111/tri.13625.
    [95]
    TESI RJ, JAFFE BM, MCBRIDE V, et al. Histopathologic changes in human small intestine during storage in Viaspan organ preservation solution[J]. Arch Pathol Lab Med, 1997, 121(7): 714-818.
    [96]
    ROSKOTT AM, NIEUWENHUIJS VB, DIJKSTRA G, et al. Small bowel preservation for intestinal transplantation: a review[J]. Transpl Int, 2011, 24(2): 107-131. DOI: 10.1111/j.1432-2277.2010.01187.x.
    [97]
    SØFTELAND JM, BAGGE J, PADMA AM, et al. Luminal polyethylene glycol solution delays the onset of preservation injury in the human intestine[J]. Am J Transplant, 2021, 21(6): 2220-2230. DOI: 10.1111/ajt.16418.
    [98]
    CHEN Z, KEBSCHULL L, FÖLL DA, et al. A novel histidine-tryptophan-ketoglutarate formulation ameliorates intestinal injury in a cold storage and ex vivo warm oxygenated reperfusion model in rats[J]. Biosci Rep, 2020, 40(5): BSR20191989. DOI: 10.1042/BSR20191989.
    [99]
    ZHU JZ, CASTILLO EG, SALEHI P, et al. A novel technique of hypothermic luminal perfusion for small bowel preservation[J]. Transplantation, 2003, 76(1): 71-76. DOI: 10.1097/01.TP.0000071381.17001.52.
    [100]
    MUÑOZ-ABRAHAM AS, PATRÓN-LOZANO R, NARAYAN RR, et al. Extracorporeal hypothermic perfusion device for intestinal graft preservation to decrease ischemic injury during transportation[J]. J Gastrointest Surg, 2016, 20(2): 313-321. DOI: 10.1007/s11605-015-2986-x.
    [101]
    GUO M, LU C, LI L, et al. Normothermic extracorporeal membrane oxygenation support: improving the function of intestinal grafts obtained from cardiac death donors[J]. Artif Organs, 2020, 44(10): 1098-1106. DOI: 10.1111/aor.13697.
    [102]
    HAMED MO, BARLOW AD, DOLEZALOVA N, et al. Ex vivo normothermic perfusion of isolated segmental porcine bowel: a novel functional model of the small intestine[J]. BJS Open, 2021, 5(2): zrab009. DOI: 10.1093/bjsopen/zrab009.
    [103]
    STEHLIK J, KOBASHIGAWA J, HUNT SA, et al. Honoring 50 years of clinical heart transplantation in circulation: in-depth state-of-the-art review[J]. Circulation, 2018, 137(1): 71-87. DOI: 10.1161/CIRCULATIONAHA.117.029753.
    [104]
    MINASIAN SM, GALAGUDZA MM, DMITRIEV YV, et al. Preservation of the donor heart: from basic science to clinical studies[J]. Interact Cardiovasc Thorac Surg, 2015, 20(4): 510-519. DOI: 10.1093/icvts/ivu432.
    [105]
    NIEDERBERGER P, FARINE E, RAILLARD M, et al. Heart transplantation with donation after circulatory death[J]. Circ Heart Fail, 2019, 12(4): e005517. DOI: 10.1161/CIRCHEARTFAILURE.118.005517.
    [106]
    MEHRA MR. Heart transplantation at 50[J]. Lancet, 2017, 390(10111): e43-e45. DOI: 10.1016/S0140-6736(17)33093-3.
    [107]
    MESSER S, PAGE A, COLAH S, et al. Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage[J]. J Heart Lung Transplant, 2018, 37(7): 865-869. DOI: 10.1016/j.healun.2018.03.017.
    [108]
    MACDONALD PS. Heart transplantation from DCD donors: from the bedside to the bench[J]. Transplantation, 2017, 101(8): 1753-1754. DOI: 10.1097/TP.0000000000001829.
    [109]
    BRANT SM, ROSENBAUM DH, COBERT ML, et al. Effects of antegrade and retrograde machine perfusion preservation on cardiac function after transplantation in canines[J]. Transplant Proc, 2014, 46(5): 1601-1605. DOI: 10.1016/j.transproceed.2014.03.006.
    [110]
    MEDRESSOVA A, FAIZOV L, KUANYSHBEK A, et al. Successful heart transplantation after 17 h ex vivo time using the Organ Care System-3 years follow-up[J]. J Card Surg, 2021, 36(7): 2592-2595. DOI: 10.1111/jocs.15519.
    [111]
    LEHMAN R, GERBER PA. End-stage nephropathy in type 1-diabetes mellitus-kidney transplantation alone or combined with islet or pancreas transplantation?[J]. Ther Umsch, 2011, 68(12): 699-706. DOI: 10.1024/0040-5930/a000233.
    [112]
    ARDEHALI A, ESMAILIAN F, DENG M, et al. Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED Ⅱ): a prospective, open-label, multicentre, randomised non-inferiority trial[J]. Lancet, 2015, 385(9987): 2577-2584. DOI: 10.1016/S0140-6736(15)60261-6.
    [113]
    SPONGA S, VENDRAMIN I, BORTOLOTTI U, et al. Ex vivo donor heart preservation in heart transplantation[J]. J Card Surg, 2021, 36(12): 4836. DOI: 10.1111/jocs.15978.
    [114]
    JIA JJ, LI JH, XIN L, et al. International Organ Protection Symposium: the fusion of engineering and medicine[J]. Hepatobiliary Pancreat Dis Int, 2019, 18(6): 601-602. DOI: 10.1016/j.hbpd.2019.07.012.
    [115]
    BONA M, WYSS RK, ARNOLD M, et al. Cardiac graft assessment in the era of machine perfusion: current and future biomarkers[J]. J Am Heart Assoc, 2021, 10(4): e018966. DOI: 10.1161/JAHA.120.018966.
    [116]
    WHITE CW, AMBROSE E, MÜLLER A, et al. Assessment of donor heart viability during ex vivo heart perfusion[J]. Can J Physiol Pharmacol, 2015, 93(10): 893-901. DOI: 10.1139/cjpp-2014-0474.
    [117]
    CARTER KT, LIRETTE ST, BARAN DA, et al. The effect of cardiac preservation solutions on heart transplant survival[J]. J Surg Res, 2019, 242: 157-165. DOI: 10.1016/j.jss.2019.04.041.
    [118]
    RIBEIRO R, GHASHGHAI A, YU F, et al, Comparison between Steen and Somah solutions as primary perfusate components for ex vivo heart perfusion[J]. Canadian J Cardiol, 2017, 33(10): S69. DOI: 10.1016/j.cjca.2017.07.142.
    [119]
    HU CX, CHEN WH, HE JX, et al. Lung transplantation in China between 2015 and 2018[J]. Chin Med J (Engl), 2019, 132(23): 2783-2789. DOI: 10.1097/CM9.0000000000000543.
    [120]
    WHITFORD H, KURE CE, HENRIKSEN A, et al. A donor PaO2/FiO2 < 300 mmHg does not determine graft function or survival after lung transplantation[J]. J Heart Lung Transplant, 2020, 39(1): 53-61. DOI: 10.1016/j.healun.2019.08.021.
    [121]
    FARR M, TRUBY LK, LINDOWER J, et al. Potential for donation after circulatory death heart transplantation in the United States: retrospective analysis of a limited UNOS dataset[J]. Am J Transplant, 2020, 20(2): 525-529. DOI: 10.1111/ajt.15597.
    [122]
    WOOLLEY AE, SINGH SK, GOLDBERG HJ, et al. Heart and lung transplants from HCV-infected donors to uninfected recipients[J]. N Engl J Med, 2019, 380(17): 1606-1617. DOI: 10.1056/NEJMoa1812406.
    [123]
    BUCHKO MT, BOROUMAND N, CHENG JC, et al. Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs[J]. Nat Commun, 2020, 11(1): 5765. DOI: 10.1038/s41467-020-19581-4.
    [124]
    COPELAND H, HAYANGA JWA, NEYRINCK A, et al. Donor heart and lung procurement: a consensus statement[J]. J Heart Lung Transplant, 2020, 39(6): 501-517. DOI: 10.1016/j.healun.2020.03.020.
    [125]
    LEVVEY B, KESHAVJEE S, CYPEL M, et al. Influence of lung donor agonal and warm ischemic times on early mortality: analyses from the ISHLT DCD Lung Transplant Registry[J]. J Heart Lung Transplant, 2019, 38(1): 26-34. DOI: 10.1016/j.healun.2018.08.006.
    [126]
    MUNSHI L, KESHAVJEE S, CYPEL M. Donor management and lung preservation for lung transplantation[J]. Lancet Respir Med, 2013, 1(4): 318-328. DOI: 10.1016/S2213-2600(12)70064-4.
    [127]
    王振兴, 陈静瑜, 郑明峰, 等. 肺移植供肺获取100例: 冷缺血时间≥ 6h及肺减容对预后的影响[J]. 中国组织工程研究, 2012, 16(5): 835-838. DOI: 10.3969/j.issn.1673-8225.2012.05.018.

    WANG ZX, CHEN JY, ZHENG MF, et al. 100 cases of lung harvesting for lung transplantation: effect of cold ischemia time ≥ 6 hours and lung volume reduction on prognosis[J]. Chin J Tissue Eng Res, 2012, 16(5): 835-838. DOI: 10.3969/j.issn.1673-8225.2012.05.018.
    [128]
    LEIVA-JUÁREZ MM, URSO A, ARANGO TOMÁS E, et al. Extended post-ex vivo lung perfusion cold preservation predicts primary graft dysfunction and mortality: results from a multicentric study[J]. J Heart Lung Transplant, 2020, 39(9): 954-961. DOI: 10.1016/j.healun.2020.05.002.
    [129]
    LUND LH, KHUSH KK, CHERIKH WS, et al. The Registry of the International Society for Heart and Lung Transplantation: thirty-fourth adult heart transplantation report-2017; focus theme: allograft ischemic time[J]. J Heart Lung Transplant, 2017, 36(10): 1037-1046. DOI: 10.1016/j.healun.2017.07.019.
    [130]
    MARASCO SF, BAILEY M, MCGLADE D, et al. Effect of donor preservation solution and survival in lung transplantation[J]. J Heart Lung Transplant, 2011, 30(4): 414-419. DOI: 10.1016/j.healun.2010.10.002.
    [131]
    TIAN D, WANG Y, SHⅡYA H, et al. Outcomes of marginal donors for lung transplantation after ex vivo lung perfusion: a systematic review and Meta-analysis[J]. J Thorac Cardiovasc Surg, 2020, 159(2): 720-730. DOI: 10.1016/j.jtcvs.2019.07.087.
    [132]
    LOOR G, WARNECKE G, VILLAVICENCIO MA, et al. Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (expand): a single-arm, pivotal trial[J]. Lancet Respir Med, 2019, 7(11): 975-984. DOI: 10.1016/S2213-2600(19)30200-0.
    [133]
    OZER K. Advances in limb preservation: from replantation to transplantation[J]. J Hand Surg Am, 2020, 45(7): 626-637. DOI: 10.1016/j.jhsa.2020.04.006.
    [134]
    REECE E, ACKAH R. Hand transplantation: the benefits, risks, outcomes, and future[J]. Tex Heart Inst J, 2019, 46(1): 63-64. DOI: 10.14503/THIJ-18-6739.
    [135]
    WILKS DJ, CLARK B, KAY SPJ. The histocompatibility and immunogenetics of hand transplantation[J]. Int J Immunogenet, 2020, 47(1): 24-27. DOI: 10.1111/iji.12469.
    [136]
    SCHNEEBERGER S, PETRUZZO P, MORELON E, et al. 20-year follow-up of two cases of bilateral hand transplantation[J]. N Engl J Med, 2020, 383(18): 1791-1792. DOI: 10.1056/NEJMc2017711.
    [137]
    CARLSEN BT, AL-MUFARREJ F, MORAN SL. Surgical anatomy of hand allotransplantation[J]. Clin Anat, 2013, 26(5): 578-583. DOI: 10.1002/ca.22229.
    [138]
    裴国献. 异体肢体移植[M]. 北京: 人民卫生出版社, 2009.
    [139]
    TATUM R, O'MALLEY TJ, BODZIN AS, et al. Machine perfusion of donor organs for transplantation[J]. Artif Organs, 2021, 45(7): 682-695. DOI: 10.1111/aor.13894.
    [140]
    AMIN KR, WONG JKF, FILDES JE. Strategies to reduce ischemia reperfusion injury in vascularized composite allotransplantation of the limb[J]. J Hand Surg Am, 2017, 42(12): 1019-1024. DOI: 10.1016/j.jhsa.2017.09.013.
    [141]
    GOK E, KUBIAK CA, GUY E, et al. Effect of static cold storage on skeletal muscle after vascularized composite tissue allotransplantation[J]. J Reconstr Microsurg, 2020, 36(1): 9-15. DOI: 10.1055/s-0039-1693455.
    [142]
    HAUG V, KOLLAR B, TASIGIORGOS S, et al. Hypothermic ex situ perfusion of human limbs with acellular solution for 24 hours[J]. Transplantation, 2020, 104(9): e260-e270. DOI: 10.1097/TP.0000000000003221.
    [143]
    SAID SA, ORDEÑANA CX, REZAEI M, et al. Ex-vivo normothermic limb perfusion with a hemoglobin-based oxygen carrier perfusate[J]. Mil Med, 2020, 185 (Suppl 1): 110-120. DOI: 10.1093/milmed/usz314.
    [144]
    KREZDORN N, MACLEOD F, TASIGIORGOS S, et al. Twenty-four-hour ex vivo perfusion with acellular solution enables successful replantation of porcine forelimbs[J]. Plast Reconstr Surg, 2019, 144(4): 608e-618e. DOI: 10.1097/PRS.0000000000006084.
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